Disorders of Lipid and Lipoprotein Metabolism

  • DeWitt S. Goodman


This chapter will review the major advances that occurred during 1977 and early 1978 with regard to our knowledge of the major plasma lipids and lipoproteins, and about clinical abnormalities in lipid transport, with particular emphasis on the hyperlipidemias. The chapter will build on, and in part briefly summarize, the information and ideas reviewed during the past two years (Goodman, 1976, 1978). For excellent and in-depth reviews of familial disorders characterized by evidence of abnormal lipid metabolism, the reader is referred to the recent fourth edition of the textbook by Stanbury et al (1978).


Cholesteryl Ester High Density Lipoprotein Familial Hypercholesterolemia Lipoprotein Metabolism Familial Hypercholesterolemia 
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  1. Albers, J. J., Adolphson, J. L., and Hazzard, W. R., 1977a, Radioimmunoassay of human plasma Lp(a) lipoprotein, J. Lipid Res. 18: 331–338.PubMedGoogle Scholar
  2. Albers, J. J., Warnick, G. R., and Hazzard, W. R., 1977b, Type III hyperlipoproteinemia: A comparative study of current diagnostic techniques, Clin. Chim. Acta 75: 193–204.Google Scholar
  3. Ames, R. P., and Hill, P., 1976, Elevation of serum lipid levels during diuretic therapy of hypertension, Am. J. Med. 61: 748–757.CrossRefGoogle Scholar
  4. Andersen, J. M., and Dietschy, J. M., 1977, Regulation of sterol synthesis in 15 tissues of rat. 11. Role of rat and human high and low density plasma lipoproteins and of rat chylomicron remnants,J. Biol. Chem. 252: 3652–3659.Google Scholar
  5. Anderson, D. W., Nichols, A. V., Forte, T. M., and Lindgren, F. T., 1977, Particle distribution of human serum high density lipoproteins, Biochim. Biophys. Acta 493: 55–68.Google Scholar
  6. Anderson, R. G. W., Brown, M. S., and Goldstein, J. L., 1977, Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts, Cell 10: 351–364.PubMedCrossRefGoogle Scholar
  7. Applebaum, D. M., Goldberg, A. P., Pykalisto, O. J., Brunzell, J. D., and Hazzard, W. R., 1977, Effect of estrogen on post-heparin lipolytic activity: Selective decline in hepatic triglyceride lipase,J. Clin. Invest. 59: 601–608.CrossRefGoogle Scholar
  8. Armstrong, M. L., Warner, E. D., and Connor, W. E., 1970, Regression of coronary atheromatosis in rhesus monkeys, Circ. Res. 27: 59–67.PubMedGoogle Scholar
  9. Assmann, G., Smootz, E., Adler, K., Gapurso, A., and Oette, K., 1977a, The lipoprotein abnormality in Tangier disease: Quantitation of A apoproteins,J. Clin. Invest. 59: 565–575.CrossRefGoogle Scholar
  10. Assmann, G., Simantke, O., Schaefer, H.-E., and Smootz, E., 1977b, Characterization of high density lipoproteins in patients heterozygous for Tangier disease, J. Clin. Invest. 60: 1025–1035.CrossRefGoogle Scholar
  11. Bagdade, J. D., and Albers, J. J., 1977, Plasma high-density lipoprotein concentrations in chronic-hemodialysis and renal-transplant patients, N. Engl. J. Med. 296: 1436–1439.Google Scholar
  12. Barndt, R., Jr., Blankenhorn, D. H., Crawford, D. W., and Brooks, S. H., 1977, Regression and progression of early femoral atherosclerosis in treated hyper- lipoproteinemic patients, Ann. Intern. Med. 86: 139–146.Google Scholar
