• Aubrey Milunsky


Needles have been introduced into the amniotic sac at least since 1881 (Lambl, 1881; Schatz, 1882; Prochownick, 1877). Successful amniocentesis for a case of polyhydramnios was noted in 1919 (Henkel, 1919). After the introduction of X rays, amniocentesis was used for placental localization by amniography (Menees et al., 1930).


Down Syndrome Amniotic Fluid Prenatal Diagnosis Spontaneous Abortion Neural Tube Defect 
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  1. Abdulla, U., Campbell, S., Dewhurst, C. J., et al., 1971, Effect of diagnostic ultrasound on maternal and fetal chromosomes, Lancet 2:829.PubMedGoogle Scholar
  2. Allen, H. H., Sergovich, F., Stuart, E. M., et al., 1974, Infants undergoing antenatal genetic diagnosis: A preliminary report. Am. J. Obstet. Gynecol. 118:310.PubMedGoogle Scholar
  3. Amarose, A. P., Wallingford, A. J., Jr., and Plötz, E. J., 1966, Prediction of fetal sex from cytologic examination of amniotic fluid, N. Engl. J. Med. 275:715.PubMedGoogle Scholar
  4. Bang, J., Nielsen, H., and Philip J., 1975, Prenatal karyotyping of twins by ultrasonically guided amniocentesis. Am.J. Obstet. Gynecol. 123:695.PubMedGoogle Scholar
  5. Berner, H. W., Jr., 1967, Amniography, an accurate way to localize the placenta: A comparison with soft tissue placentography. Obstet. Gynecol. 29:200.PubMedGoogle Scholar
  6. Berner, H. W., Seisler, E. P., and Barlow, J., 1972, Fetal cardiac tamponade: A complication of amniocentesis. Obstet. Gynecol. 40:599.PubMedGoogle Scholar
  7. Bevis, D. C. A., 1950, Composition of liquor amnii in haemolytic disease of newborn. Lancet 2:443.PubMedGoogle Scholar
  8. Bevis, D. C. A., 1952, The antenatal prediction of haemolytic disease of the newborn. Lancet 1:395.PubMedGoogle Scholar
  9. Blajchman, M. A., Maudsley, R. F., Uchida, I., et al., 1974, Diagnostic amniocentesis and fetalmaternal bleeding. Lancet 1:993.PubMedGoogle Scholar
  10. Bobrow, M., Blackwell, N., Unrau, A. E., et al., 1971, Absence of any observed effect of ultrasonic irradiation on human chromosomes, J. Obstet. Gynaecol. Br. Commonw. 78:730.PubMedGoogle Scholar
  11. Boyd, E., Abdulla, U., Donald, I., et al., 1971, Chromosome breakage and ultrasound, Br. Med. J. 2:412.Google Scholar
  12. Broome, D. L., Kellogg, B., Weiss, B. A., et al., 1975, Needle puncture of the fetus during amniocentesis. Lancet 2:604.PubMedGoogle Scholar
  13. Broome, D. L., Wilson, M. G., Weiss, B., et al., 1976, Needle puncture of fetus: A complication of second-trimester amniocentesis, Am.J. Obstet. Gynecol. 126:247.PubMedGoogle Scholar
  14. Buckton, K. E., and Vashon Baker, N., 1972, An investigation into possible chromosome damaging effects of ultrasound on human blood cells, Br. J. Radiol. 45:340.PubMedGoogle Scholar
  15. Burnett, R. G., and Anderson, W. R., 1968, The hazards of amniocentesis, J. Iowa Med. Soc. 58:130.Google Scholar
  16. Chervin, A., Farnsworth, P. B., Freedman, W. L., et al., 1977, Amniocentesis for prenatal diagnosis: Subjective patient response, N.Y. State J. Med. 77:1406.PubMedGoogle Scholar
