Stress, Cancer, and the Mind

  • Hans Selye
Part of the Sloan-Kettering Institute Cancer Series book series (SKICS)


Research on stress has progressed so rapidly in recent years that even our own Documentation Center has by now compiled an awe-inspiring 150,000 entries on stress and stress-related topics. The literature explosion has been even more considerable in connection with cancer research and psychosomatic medicine; this made it seem opportune in 1976 to present an overview of the entire field as it relates to virtually every facet of life in health and disease. (1) However, new developments in stress research continue to occur almost every day, and this creates a pressing need for annual overviews of the latest findings of our colleagues in this field. (2)


Psychosomatic Medicine Polyoma Virus Stress Research Murine Sarcoma Virus General Adaptation Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Selye, H. Stress in Health and Disease. Reading, Mass.: Butterworth, 1976.Google Scholar
  2. 2.
    Selye, H. Selye’s Guide to Stress Research. New York: Van Nostrand Reinhold, in press.Google Scholar
  3. 3.
    Selye, H. A syndrome produced by diverse nocuous agents. Nature (London) 138:32, 1936.CrossRefGoogle Scholar
  4. 4.
    Selye, H. Stress as a cause and consequence of peptic ulcers. Nutley, N.J.: Roche Psychiatric Service Institute, in press.Google Scholar
  5. 5.
    Selye, H. Stress and cardiovascular disease. Cardiovas. Med., in press.Google Scholar
  6. 6.
    Selye, H. Psychosocial implications of the stress concept. In: T. Manschreck (Ed.), The Massachusetts General Hospital Series on Psychiatric Medicine. New York: Elsevier North-Holland, in press.Google Scholar
  7. 7.
    Selye, H. The Stress of My Life. Toronto: McClelland & Stewart, 1977. Revised updated edition, New York: Van Nostrand Reinhold, in press.Google Scholar
  8. 8.
    Selye, H. Stress Without Distress. New York: J. B. Lippincott, 1974.Google Scholar
  9. 9.
    Selye, H. The Stress of Life. 1st edition, New York: McGraw-Hill, 1956. 2nd edition, New York: McGraw-Hill, 1976.Google Scholar
  10. 10.
    Guy, R. An Essay on Scirrhus Tumors and Cancers. London: J. & A. Churchill, 1759.Google Scholar
  11. 11.
    Parker, W. Cancer. A Study of 397 Cases of Cancer of the Female Breast. New York: G. P. Putnam & Sons, 1885.Google Scholar
  12. 12.
    Cutter, E. Diet on cancer. Albany Med. J. 8:218–251, July-August, 1887.Google Scholar
  13. 13.
    Amussat, J. Z. Quelques Réflexions sur la Curabilité du Cancer. Paris: E. Thunot, 1854.Google Scholar
  14. 14.
    Paget, J. Surgical Pathology. London: Longmans Green, 1870.Google Scholar
  15. 15.
    Kowal, S. J. Emotions as a cause of cancer. Psychoanal. Rev. 42:217–227, 1955.PubMedGoogle Scholar
  16. 16.
    McEuen, C. S., and Selye, H. Histologic changes in the adrenals of tumorbearing rats. Am. J. Med. Sci. 189:423–424, 1935.CrossRefGoogle Scholar
  17. 17.
    Hilf, R., Burnett, F. F., and Borman, A. The effect of Sarcoma 180 and other stressing agents upon adrenal and plasma corticosterone in mice. Cancer Res. 20:1389–1393, 1960.PubMedGoogle Scholar
  18. 18.
    Hilf, R., Breuer, C, and Borman, A. The effect of Sarcoma 180 and other stressing agents upon adrenal adenine nucleotide-metabolizing enzymes. Cancer Res. 21:1439–1444, 1961.PubMedGoogle Scholar
  19. 19.
    Moore, D. C., Holton, C. P., and Marten, G. W. Psychologic problems in the management of adolescents with malignancy. Experiences with 182 patients. Clin. Pediatr. 8:464–473, 1969.CrossRefGoogle Scholar
  20. 20.
    Ertl, N. “Systemic effects” during the growth of malignant experimental tumors. Oncologia (Basel) 27:415–429, 1973.CrossRefGoogle Scholar
  21. 21.
    Lemonde, P. Influence of fighting on leukemia in mice. Proc. Soc. Exp. Biol. Med. 102:292–295, 1959.PubMedGoogle Scholar
  22. 22.
    Slawikowski, G. J. M. Tumor development in adrenalectomized rats given inoculations of aged tumor cells after surgical stress. Cancer Res. 20:316–320, 1960.PubMedGoogle Scholar
  23. 23.
    Griffiths, J. D., and Hoppe, E. Effect of metabolic “stress” on development of tumor following inoculation of Walker carcinosarcoma cells. Proc. Soc. Exp. Biol. Med. 104:467–469, 1960.PubMedGoogle Scholar
  24. 24.
    Gottfried, B., and Molomut, N. The influence of surgical trauma on the growth of tumor. An experimental evaluation. J. Int. Coll. Swrg. 36:Section 1, 596–602, 1961.Google Scholar
  25. 25.