  13. Basu, S. K., Anderson, R. G. W., Goldstein, J. L., and Brown, M. S., 1977, Metabolism of cationized lipoproteins by human fibroblasts: Biochemical and morphologic correlations, J. Cell Biol. 74: 119–135.Google Scholar
  14. Berman, M., Hall, M., Ill, Levy, R. I., Eisenberg, S., Bilheimer, D. W., Phair, R. D., and Goebel, R. H., 1978, Metabolism of apoB and apoC hpoproteins in man: Kinetic studies in normal and hyperlipoproteinemic subjects, J. Lipid Res. 19: 38–56.Google Scholar
  15. Bilheimer, D. W., Ho, Y. K., Brown, M. S., Anderson, R. G. W., and Goldstein, J. L., 1978, Genetics of the low density lipoprotein receptor: Diminished receptor activity in lymphocytes from heterozygotes with familial hypercholesterolemia,Clin. Invest. 61: 678–696.Google Scholar
  16. Blum, C. B., Lew, R. 1., Eisenberg, S., Hall, M., Ill, Goebel, R. H., and Berman, M., 1977, High density lipoprotein metabolism in man, J. Clin. Invest. 60: 795–807.Google Scholar
  17. Brown, M. S., Anderson, R. G. W., and Goldstein, J. L., 1977, Mutations affecting the binding, internalization, and lysosomal hydrolysis of low density lipoprotein in cultured human fibroblasts, lymphocytes, and aortic smooth muscle cells,J. Supramol. Struct. 6: 85–94.CrossRefGoogle Scholar
  18. Buchwald, H., Moore, R. B., and Varco, R. L., 1977, Maximum lipid reduction by partial ileal bypass: A test of the lipid-atherosclerosis hypothesis, Lipids 12: 53–58.Google Scholar
  19. Castelli, W. P., Cooper, G. R., Doyle, J. T., Garcia-Palmieri, M., Gordon, T., Hames, G., Hulley, S. B., Kagan, A., Kuchmak, M., McGee, D., and Vicic, W. J., 1977a, Distribution of triglyceride and total, LDL and HDL cholesterol in several populations: A cooperative lipoprotein phenotyping study, J. Chron. Dis. 30: 147–169.Google Scholar
  20. Castelli, W. P., Doyle, J. T., Gordon, T., Hames, C. G., Hjortland, M. C., Hulley, S. B., Kagan, A., and Zukel, W. J., 1977b, HDL cholesterol and other lipids in coronary heart disease: The cooperative lipoprotein phenotyping study. Circulation 55: 767–772.Google Scholar
  21. Castelli, W. P., Gordon, T., Hjortiand, M. C., Kagan, A., Doyle, J. T., Hames, C. G., Hulley, S. B., and Zukel, W. J., 1977c, Alcohol and blood lipids: The cooperative lipoprotein phenotyping study, Lancet 2: 153–155.Google Scholar
  22. Chait, A., Albers, J. J., Brunzell, J. D., and Hazzard, W. R., 1977, Type-Ill hyperlipoproteinaemia (“remnant removal disease”): Insight into the pathogenetic mechanism, Lancet 1: 1176–1178.Google Scholar
  23. Chajek, T., Stein, O., and Stein, Y., 1977, Pre- and post-natal development of lipoprotein lipase and hepatic triglyceride hydrolase activity in rat tissues. Atherosclerosis 26: 549–561.PubMedCrossRefGoogle Scholar
  24. Cheung, M. C., and Albers, J. J., 1977, The measurement of apolipoprotein A-I and A-II levels in men and women by immunoassay,J. Clin. Invest. 60: 43–50.CrossRefGoogle Scholar
  25. Deckelbaum, R. J., Lees, R. S., Small, D. M., Hedberg, S. E., and Grundy, S. M., 1977, Failure of complete bile diversion and oral bile acid therapy in the treatment of homozygous familial hypercholesterolemia, N. Engl. J. Med. 296: 465–470.Google Scholar
  26. Di Giulio, S., Boulu, R., Driieke, T., Nicolai, A., Zingraff, J., and Crosnier, J., 1977, Clofibrate treatment of hyperlipidemia in chronic renal failure, Clin. Nephrol. 8: 504–509.PubMedGoogle Scholar