  17. Clayton, E. M., Feldhaus, W. D., and Whitacre, F. E., 1964, Fetal erythrocytes in the maternal circulation of pregnant women, Obstet. Gynecol. 23:915.PubMedGoogle Scholar
  18. Coakley, W. T., Hughes, D. E., Slade, J. S., et al., 1971, Chromosome aberration after exposure to ultrasound, Br. Med. J. 1:109.PubMedGoogle Scholar
  19. Cook, L. N., Shott, R. J., and Andrews, B. F., 1974, Fetal complications of diagnostic amniocentesis: A review and report of a case with pneumothorax. Pediatrics 53:421.PubMedGoogle Scholar
  20. Creasman, W. T., Lawrence, R. A., and Thiede, H. A., 1968, Fetal complications of amniocentesis, J. Am. Med. Assoc. 204:949.Google Scholar
  21. Cross, H. E., and Maumenee, A. E., 1972, Ocular trauma during amniocentesis, N. Engl. J. Med. 287:993.PubMedGoogle Scholar
  22. Curtis, J. D., Cohen, W. N., Richerson, H. R., et al., 1972, The importance of placental localization preceding amniocentesis, Obstet. Gynecol. 40:194.PubMedGoogle Scholar
  23. David, H., Weaver, J. B., and Pearson, T. F., 1975, Doppler ultrasound and fetal activity, Br. Med. J. 2:62.PubMedGoogle Scholar
  24. DeMyer, W., and Baird, I., 1969, Mortality and skeletal malformations from amniocentesis and oligohydramnios in rats: Cleft palate, clubfoot, microstomia, and adactyly, Teratology 2:33.PubMedGoogle Scholar
  25. Doran, T. A., Rudd, N. L., Gardner, H. A., et al., 1974, The antenatal diagnosis of genetic disease. Am. J. Obstet. Gynecol. 118:310.Google Scholar
  26. Egley, C. C., 1973, Laceration of fetal spleen during amniocentesis. Am. J. Obstet. Gynecol. 116:582.PubMedGoogle Scholar
  27. Emery, A. E. H., 1973, Antenatal Diagnosis of Genetic Disease, Williams and Wilkins, Baltimore.Google Scholar
  28. Finley, S. C., Varner, P. D., Vinson, P. C., et al., 1977, Participants’ reaction to amniocentesis and prenatal genetic studies, J. Am. Med. Assoc. 238:2377.Google Scholar
  29. Freda, V. J., 1965, The Rh problem in obstetrics and a new concept of its management using amniocentesis and spectrophotometric scanning of amniotic fluid. Am. J. Obstet. Gynecol. 92:341.PubMedGoogle Scholar
  30. Freda, V. J., 1966, Recent obstetrical advances in the Rh problem: Antepartum management, amniocentesis and experience with hysterotomy and surgery in utero. Bull. N. Y. Acad. Med. 42:474.PubMedGoogle Scholar
  31. Fuchs, F., 1966, Volume of amniotic fluid at various stages of pregnancy, Clin. Obstet. Gynecol. 9:449.PubMedGoogle Scholar
  32. Fuchs, F., 1971, Amniocentesis and abortion: Methods and risks, Birth Defects Orig. Art. Ser. 7:18.PubMedGoogle Scholar
  33. Fuchs, F., and Riis, P., 1956, Antenatal sex determination. Nature (London) 177:330.Google Scholar
  34. Galjaard, H., 1976, European experience with prenatal diagnosis of congenital disease: A survey of 6121 cases, Cytogenet. Cell Genet. 16:453.PubMedGoogle Scholar
  35. Galperin-Lemaitre, H., Kirsch-Volders, M., and Levi, S., 1975, Fragmentation of purified mammahan DNA molecules by ultrasound below human therapeutic doses, Humangenetik 29:61.PubMedGoogle Scholar
