Diagnosis, Treatment, and Prevention of Isoimmune Hemolytic Disease of the Fetus

  • Fredric D. FrigolettoJr.
  • Irving Umansky


The dramatic progress in management and prevention of hemolytic disease of the fetus and newborn due to Rh0(D) isoimmunization is well documented in the medical literature. It began almost four decades ago with the discovery of the Rh0(D) antigen and its association with erythroblastosis fetalis. Preventing the disease in most patients became a possibility with the licensing of Rh Immune Globulin in 1968, and it was hoped by many at that time that isoimmune hemolytic disease due to anti-D would be totally eradicated. Unfortunately, this has not been the case; Rh0(D) Immune Globulin has reduced the sensitization rate by 90%.


Ectopic Pregnancy Immune Globulin Exchange Transfusion Salvage Rate Hemolytic Disease 
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Copyright information

© Aubrey Milunsky 1979

Authors and Affiliations

  • Fredric D. FrigolettoJr.
    • 1
    • 2
  • Irving Umansky
    • 3
    • 4
    • 5
    • 6
  1. 1.Department of ObstetricsBoston Hospital for WomenUSA
  2. 2.Department of Obstetrics-GynecologyHarvard Medical SchoolBostonUSA
  3. 3.Department of PediatricsHarvard Medical SchoolUSA
  4. 4.Blood Grouping LaboratoryCenter for Blood ResearchUSA
  5. 5.Department of MedicineChildren’s Hospital Medical CenterUSA
  6. 6.Department of HematologyBoston Hospital for WomenBostonUSA

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