  27. Eisenberg, S., and Levy, R. L, 1975, Lipoprotein metabolism, in: Advances in Lipid Research, Vol. 13 ( R. Paoletti and D. Kritchevsky, eds.), pp. 1–89, Academic Press, New York.Google Scholar
  28. Enger, S. V., Herbj«rnsen, K., Erikssen, J., and Fretland, A., 1977, High density lipoproteins (HDL) and physical activity: The influence of physical exercise, age and smoking on HDL-cholesterol and the HDL-total cholesterol ratio, Scaml.J. Clin. Lab. Invest. 37: 251–255.Google Scholar
  29. Farah, J. R., Kwiterovich, P. O., Jr., and Neill, C. A., 1977, Dose-effect relation of cholestyramine in children and young adults with familial hypercholester- olaemia, Lancet 1: 59–63.PubMedCrossRefGoogle Scholar
  30. Farinaro, E., Stamler, J., Upton, M., Mojonnier, L., Hall, Y., Moss, D., and Berkson, D. M., 1977, Plasma glucose levels: Long-term effect of diet in the Chicago coronary prevention evaluation program, Ann. Intern. Med. 86: 147–154.Google Scholar
  31. Faust, J. R., Goldstein, J. L., and Brown, M. S., 1977, Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured mouse adrenal cells, J.Biol. Chem. 252: 4861–4871.PubMedGoogle Scholar
  32. Fielding, C. J., and Havel, R. J., 1977, Lipoprotein lipase. Arch. Pathol. Lab. Med. 101: 225–229.Google Scholar
  33. Fielding, P. E., Shore, V. G., and Fielding, C. J., 1977, Lipoprotein lipase: Isolation and characterization of a second enzyme species from postheparin plasma, Biochemistry 16: 1896–1900.Google Scholar
  34. Freeman, M., Kuiken, L., Ragland, J. B., and Sabesin, S. M., 1977, Hepatic triglyceride lipase deficiency in liver disease. Lipids 12: 443–445.PubMedCrossRefGoogle Scholar
  35. Glueck, C. J., Gartside, P. S., Steiner, P. M., Miller, M., Todhunter, T., Haaf, J., Pucke, M., Terrana, M., Fallat, R. W., and Kashyap, M. L., 1977a, Hyperal- pha- and hypobeta-lipoproteinemia in octogenarian kindreds. Atherosclerosis 27: 387–406.PubMedCrossRefGoogle Scholar
  36. Glueck, G. J., Mellies, M. J., Tsang, R. G., Kashyap, M. L., and Steiner, P. M., 1977b, Familial hypertriglyceridemia in children: Dietary management, Pediatr. Res. 11: 953–957.Google Scholar
  37. Glueck, G. J., Mellies, M. J., Tsang, R. G., and Steiner, P. M., 1977c, Low and high density lipoprotein cholesterol interrelationships in neonates with low density lipoprotein cholesterol the 10th percentile and in neonates with high density lipoprotein cholesterol the 90th percentile, Pediatr. Res. 11: 957–959.PubMedCrossRefGoogle Scholar
  38. Glueck, G. J., Tsang, R. G., Fallat, R. W., and Mellies, M. J., 1977d, Diet in children heterozygous for familial hypercholesterolemia. Am. J. Dis. Child. 131: 162–166.Google Scholar
  39. Glueck, C. J., Tsang, R. C., Fallat, R. W., and MeUies, M. J., 1977e, Therapy of familial hypercholesterolemia in childhood: Diet and cholestyramine resin for 24 to 36 months, Pediatrics 60: 433–441.Google Scholar
  40. Glueck, C. J., Gartside, P. S., Miller, L., Steiner, P. M., Todhunter, T., Terrana, M., Haaf, J., and Kashyap, M. L., 1978, Octogenarian kindred: Hyper-a- lipoproteinemia, Prev. Med. 7: 1–14.Google Scholar
  41. Goldberg, A. P., Sherrard, D. J., Haas, L. B., and Brunzell, J. D., 1977, Control of Clofibrate toxicity in uremic hypertriglyceridemia, Clin. Pharmacol. Ther. 21: 317–325.Google Scholar
  42. Goldstein, J. L., and Brown, M. S., 1977a, The low-density lipoprotein pathway and its relation to atherosclerosis, Annu. Rev. Biochem. 46: 897–930.CrossRefGoogle Scholar
