Diabetes Mellitus

  • Stefan S. Fajans
  • John C. FloydJr.


In recent years, the close association of genes controlling the immune response with a variety of antigens of the major histocompatibility system (HLA) has been well established. Such an association was found mainly in those diseases in the pathogenesis of which immunological mechanisms are active. It seems likely that genes at loci closely linked to HLA loci are involved in susceptibility to diabetes. Whether these HLA-linked diabetic genes code for viral receptors, are associated with an immune response gene to pancreatic or viral antigens, or are linked to diabetes in some other ways is not known (Notkins, 1977).


Beta Cell Diabetic Ketoacidosis Oral Hypoglycemic Agent Gastric Inhibitory Polypeptide Islet Cell Antibody 
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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • Stefan S. Fajans
    • 1
  • John C. FloydJr.
    • 1
  1. 1.Division of Endocrinology and Metabolism, Metabolism Research Unit, and Michigan Diabetes Research and Training CenterThe University of MichiganAnn ArborUSA

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