  36. Gassner, C. B., and Paul, R. H., 1976, Laceration of umbilical cord vessels secondary to amniocentesis, Obstet. Gynecol. 48:627.PubMedGoogle Scholar
  37. Gerbie, A. B., Nadler, H. L., and Gerbie, M. V., 1971, Amniocentesis in genetic counseling. Safety and reliability in early pregnancy, Am. J. Obstet. Gynecol. 109:765.PubMedGoogle Scholar
  38. Gerbie, A. B., and Shkolnik, A. A.. 1975, Ultrasound prior to amniocentesis for genetic counseling, Obstet. Gynecol. 46:716.PubMedGoogle Scholar
  39. Golbus, M. S., 1975, Doctor, will my baby be normal? Consultant 15:131.Google Scholar
  40. Goodlin, R. C., and Clewell, W. H., 1974, Sudden fetal death following diagnostic amniocentesis, Am. J. Obstet. Gynecol. 118:285.PubMedGoogle Scholar
  41. Grimm, E. R., 1961, Psychological tension in pregnancy, Psychosom. Med. 23:520.PubMedGoogle Scholar
  42. Grove, C. S., Rombetta, G. C., and Amstey, M., 1973, Fetal complications of amniocentesis, Am. J. Obstet. Gynecol. 115:1154.PubMedGoogle Scholar
  43. Hanid, T. K., 1975, Pneumothorax and surgical emphysema in a newborn baby caused by amniocentesis, Br. J. Obstet. Gynaecol. 82:170.PubMedGoogle Scholar
  44. Harrison, R., Campbell, S., and Craft, I., 1975, Risks of fetomaternal hemorrhage resulting from amniocentesis with and without ultrasound placental localization. Obstet. Gynecol. 46:389.PubMedGoogle Scholar
  45. Hellman, L. M., Dufifus, G. M., Donald, I., et al., 1970, Safety of diagnostic ultrasound in obst&tncs . Lancet 1 :1133. Google Scholar
  46. Henkel, M., 1919, Akutes hydramnion, leberkompression, enges becken, Punktion des hydramnion, Zentralbl. Gynaekol. 43:841.Google Scholar
  47. Henry, G., Wexler, P., and Robinson, A., 1976, Rh-immune globulin after amniocentesis for genetic diagnosis. Obstet. Gynecol. 48:557.PubMedGoogle Scholar
  48. Herrmann, J., Pallister, P. D., Gilbert, E. F., et al., 1976, Studies of malformation syndromes of man. XXXXI. B. Nosologic studies in the Hanhart and the Möbius syndrome, Eur. J. Pediatr. 122:19.PubMedGoogle Scholar
  49. Heymans, H., and Winter, S. T., 1975, Fears during pregnancy. An interview study of 200 postpartum women, Israel J. Med.. 11:1102.Google Scholar
  50. Horger, E. O., and Smythe, A. R., II, 1977, Pregnancy in women over forty. Obstet. Gynecol. 49:257.PubMedGoogle Scholar
  51. James, F., 1956, Sexing foetuses by examination of amniotic fluid. Lancet 1:202.Google Scholar
  52. Kajanoja, P., and Widholm, O., 1978, Pregnancy and delivery in women aged 40 and over. Obstet. Gynecol. 51:47.PubMedGoogle Scholar
  53. Kane, S. H., 1967, Advancing age and the primi-gravida. Obstet. Gynecol. 29:409.PubMedGoogle Scholar
  54. Karp, L. E., and Hayden, P. W., 1977, Fetal puncture during midtrimester amniocentesis. Obstet Gynecol. 49:115.PubMedGoogle Scholar
  55. Karp, L. E., and Schiller, H. S., 1977, Meconium staining of amniotic fluid at midtrimester amniocentesis. Obstet. Gynecol. 50:47s.Google Scholar
  56. Kerenyi, T. D., and Walker, B., 1977, The preventability of “bloody taps” in second trimester amniocentesis by ultrasound scanning. Obstet. Gynecol. 50:61.PubMedGoogle Scholar