  43. Goldstein, J. L., and Brown, M. S., 1977b, Atherosclerosis: The low-density lipoprotein receptor hypothesis. Metabolism 26: 1257–1275.Google Scholar
  44. Goldstein, J. L., Anderson, R. G. W., Buja, L. M., Basu, S. K., and Brown, M. S., 1977, Overloading human aortic smooth muscle cells with low density lipo- protein-cholesteryl esters reproduces features of atherosclerosis in vitro, J. Clin. Invest. 59: 1196–1202.CrossRefGoogle Scholar
  45. Goodman, D. S., 1976, Disorders of lipid and lipoprotein metabolism, in: The Year in Metabolism 1975–1976 ( N. Freinkel, ed.), pp. 153–180, Plenum Medical Book Company, New York.Google Scholar
  46. Goodman, D. S., 1978, Disorders of lipid and lipoprotein metabolism, in: The Year in Metabolism 1977 ( N. Freinkel, ed.), pp. 183–218, Plenum Medical Book Company, New York.Google Scholar
  47. Gordon, R. S., Jr., Forman, S., Canner, P., Berge, K., and Miller, D., 1977, Gallbladder disease as a side effect of drugs influencing lipid metabolism: Experience in the Coronary Drug Project, N. Engl. J. Med. 296: 1185–1190.Google Scholar
  48. Gordon, T., Castelli, W. P., Hjortland, M. C., Kannel, W. B., and Dawber, T. R., 1977, High density lipoprotein as a protective factor against coronary heart disease: The Framingham Study, Am. J. Med. 62: 707–714.Google Scholar
  49. Gotto, A. M., Jr., DeBakey, M. E., Foreyt, J. P., Scott, L. W., and Thornby, J. I., 1977, Dietary treatment of type IV hyperlipoproteinemia,J. Am. Med. Assoc. 237: 1212–1215.CrossRefGoogle Scholar
  50. Green, P. H. R., Tall, A. R., and Glickman, R. M., 1978, Rat intestine secretes discoid high density lipoprotein,J. Clin. Invest. 61: 528–534.CrossRefGoogle Scholar
  51. Grundy, S. M., and Mok, H. Y. I., 1976, Chylomicron clearance in normal and hyperlipidemic man, Metabolism 25: 1225–1239.PubMedCrossRefGoogle Scholar
  52. Gyntelberg, F., Brennan, R., Holloszy, J. O., Schonfeld, G., Rennie, M. J., and Weidman, S. W., 1977, Plasma triglyceride lowering by exercise despite increased food intake in patients with type IV hyperlipoproteinemia. Am. J. Clin. NiUr. 30: 716–720.Google Scholar
  53. Hauser, H., Kostner, G., Muller, M., and Skrabal, P., 1977, The structure and morphology of the abnormal serum lipoprotein-X, Biochim. Biophys. Acta 489: 247–261.Google Scholar
  54. Havel, R. J., and Kane, J. P., 1973, Primary dysbetalipoproteinemia: Predominance of a specific apolipoprotein species in triglyceride-rich lipoproteins, Proc. Natl. Acad. Sci. U.S.A. 70: 2015–2019.Google Scholar
  55. Heiberg, A., and Slack, J., 1977, Family similarities in the age at coronary death in familial hypercholesterolemia, Br. Med. J. 2: 493–495.PubMedCrossRefGoogle Scholar
  56. Heinen, R. J., Herbert, P. N., Frederickson, D. S., Forte, T., and Lindgren, F. T., 1978, Properties of the plasma very low and low density lipoproteins in Tangier disease, J.Clin. Invest. 61: 120–132.PubMedCrossRefGoogle Scholar
  57. Ho, Y. K., Faust, J. R., Bilheimer, D. W., Brown, M. S., and Goldstein, J. L., 1977, Regulation of cholesterol synthesis by low density lipoprotein in isolated human lymphocytes: Comparison of cells from normal subjects and patients with homozygous familial hypercholesterolemia and abetalipoproteinemia, J. Exp. Med. 145: 1531–1549.Google Scholar