    Gottfried, B., and Molomut, N. Effects of surgical trauma and other environmental stressors on tumor growth and wound healing. Acta Unio. Int. Cancr. 20:1617–1620, 1964.Google Scholar
  26. 26.
    Pradhan, S. N., and Ray, P. Effects of stress on growth of transplanted and 7,12-dimethylbenz[α]anthracene-induced tumors and their modification by psychotropic drugs. J. Natl. Cancer Inst. 53:1241–1245, 1974.PubMedGoogle Scholar
  27. 27.
    Cole, W. H. The mechanisms of spread of cancer. Surg. Gynec. Obstet. 137:853–871, 1973.PubMedGoogle Scholar
  28. 28.
    Bass, A. D., and Feigelson, M. Response of normal and malignant lymphoid tissue to non-specific tissue damage. Proc. Soc. Exp. Biol. Med 69:339–341, 1948.PubMedGoogle Scholar
  29. 29.
    Stern, J. A., Winokur, G., Graham, D. T, and Lefton, R. Effect of enforced activity stress on the development of experimental papillomas in mice. J. Natl. Cancer Inst 23:1013–1018, 1959.PubMedGoogle Scholar
  30. 30.
    Selye, H. An experimental model illustrating the pathogenesis of the diseases of adaptation. J. Clin. Endocrinol. Metab. 14:997–1005, 1954.PubMedCrossRefGoogle Scholar
  31. 31.
    Arasa, F. La problemática del cáncer vista por un médico humanista. Folia Clin. Int (Barcelona) 24:547–557, 1974.Google Scholar
  32. 32.
    Solomon, G. F. Emotions, stress, the central nervous system, and immunity. Ann. N.Y. Acad. Sci. 164:335–343, 1969.PubMedCrossRefGoogle Scholar
  33. 33.
    Amkraut, A. A., Solomon, G. F., Kasper, P., and Purdue, A. Stress and hormonal intervention in the graft-versus-host response. Adv. Exp. Med. Biol. 29:667–674, 1973.PubMedGoogle Scholar
  34. 34.
    Seifter, E., Rettura, G., Zisblatt, M., Levenson, S. M., Levine, N., Davidson, A., and Seifter, J. Enhancement of tumor development in physically-stressed mice inoculated with an oncogenic virus. Experientia 29:1379–1382, 1973.PubMedCrossRefGoogle Scholar
  35. 35.
    Spackman, D., and Riley, V. Increased corticosterone, a factor in LDH-virus induced alterations of immunological responses in mice. Proc. Amer. Assoc. Cancer Res. 15:143, 1974.Google Scholar
  36. 36.
    Howard, R. J., and Simmons, R. L. Acquired immunologic deficiencies after trauma and surgical procedures. Surg. Gynec. Obstet. 139:771–782, 1974.PubMedGoogle Scholar
  37. 37.
    Rasmussen, A. F., Hildemann, W. H., and Sellers, M. Malignancy of polyoma virus infection in mice in relation to stress. J. Natl. Cancer Inst 30:101–112, 1963.PubMedGoogle Scholar
  38. 38.
    Ray, P., and Pradhan, S. N. Brief communication: Growth of transplanted and induced tumors in rats under a schedule of punished behavior. J. Natl. Cancer Inst 52:575–577, 1974.PubMedGoogle Scholar
  39. 39.
    Achterberg, J., and Lawlis, G. F. Imagery of Cancer. Champaign, DL: Institute for Personality & Ability Testing, 1978.Google Scholar
  40. 40.
    Weinstock, C. Recent progress in cancer psychobiology and psychiatry. J. Amer. Soc. Psychosom. Dent. Med 24:4–14, 1977.Google Scholar
  41. 41.
    Pendergrass, E. Presidential address to American Cancer Society Meeting, 1959.Google Scholar
  42. 42.
    Reichel, S. Severe Sustained Emotional Stress and Cancer. S. M. Reichel, 1977.Google Scholar
  43. 43.
    Simonton, O. C., and Simonton, S. S. Belief systems and management of the emotional aspects of malignancy. J. Trans. Psychol 7:29–47, 1975.Google Scholar
  44. 44.
    Whitlock, F. A. Suicide, cancer and depression. Brit. J. Psychiat.132:269–274, 1978.Google Scholar
  45. 45.
    Fredrick, J. F. Grief as a disease process. Omega (Westport, Conn.) 7:297–305, 1977.Google Scholar
  46. 46.
    Watson, C. G., and Schuld, D. Psychosomatic factors in the etiology of neoplasms. J. Cons. Clin. Psychol. 45:455–461, 1977.CrossRefGoogle Scholar
  47. 47.
    Rothenberg, A. Psychological problems in terminal cancer management. Cancer (Philadelphia) 14:1063–1073, 1961.CrossRefGoogle Scholar
  48. 48.
    McCollum, P. S. Adjustment to cancer: A psychosocial and rehabilitative perspective. Rehabil. Council Bull. 21:216–223, 1978.Google Scholar
  49. 49.
    Achterberg, Matthews, S., and Simonton, O. C. Psychology of the exceptional cancer patient: A description of patients who outlive predicted life expectancies. Psychother. Theory Res. Pract. June 21:1–21, 1976.Google Scholar

Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • Hans Selye
    • 1
  1. 1.International Institute of StressUniversity of MontrealMontrealCanada

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