  57. Kirshen, E. J., and Benirschke, K., 1973, Fetal exsanguination after amniocentesis. Obstet. Gynecol. 42:615.PubMedGoogle Scholar
  58. Klein, H. R., Potter, H. W., and Dyk, R. B., 1950, Anxiety in Pregnancy and Childbirth, Hoeber, New York.Google Scholar
  59. Lamb, M. P., 1975, Gangrene of a fetal limb due to amniocentesis, Br. J. Obstet. Gynaecol. 82:829.PubMedGoogle Scholar
  60. Lambl, D., 1881, Ein seltener Fall von Hydramnios, Zentralbl. Gynaekol. 5:329.Google Scholar
  61. Leake, R. D., Hobel, C. J., and Lachman, R. S., 1974, Neonatal pneumothorax and subcutaneous emphysema secondary to diagnostic amniocentesis. Obstet. Gynecol. 43:884.PubMedGoogle Scholar
  62. Light, H. K., and Fenster, C., 1974, Maternal concerns during pregnancy. Am. J. Obstet. Gynecol. 118:46.PubMedGoogle Scholar
  63. Liley, A. W., 1960, The technique and complications of amniocentesis, N. Z. Med. J. 59:581.PubMedGoogle Scholar
  64. Lowe, C. U., Alexander, D. Bryla, D., et al., 1978, The safety and accuracy of mid-trimester amniocentesis, U.S. Dept. of H.E.W. sGoogle Scholar
  65. Lucas, M., Mullarkey, M., and Abdulla, U., 1972, Study of chromosomes in the newborn after ultrasonic fetal heart monitoring in labour, Br. Med. J. 3:795.PubMedGoogle Scholar
  66. MacGillivray, I., Nylander, P. P. S., and Corney, G., 1975, Human Multiple Reproduction, Saunders, Philadelphia.Google Scholar
  67. Macintosh, I. J. C., and Davey, D. A., 1970, Chromosome aberrations induced by an ultrasonic fetal pulse detector, Br. Med. J. 4:92.PubMedGoogle Scholar
  68. Makowski, E. L., Prem, K. A., and Kaiser, I. H., 1956, Detection of sex of fetuses by the incidence of sex chromatin body in nuclei of cells in amniotic fluid. Science 123:542.PubMedGoogle Scholar
  69. Medical Research Council, 1977, Diagnosis of Genetic Disease by Amniocentesis during the Second Trimester of Pregnancy, Ottawa, Canada.Google Scholar
  70. Menees, T. D., Miller, J. D., and Holly, L. E., 1930, Amniography: Preliminary report, Am. J. Roentgenol. Radium Ther. 24:363.Google Scholar
  71. Mermut, S., Katayama, P., Castillo, R. D., et al., 1973, The effect of ultrasound on human chromosomes in vitro. Obstet. Gynecol. 41:4.PubMedGoogle Scholar
  72. Milunsky, A., 1973, The Prenatal Diagnosis of Hereditary Disorders, Thomas, Springfield, Illinois.Google Scholar
  73. Milunsky, A., 1976, Current concepts in genetics: Prenatal diagnosis of genetic disorders, N. Engl. J. Med. 295:377.PubMedGoogle Scholar
  74. Milunsky, A., 1977, Know Your Genes, Houghton Mifflin, Boston.Google Scholar
  75. Milunsky, A., and Atkins, L., 1974, Prenatal diagnosis of genetic disorders. An analysis of experience with 600 cases, J. Am. Med. Assoc. 230:232.Google Scholar
  76. Milunsky, A., 1979, Hazards of amniocentesis. Lancet 1:546.PubMedGoogle Scholar
  77. Milunsky, A., Alpert, fe., Neff, R., et al., 1979, Prenatal diagnosis of neural tube defects. IV. Maternal serum alpha-fetoprotein screening. Obstet. Gynecol., in press.Google Scholar