  58. Jackson, R. L., Morrisett, J. D., and Gotto, A. M., Jr., 1976, Lipoprotein structure and metabolism, Physiol. Rev. 56: 259–316.Google Scholar
  59. Jackson, R. L., Baker, H. N., Gilliam, E. B., and Gotto, A. M., Jr., 1977, Primary structure of very low density apolipoprotein G-II of human plasma, Proc. Natl. Acad. Sci. U.S.A. 74: 1942–1945.Google Scholar
  60. Johansson, B. G., and Medhus, A., 1974, Increase in plasma «-lipoproteins in chronic alcoholics after acute abuse. Acta Med. Scand. 195: 273–277.PubMedCrossRefGoogle Scholar
  61. Kane, J. P., Sata, T., Hamilton, R. L., and Havel, R. J., 1975, Apoprotein composition of very low density lipoproteins of human serum, J. Clin. Invest. 56: 1622–1634.CrossRefGoogle Scholar
  62. Kashyap, M. L., Srivastava, L. S., Chen, C. Y., Perisutti, G., Campbell, M., Lutmer, R. F., and Glueck, C. J., 1977, Radioimmunoassay of human apolipo protein CII: A study in normal and hypertriglyceridemic sulgects, J. Clin. Invest. 60: 171–180.CrossRefGoogle Scholar
  63. Katz, S. S., Small, D. M., Brook, J. G., and Lees, R. S., 1977, The storage lipids in Tangier disease: A physical chemical study,J. Clin. Invest. 59: 1045–1054.CrossRefGoogle Scholar
  64. Kinnunen, P. K. J., Jackson, R. L., Smith, L. C., Gotto, A. M., Jr., and Sparrow, J. T., 1977, Activation of lipoprotein lipase by native and synthetic fragments of human plasma apolipoprotein C-II, Proc. Natl. Acad. Sci. U.S.A. 74: 4848–4851.CrossRefGoogle Scholar
  65. Kushwaha, R. S., Hazzard, W. R., Wahl, P. W., and Hoover, J. J., 1977a, Type III hyperlipoproteinemia: Diagnosis in whole plasma by apolipoprotein-E immunoassay, Ann. Intern. Med. 87: 509–516.Google Scholar
  66. Kushwaha, R. S., Hazzard, W. R., Gagne, C., Chait, A., and Albers, J. J., 1977b, Type III hyperlipoproteinemia: Paradoxical hypolipidemic response to estrogen, Ann. Intern. Med. 87: 517–525.Google Scholar
  67. Lampman, R. M., Santinga, J. T., Hodge, M. F., Block, W. D., Flora, J. D., Jr., and Bassett, D. R., 1977, Comparative effects of physical training and diet in normalizing serum lipids in men with type IV hyperlipoproteinemia. Circulation 55: 652–659.PubMedGoogle Scholar
  68. Lampman, R. M., Santinga, J. T., Bassett, D. R., Mercer, N., Block, W. D., Flora, J. D., Jr., Foss, M. L., and Thorland, W. G., 1978, Effectiveness of unsupervised and supervised high intensity physical training in normalizing serum lipids in men with type IV hyperlipoproteinemia, Circidation 57: 172–180.Google Scholar
  69. Lees, A. M., Mok, H. Y. L, Lees, R. S., McCluskey, M. A., and Grundy, S. M., 1977, Plant sterols as cholesterol-lowering agents: Clinical trials in patients with hypercholesterolemia and studies of sterol balance. Atherosclerosis 28: 325–338.Google Scholar
  70. LeLorier, J., DuBreuil-Quidoz, S., Lussier-Cacan, S., Huang, Y.-S., and Davignon, J., 1977, Diet and probucol in lowering cholesterol concentrations: Additive effects on plasma cholesterol concentrations in patients with familial type II hyperlipoproteinemia, Arch. Intern. Med. 137: 1429–1434.Google Scholar
  71. Leonhardt, E. T. G., 1978, Effects of vitamin E on serum cholesterol and triglycerides in hyperlipidemic padents treated with diet and clofibrate, Am. J. Clin. Nutr. 31: 100–105.Google Scholar
