Abstract
The most common method employed in altering the nutritional status of neonatal rats is to vary the number of pups nursing from a single mother. The normal rat litter consists of from 8 to 12 pups; a nursing group of 10 animals has arbitrarily been considered normal. Malnutrition is imposed by increasing the size of the nursing group to 18 animals and overnutrition by decreasing the size to 3 animals. But in addition to altering the nutrition, this changes the amount of maternal stimulation available to each pup. More recently, other methods of inducing undernutrition have been employed. Protein restriction in the lactating mother reduces the quantity of milk produced without altering its composition. Allowing the animals to nurse for only a single 8-hr period per day also reduces the quantity of milk consumed. In a combination of these approaches, protein-restricted mothers have been given an increased number of animals to nurse. All these methods produce a total caloric restriction as well as a restriction in individual nutrients, the most important of which is probably protein. So far, all the methods have had comparable effects on brain growth, and we will therefore examine them together.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bieber, M. A., Pulito, A. R., Brasel, J. A., and Heird, W. C., 1976, Effect of total parenteral nutrition on serum and tissue essential fatty acid status, Fed. Proc. Fed. Am. Soc. Exp. Biol. 35: 262 (abstract).
Bretscher, M. S., 1973, Membrane structure: Some general principles, Science 181: 622–629.
Brunngraber, E. G., Witting, L. A., Haberland, C., and Brown, B., 1972, Glycoproteins in Tay-Sachs disease: Isolation and carbohydrate composition of glycopeptides. Brain Res. 38: 151–162.
Burton, R. M., Howard, R. E., Baer, S., and Balfour, Y. M., 1964, Gangliosides and acetylcholine of the central nervous system, Biochim. Biophys. Acta 84: 441–447.
Chase, H. P., Dorsey, J., and McKhann, G. M., 1967, The effect of malnutrition on the synthesis of a myelin lipid. Pediatrics 40: 551–559.
Culley, W. J., and Lineberger, R. O., 1968, Effect of undernutrition on the size and composition of the rat brain, J. Nutr. 96: 375–381.
Davison, A. N., and Dobbing, J., 1966, Myelination as a vulnerable period in brain development, Br. Med. Bull. 22: 40–44.
Davison, A. N., and Dobbing, J., 1968, The developing brain, in: Applied Neuro- chemistry ( A. N. Davison and J. Dobbing, eds.), p. 253, F. A. Davis, Philadelphia.
Dekirmenjian, H., and Brunngraber, E. G., 1969, Distribution of protein-bound A-acetylneuraminic acid in subcellular particulate fractions prepared from rat whole brain, Biochim. Biophys. Acta 177: 1–10.
Dekirmenjian, H., Brunngraber, E. G., Lemkey-Johnston, N., and Larramendi, L. M. H., 1969, Distribution of gangliosides, glycoprotein-NANA and acetylcholinesterase in axonal and synaptosomal fractions of cat cerebellum, Exp. Brain Res. 8: 97–104.
Dette, G. A., and Weseman, W., 1978, On the significance of sialic acid in high affinity 5–hydroxytryptamine uptake by synaptosomes, Hoppe-Seyler’s Z. Physiol. Chem. 359: 399–406.
DiBenedetta, C., and Cioffi, L. A., 1972, Early malnutrition, brain glycoproteins and behavior in rats, Bibl. Nutr. Dieta 17: 69–82.
Dickerson, J. W. T., and Jarvis, J., 1970, The effect of undernutrition and subsequent rehabilitation on the growth and chemical composition of the cerebellum, brain stem and forebrain of the rat, Proc. Nutr. Soc. 29: 4A.
Dickerson, J. W. T., Dobbing, J., and McCance, R. A., 1966–1967, The effect of undernutrition on the postnatal development of the brain and cord in pigs, Proc. R. Soc. London Ser. B 166: 396–407.
Dobbing, J., and Sands, J., 1973, Quantitative growth and development of human brain, Arch. Dis. Child. 48: 757–767.
Dyson, S. E., and Jones, D. G., 1976a, The morphological characterization of developing synaptic junctions, Cell Tissue Res. 167: 363–371.