  78. Misenheimer, H. R., 1966, Fetal hemorrhage associated with amniocentesis. Am. J. Obstet. Gynecol. 94:1133.Google Scholar
  79. Miskin, M., Doran, T. A., Rudd, N., et al., 1974, Use of ultrasound for placental localization in genetic amniocentesis. Obstet. Gynecol. 43:872.PubMedGoogle Scholar
  80. Morrison, I., 1975, The elderly Primigravida, Am. J. Obstet. Gynecol. 121:465.PubMedGoogle Scholar
  81. Mulcahy, R., and Knaggs, J. F., 1964, Effect of age, parity and cigarette smoking on outcome of pregnancy, Am. J. Obstet. Gynecol. 101:844.Google Scholar
  82. Nadler, H. L., 1969, Prenatal detection of genetic defects, 7. Pediatr. 74:132.Google Scholar
  83. Nadler, H. L., and Gerbie, A. B., 1970, Role of amniocentesis in the intrauterine detection of genetic disorders, N. Engl. J. Med. 282:596.PubMedGoogle Scholar
  84. The NICHD National Registry for Amniocentesis Study Group, 1976, Midtrimester amniocentesis for prenatal diagnosis. Safety and Accuracy, J. Am. Med. Assoc. 236:1471.Google Scholar
  85. Opitz, J. M., Laxova, R., and Herrmann, J., 1978, Intrauterine amputations after amniocentesis. Lancet 1:716.PubMedGoogle Scholar
  86. Paul, J. D., Gahres, M. G., Alpert, S. W., et al., 1963, Placenta localization using CR51 tagged erythrocytes. Obstet. Gynecol. 21:33.PubMedGoogle Scholar
  87. Prasad, N., Prasad, R., Bushong, S. C., et al., 1976, Ultrasound and mammalian DNA, Lancet 1:1181.PubMedGoogle Scholar
  88. Prochownick, L., 1877, Beiträge zur Leptre vom Fruchtwasser und seiner Entsehung, Arch. Gynaekol. 11:304.Google Scholar
  89. Queenan, J. T., 1966, Amniocentesis and transamniotic fetal transfusion for Rh disease, Clin. Obstet. Gynecol. 9:491.PubMedGoogle Scholar
  90. Queenan, J. T., and Adams, D. W., 1965, Aniniocentesis for prenatal diagnosis of erythroblastosis fetalis. Obstet. Gynecol. 25:302.PubMedGoogle Scholar
  91. Rehder, H., and Weitzel, H., 1978, Intrauterine amputations after amniocentesis. Lancet 1:382.PubMedGoogle Scholar
  92. Richards, I. D. G., Mcintosh, H. T., and Sweenie, S., 1972, A genetic study of anencephaly and spina bifida in Glasgow, Devel. Med. Child. Neurol. 14:626.Google Scholar
  93. Rickwood, A. M. K., 1977, A case of ileal atresia and ileocutaneous fistula caused by amniocentesis, J.Pediatr. 91:312.PubMedGoogle Scholar
  94. Riis, P., and Fuchs, F., 1960, Antenatal determination of fetal sex in prevention of hereditary diseases. Lancet 2:180.Google Scholar
  95. Riis, P., and Fuchs, F., 1966, Sex chromatin and antenatal sex diagnosis, in: The Sex Chromatin (K. L. Moore, ed.), p. 220, Saunders, London.Google Scholar
  96. Robertson, J. G., 1964, Examination of amniotic fluid in Rhesus isoimmunization, Br. Med. J. 2:147.PubMedGoogle Scholar
  97. Robinson, J., Tennes, K., and Robinson, A., 1975, Amniocentesis: Its impact on mothers and infants: A one-year follow-up study, Clin. Genet. 8:97.PubMedGoogle Scholar
  98. Ron, M., Anteby, S., Diamant, Y. Z., et al., 1974, Fetal distress following amniocentesis. Int. J. Gynecol. Obstet. 12:172.Google Scholar