  72. Mabuchi, H., Ito, S., Haba, T., Ueda, K., Ueda, R., Tatami, R., Kametani, T., Koizumi, J., Ohta, M., Miyamoto, S., Takeda, R., and Takegoshi, T., 1977a, Discrimination of familial hypercholesterolemia and secondary hypercholesterolemia by Achilles’ tendon thickness. Atherosclerosis 28: 61–68.PubMedCrossRefGoogle Scholar
  73. Mabuchi, H., Haba, T., Ueda, K., Ueda, R., Tatami, R., Ito, S., Kametani, T., Koizumi, J., Miyamoto, S., Ohta, M., Takeda, R., Takegoshi, T., and Take- shita, H., 1977b, Serum lipids and coronary heart disease in heterozygous familial hypercholesterolemia in the Hokuriku district of Japan, Atherosclerosis 28: 417–423.PubMedCrossRefGoogle Scholar
  74. Mahley, R. W., and Innerarity, T. L., 1977, Interaction of canine and swine lipoproteins with the low density lipoprotein receptor of fibroblasts as correlated with heparin Jangañese precipitability, J. Biol Chem. 252: 3980–3986.PubMedGoogle Scholar
  75. Mahley, R. W., Innerarity, T. L., Pitas, R. E., Weisgraber, K. H., Brown, J. H., and Gross, E., 1977, Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in arginine-rich and B apoproteins,J. Biol. Chem. 252: 7279–7287.Google Scholar
  76. Mann, J. I., Harding, P. A., Turner, R. C., and Wilkinson, R. H., 1977, A comparison of cholestyramine and nicotinic acid in the treatment of familial type II hyperlipoproteinaemia, Br. J. Clin. Pharmacol. 4: 305–308.Google Scholar
  77. Miller, N. E., Thelle, D. S., F0rde, O. H., and Mjs, O. D., 1977a, The Troms0 Heart Study—High-density lipoprotein and coronary heart-disease: A prospective case-control study. Lancet 1: 965–968.Google Scholar
  78. Miller, N. E., Weinstein, D. B., Carew, T. E., Koschinsky, T., and Steinberg, D., 1977b, Interaction between high density and low density lipoproteins during uptake and degradation by cultured human fibroblasts,J. Clin. Invest. 60: 78–88.CrossRefGoogle Scholar
  79. Minamisono, T., Wada, M., Akamatsu, A., Okabe, M., Handa, Y., Morita, T., Asagami, C., Naito, H. K., Nakamoto, S., Lewis, L. A., and Mise, J., 1978, Dyslipoproteinemia (a remnant lipoprotein disease) in uremic patients on hemodialysis, Clin. Chim. Acta 84: 163–172.CrossRefGoogle Scholar
  80. Mishkel, M. A., and Crowther, S. M., 1977, Long-term therapy of diet-resistant hypercholesterolemia with colestipol, Curr. Ther. Res. 22: 398–412.Google Scholar
  81. Mjs, O. D., Thelle, D. S., F0rde, O. H., and Vik-Mo, H., 1977, Family study of high density lipoprotein cholesterol and the reladon to age and sex: The Troms0 Heart Study, Acta Med. Scand. 201: 323–329.CrossRefGoogle Scholar
  82. Montes, A., and Knopp, R. H., 1977, Lipid metabolism in pregnancy. IV. C apoprotein changes in very low and intermediate density lipoproteins,J. Clin. Endocrinol. Metab. 45: 1060–1063.CrossRefGoogle Scholar
  83. Mordasini, R., Frey, F., Flury, W., Klose, G., and Greten, H., 1977, Selecdve deficiency of hepatic triglyceride lipase in uremic patients, N. Engl. J. Med. 297: 1362–1366.Google Scholar
  84. Morrison, A., deGroot, I., Edwards, B. K., Kelly, K. A., Rauh, J. L., Mellies, M. J., and Glueck, C. J., 1977, Plasma cholesterol and triglyceride levels in 6775 school children, ages 6–17, Metabolism 26: 1199–1211.PubMedCrossRefGoogle Scholar
  85. Moutafis, C. D., Simons, L. A., Myant, N. B., Adams, P. W., and Wynn, V., 1977, The effect of cholestyramine on the faecal excretion of bile acids and neutral steroids in familial hypercholesterolemia. Atherosclerosis 26: 329–334.PubMedCrossRefGoogle Scholar