Dyson, S. E., and Jones, D. G., 1976b, Some effects of undernutrition on synaptic development—A quantitative ultrastructural study. Brain Res. 114: 365–378.
Eayrs, J. T., and Goodhead, B., 1959, Postnatal development of the cerebral cortex in the rat, J. Anat. 93: 385–402.
Eayrs, J. T., and Horn G., 1955, The development of cerebral cortex in hypothyroid and starved rats, Anat. Rec. 121: 53–61.
Fish, I., and Winick, M., 1969, Effect of malnutrition on regional growth of the developing rat brain, Exp. Neurol. 25: 534–540.
Galli, G., 1973, Dietary lipids and brain development, in: Dietary Lipids in Postnatal Development ( G. Galli, G. Jacini, and A. Pecile, eds.), pp. 191–202, Raven Press, New York.
Hamberger, A., and Svennerholm, L., 1971, Composition of gangliosides and phospholipids of neuronal and glial cell enriched fractions, J. Neurochem. 18: 1821–1829.
Hess, H. H., Bass, N. H., Thalheimer, C., and Devarakonda, R., 1976, Gangliosides and the architecture of human frontal and rat somatosensory isocortex, J. Neurochem. 26: 1115–1121.
Holm, M., and Svennerholm, L., 1972, Biosynthesis and biodégradation of rat brain gangliosides studied in vivo, J. Neurochem. 19: 609–622.
Im, H. S., Barnes, R. H., Levitsky, D., Krook, L., and Pond, W. G., 1972, Postnatal malnutrition and regional cholinesterase activities in brain of pigs. Fed. Proc. Fed. Am. Soc. Exp. Biol. 31: 697 (abstract).
Jackson, G. M., and Steward, G. A., 1920, The effects of inanition in the young upon the ultimate size of the body and of the various organs in the albino rat, J. Exp. ZooL 30: 97–128.
James, E., and Eotherby, K., 1963, Distribution in brain of lipid bound sialic acid and factors affecting its concentration, J. Neurochem. 10: 587–592.
Lapetina, E. G., Soto, E. F., and DeRobertis, E., 1968, Lipids and proteolipids in isolated subcellular membranes of rat brain cortex, J. Neurochem. 15: 437–445.
Ledeen, R. W., 1978, Ganglioside structure and distribution: Are they localized at the nerve ending?,J. Supramol. Struct. 8: 1–17.
Lehninger, A. L., 1968, The neuronal membrane, Proc. Natl Acad. Sci. U.S.A. 60: 1069–1080.
Mcllwain, H., 1961, Characterization of naturally occurring materials which restore excitability to isolated cerebral tissues, Biochem.J. 78: 24–32.
Merat, A., and Dickerson, J. W. T., 1973, The effect of development on the gangliosides of rat and pig brain, J. Neurochem. 20: 873–880.
Morgan, B. L. G., and Naismith, D. J., 1979, The effect of early post-natal undernutrition on the growth and development of the rat brain, Br. J Nutr. (in press).
Morgan, B. L. G., and Winick, M., 1979a, Effects of environmental stimulation on brain ganglioside A’-acetylneuraminic acid content in relation to behavior (submitted for publication).
Morgan, B. L. G., and Winick, M., 1979b, Effects of administration of A-acetyl- neuraminic acid (NANA) on brain ganglioside NANA in relation to behavior (submitted for publication).
Norton, W. T., and Poduslo, S. E., 1971, Neuronal perikarya and astroglia of rat brain: Chemical composition during myelination,J. Lipid Res. 12: 84–90.
Piatt, B. S., 1962, Proteins in nutrition, Proc. R. Soc. London Ser. B 156: 337–344.
Pritchard, E. T., and Cantin, P. L., 1962, Gangliosides in maturing rat brain, Nature (London) 193: 580–581.
Rahmann, H., Rosner, H., and Breer, H., 1976, A functional model of sialoglycomacromolecules in synaptic transmission and memory formation, J. Theor. Biol. 57: 231–237.
Rajalakshmi, R., and Nakhasi, H. L., 1976, Effects of neonatal undernutrition on the lipid composition of the spinal cord in rats, Exp. Neurol. 51: 330–336.