  99. Rott, H.-D., and Söldner, R., 1973, The effect of ultrasound on human chromosomes in vitro, Humangenetik 20:103.PubMedGoogle Scholar
  100. Ryan, G. T., Faco, G., Ivy, R., et al., 1972, Fetal bleeding as a major hazard of amniocentesis. Obstet. Gynecol. 40:702.PubMedGoogle Scholar
  101. Tachdjian, M. O., 1972, Pediatric Orthopedics, Vol. 2, Philadelphia. SGoogle Scholar
  102. Schatz, F., 1882, Eine besondere Art von ein seitiger Polyhydramnie mit anderseitiger Oligohydramnie bei einaguen Zwillingen, Arch. Gynaekol. 19:329.Google Scholar
  103. Scrimgeour, J. B., 1973, Amniocentesis: Technique and complications, in: Antenatal Diagnosis of Genetic Disease (A. E. H. Emergy, ed.), p. H, Williams and Wilkins, Baltimore.Google Scholar
  104. Seller, M., 1977, Dark-brown amniotic fluid, Lancet 2:983.PubMedGoogle Scholar
  105. Serr, D. M., Sachs, L., and Danon, M., 1955, Diagnosis of sex before birth using cells from the amniotic fluid. Bull. Res. Counc. Isr. 58:137.Google Scholar
  106. Shettles, L. B., 1956, Nuclear morphology of cells in human amniotic fluid in relation to sex of infant, Am.J. Obstet. Gynecol. 71:834.PubMedGoogle Scholar
  107. Simpson, N. E., Dallaire, L., Miller, J. R., et al., 1976, Prenatal diagnosis of genetic disease in Canada: Report of a collaborative study. Can. Med. Assoc. J. 115:739.PubMedGoogle Scholar
  108. Smythe, G. E., and MacRae, D. J., 1975, Doppler ultrasound and fetal hazard. Lancet 2:134.PubMedGoogle Scholar
  109. Steele, M. W., and Breg, W. R., Jr., 1966, Chromosome analysis of human amniotic fluid cells. Lancet 1:383.PubMedGoogle Scholar
  110. Turnbull, A. C., and Bantock, H., 1979, Hazards of amniocentesis. Lancet 1:546.Google Scholar
  111. Valenti, C., Schutta, E. F., and Kehaty, T., 1969, Cytogenetic diagnosis of Down’s syndrome in utero, J.Am. Med. Assoc. 207:1513.Google Scholar
  112. Watts, P. L., and Stewart, C. R., 1972, The effect of fetal heart monitoring by ultrasound on maternal and fetal chromosomes, J. Obstet. Gynaecol. Br. Commonw. 79:715.PubMedGoogle Scholar
  113. Werch, A., 1976, Amniocentesis: Indications, technic, and complications. South. Med. J. 69:824.PubMedGoogle Scholar
  114. Williams, E. A., and Stallworthy, J. A., 1952, Simple method of internal tocography. Lancet 1:330.PubMedGoogle Scholar
  115. Wiltchik, S. G., Schwarz, R. H., and Emich, J. P., Jr., 1966, Amniography for placental localization, Obstet. Gynecol. 28:641.PubMedGoogle Scholar
  116. Young, P. E., Carson, K. F., Prichard, L. L., et al., 1974, A technique for obtaining precise chromosome and bilirubin studies on amniotic fluid in twin pregnancy, J. Reprod. Med. 13:163.PubMedGoogle Scholar

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© Aubrey Milunsky 1979

Authors and Affiliations

  • Aubrey Milunsky
    • 1
    • 2
    • 3
  1. 1.Department of PediatricsHarvard Medical SchoolBostonUSA
  2. 2.Genetics DivisionEunice Kennedy Shriver CenterWalthamUSA
  3. 3.Children’s ServiceMassachusetts General HospitalBostonUSA

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