  86. Nikkilä, E. A., Huttunen, J. K., and Ehnholm, C., 1977a, Postheparin plasma lipoprotein lipase and hepatic lipase in diabetes mellitus: Relationship to plasma triglyceride metabolism, Diabetes 26: 11–21.Google Scholar
  87. Nikkilä, E. A., Huttunen, J. K., and Ehnholm, C., 1977b, Effect of Clofibrate on postheparin plasma triglyceride lipase activities in patients with hypertriglyceridemia, Metabolism 26: 179–186.PubMedCrossRefGoogle Scholar
  88. Osborne, J. C., Jr., and Brewer, H. B., Jr., 1977, The plasma lipoproteins. Adv. Protein Chem. 31: 253–337.Google Scholar
  89. Patsch, J. R., Aune, K. C., Gotto, A. M., Jr., and Morrisett, J. D., 1977a, Isolation, chemical characterization, and biphysical properties of three different abnormal lipoproteins: LP-Xi, LP-Xg, and LP-Xg,J. Biol Chem. 252: 2113–2120.Google Scholar
  90. Patsch, J. R., Jackson, R. L., and Gotto, A. M., Jr., 1977b, Evaluation of the classical methods for the diagnosis of type III hyperlipoproteinemia, Klin. Wochenschr. 55: 1025–1030.Google Scholar
  91. Patsch, J. R., Yeshurun, D., Jackson, R. L., and Gotto, A. M., Jr., 1977c, Effects of Clofibrate, nicotinic acid and diet on the properties of the plasma lipoproteins in a subject with type III hyperlipoproteinemia, Am.J. Med. 63: 1001–1009.Google Scholar
  92. Raymond, T. L., Connor, W. E., Lin, D. S., Warner, S., Fry, M. M., and Connor, S. L., 1977, The interaction of dietary fibers and cholesterol upon the plasma lipids and lipoproteins, sterol balance, and bowel function in human subjects, J. Clin. Invest. 60: 1429–1437.CrossRefGoogle Scholar
  93. Reichl, D., Myant, N. B., and Pflug, J. J., 1977, Concentration of lipoproteins containing apolipoprotein B in human peripheral lymph, Biochim. Biophys. Acta 489: 98–105.Google Scholar
  94. Ross, R., and Glomset, J. A., 1976, The pathogenesis of atherosclerosis, N. Engl.J. Med. 295:369–377, 420–425.Google Scholar
  95. Ross, R., and Harker, L., 1976, Hyperlipidemia and atherosclerosis: Chronic hyperlipidemia initiates and maintains lesions by endothelial cell desquamation and lipid accumulation, Science 193: 1094–1100.Google Scholar
  96. Rössner, S., Mettinger, K. L., Kjellin, K. G., Siden, A., and Söderström, C. E., 1978, Normal serum-cholesterol but low H.D.L.-cholesterol concentration in young patients with ischaemic cerebrovascular disease. Lancet 1: 577–579.PubMedCrossRefGoogle Scholar
  97. Samuel, P., Grouse, J. R., and Ahrens, E. H., Jr., 1978, Evaluation of an isotope ratio method for measurement of cholesterol absorption in man, J. Lipid Res. 19: 82–93.PubMedGoogle Scholar
  98. Sanfelippo, M. L., Swenson, R. S., and Reaven, G. M., 1977, Reduction of plasma triglycerides by diet in subjects with chronic renal failure. Kidney Int. 11: 54–61.PubMedCrossRefGoogle Scholar
  99. Seidel, D., 1977, Studien zur Charakterisierung und zum Stoffwechsel des Lipo- protein-X ( LP-X), des abnormen Lipoproteins der Cholestase, Klin. Wochenschr. 55: 611–623.Google Scholar
  100. Shelburne, F. A., and Quarfordt, S. H., 1977, The interaction of heparin with an apoprotein of human very low density lipoprotein, J. Clin. Invest. 60: 944–950.CrossRefGoogle Scholar
  101. Slack, J., Noble, N., Meade, T. W., and North, W. R. S., 1977, Lipid and lipoprotein concentrations in 1604 men and women in working populations in north-west London, Br. Med. J. 2: 353–356.Google Scholar
