Disorders of Purine and Pyrimidine Metabolism

  • J. Edwin Seegmiller


Progress during the past year in the field of aberrations of purine metabolism has extended our knowledge of the metabolic consequences of a deficiency of specific enzymes and thereby allowed formulation of better understanding of possible mechanisms involved in producing the clinical diseases. Additional patients with recently described enzyme deficiencies have been identified and have served to define more precisely the range of clinical presentations to be expected in these disorders.


Uric Acid Adenosine Deaminase Serum Urate Gouty Arthritis Purine Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used in this chapter


adenosine deaminase


adenine phosphoribosyltransferase


cyclic AMP


cyclic GMP

(Con A)

concanavallin A


cytidine triphosphate


deoxyadenosine triphosphate


deoxycytidine triphosphate


deoxyguanosine triphosphate


formyglycinamide ribonucleotide


high pressure liquid chromatography


hypoxanthine-guanine phosphoribosyltransferase






purine nucleoside phosphorylase


purine 5-nucleotidase




thymidine triphosphate


uridine triphosphate


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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • J. Edwin Seegmiller
    • 1
  1. 1.Department of Medicine, School of MedicineThe University of California San DiegoLa JollaUSA

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