Rees, R. P., 1978, The morphology of interneuronal synaptogenesis: A review. Fed. Proc. Fed. Am. Soc. Exp. Biol. 37: 2000–2009.
Rosso, P., Hormazabal, J., and Winick, M., 1970, Changes in brain weight, cholesterol, phospholipid and DNA content in marasmic children, Am. J. Clin. Nutr. 23: 1275–1279.
Roukema, P. A., VanDenEijnden, D. H., Heijlman, J., and Van DerBerg, G., 1970, Sialoglycoproteins, gangliosides and related enzymes in developing rat brain, FEBS Lett. 9: 267–270.
Salas, M., Diaz, S., and Nieto, A., 1974, Effects of neonatal food deprivation on cortical spines and dendritic development of the rat, Brain Res. 73: 139–144.
Schengrund, C. L., and Nelson, J. T., 1975, Influence of cation concentration on the sialidase activity of neuronal synaptic membranes, Biochem. Biophys. Res. Commun. 63: 217–223.
Schengrund, C. L., and Rosenberg, A., 1970, Intracellular location and properties of bovine brain sialidase,J. Biol. Chem. 245: 6196–6200.
Shoemaker, W. J., and Wurtman, R. J., 1971, Perinatal undernutrition: Accumulation of catecholamines in rat brain, Science 171: 1017–1019.
Sima, A., 1974, Studies on fibre size in developing sciatic nerve and spinal roots in normal, undernourished, and rehabilitated rats. Acta Physiol. Scand. ( Suppl. ) 406: 1–55.
Suzuki, K., 1965, The pattern of mammalian brain gangliosides. II. Evaluation of the extraction procedures, postmortem changes and the effect of formalin preservation,J. Neurochem. 12: 629–638.
Suzuki, K., 1967, Formation and turnover of the major brain gangliosides during development, J. Neurochem. 14: 917–925.
Svennerholm, L., 1970, Deamination of nucleotides and the role of their deamino forms in ammonia formation from amino acids, in: Handbook of Neurochemis- try. Vol. 3 ( A. Lajtha, ed.), pp. 425–452, Plenum Press, New York.
Ulus, I. H., and Wurtman, R. J., 1976, Choline administration: Activation of tyrosine hydroxylase in dopaminergic neurons of rat brain. Science 194: 1060–1061.
Widdowson, E. M., and McCance, R. A., 1960, Some effects of accelerating growth. I. General somatic development, Proc. R. Soc. London Ser. B 152: 188–206.
Winick, M., 1970, Cellular growth in intrauterine malnutrition, Pediatr. Clin. North Am. 17: 69–78.
Winick, M., 1976, Nutrition and cellular growth of the brain, in: Malnillrition and Brain Development, p. 67, Oxford University Press, New York.
Winick, M., and Noble, A., 1966, Cellular response in rats during malnutrition at various ages, J. Nutr. 89: 300–306.
Winick, M., and Rosso, P., 1969, The effect of severe early malnutrition on cellular growth of human brain, Pediatr. Res. 3: 181–184.
Winick, M., Fish, I., and Rosso, P., 1968, Cellular recovery in rat tissues after a brief period of neonatal malnutrition, J. Nutr. 95: 623–626.
Winick, M., Rosso, P., and Waterlow, J., 1970, Cellular growth of cerebrum, cerebellum, and brain stem in normal and marasmic children, Exp. Neurol. 26: 393–400.
Wurtman, R. J., and Fernstrom, J. D., 1976, Control of brain neurotransmitter synthesis by precursor availability and nutritional state, Biochem. Pharmacol. 25: 1691–1696.
Yu, M. C., and Yu, W. A., 1977, Ultrastructural changes in the developing rat cerebellum in chronic undernutrition, Neuropathol. Appl. Neurohiol. 3: 391–401.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1979 Plenum Publishing Corporation
About this chapter
Cite this chapter
Winick, M., Morgan, B.L.G. (1979). Nutrition and Cellular Growth of the Brain. In: Freinkel, N. (eds) Contemporary Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3447-7_4
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3447-7_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3449-1
Online ISBN: 978-1-4684-3447-7
eBook Packages: Springer Book Archive