  102. Srinivasan, S. R., Frerichs, R. R., Webber, L. S., and Berenson, G. S., 1976, Serum lipoprotein profile in children from a biracial community: The Bogalusa Heart Study, Circulation 54: 309–318.Google Scholar
  103. Stanbury, J. B., Wyngaarden, J. B., and Fredrickson, D. S., 1978, The Metabolic Basis oj Inherited Disease, 4th ed., pp. 544–865, McGrawTiill, New York.Google Scholar
  104. Stanhope, J. M., Sampson, V. M., and Clarkson, P. M., 1977, High-density- lipoprotein cholesterol and other serum lipids in a New Zealand biracial adolescent sample: The Wairoa Cx)llege Survey, Lancet 1: 968–970.CrossRefGoogle Scholar
  105. Stein, E. A., 1977, Familial hypo-j8–lipoproteinemia: A family detected by cord blood tests. Am. J. Dis. Child. 131: 1363–1365.Google Scholar
  106. Sternowsky, FL j., Gaertner, U., Stahnke, N., and Kaukel, E., 1977, Juvenile familial hypertriglyceridemia and growth retardation: Clinical and biochemical observations in tin ee siblings, Eur. J. Pediatr. 125: 59–70.Google Scholar
  107. Streja, D., Kallai, M. A., and Steiner, G., 1977, The metabolic heterogeneity of human very low density lipoprotein triglyceride, Metabolism 26: 1333–1344.PubMedCrossRefGoogle Scholar
  108. Taylor, K. G., Holdsworth, G., and Galton, D. J., 1977, Glofibrate increases lipoprotein-lipase activity in adipose tissue of hypertriglyceridaemic patients. Lancet 2: 1106–1107.PubMedCrossRefGoogle Scholar
  109. Thompson, G. R., Spinks, T., Ranicar, A., and Myant, N. B., 1977, Non-steady- state studies of low-density-lipoprotein turnover in familial hypercholester- olaemia, Clm. Sci. MoL Med. 52: 361–369.Google Scholar
  110. Utermann, G., Jaeschke, M., and Menzel, J., 1975, Familial hyperlipoproteinemia type IIL Deficiency of a specific apolipoprotein (apo E-III) in the very-low- density lipoproteins, FEBS Lett. 56: 352–355.PubMedCrossRefGoogle Scholar
  111. Utermann, G., Ganzler, H., Hees, M., Jaeschke, M., Miihlfellner, G., Schoenborn, W., and Vogelberg, K. H., 1977a, Studies on the metabolic defect in broad- disease (hyperlipoproteinaemia type III), Clin. Genet. 12: 139–154.PubMedCrossRefGoogle Scholar
  112. Utermann, G., Hees, M., and Steinmetz, A., 1977b, Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man. Nature (London) 269: 604–607.CrossRefGoogle Scholar
  113. Warnick, G. R., and Albers, J. J., 1978, A comprehensive evaluation of the heparin-manganese precipitation procedure for estimating high density lipoprotein cholesterol, J. Lipid Res. 19: 65–76.PubMedGoogle Scholar
  114. West, R., and Lloyd, J. K., 1977, Cholestyramine in hypercholesterolemia. Lancet 1: 488–489.PubMedCrossRefGoogle Scholar
  115. Yano, K., Rhoads, G. G., and Kagan, A., 1977, Coffee, alcohol, and risk of coronary heart disease among Japanese men living in Hawaii, N. Engl. J. Med. 297: 405–409.Google Scholar
  116. Zilversmit, D. B., 1972, A single blood sample dual isotope method for the measurement of cholesterol absorption in rats, Proc. Soc. Exp. Biol. Med. 140: 862–865.Google Scholar

Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • DeWitt S. Goodman
    • 1
  1. 1.Department of MedicineCollege of Physicians and Surgeons of Columbia UniversityNew YorkUSA

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