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Diagnosis, Treatment, and Prevention of Isoimmune Hemolytic Disease of the Fetus

  • Fredric D. FrigolettoJr.
  • Irving Umansky

Abstract

The dramatic progress in management and prevention of hemolytic disease of the fetus and newborn due to Rh0(D) isoimmunization is well documented in the medical literature. It began almost four decades ago with the discovery of the Rh0(D) antigen and its association with erythroblastosis fetalis. Preventing the disease in most patients became a possibility with the licensing of Rh Immune Globulin in 1968, and it was hoped by many at that time that isoimmune hemolytic disease due to anti-D would be totally eradicated. Unfortunately, this has not been the case; Rh0(D) Immune Globulin has reduced the sensitization rate by 90%.

Keywords

Ectopic Pregnancy Immune Globulin Exchange Transfusion Salvage Rate Hemolytic Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Allen, F. J., Jr., 1954, Erythroblastosis fetalis. IX. The problems of stillbirth, 251:453.Google Scholar
  2. Bowman, J. M., 1967, Modern Management of the Rh Problem (J. T. Queenan, ed.), p. 267, Hoeber, New York.Google Scholar
  3. Bowman, J. M., 1975, Rh erythroblastosis fetaUs 1975, Current Probl. Pediat. Hematol., 29.Google Scholar
  4. Bowman, J., 1976, Winnipeg Antenatal Prophylaxis Trial, in: Symposium on Rh Antibody Mediated Immunosuppression, pp. 55–58, Ortho Diagnostics, Raritan N.J.Google Scholar
  5. Bowman, J. M., Peddle, L. J., and Anderson, C., 1968, Plasmapheresis in severe Rh isoimmunization, Vox Sang 15:272.PubMedCrossRefGoogle Scholar
  6. Center for Disease Control, 1976, Rh Hemolytic Disease Surveillance Annual Summary.Google Scholar
  7. Clarke, C. A., 1971, Prevention of Rh haemolytic Disease: Final results of the “high-risk” clinical trial, Br. Med. J. 2:607.CrossRefGoogle Scholar
  8. Clarke, C. A., Bradley, J., Elson, C. J., et al., 1970, Intensive plasmapheresis as a therapeutic measure in rhesus immunized women, Lancet 1:793.PubMedCrossRefGoogle Scholar
  9. Diamond, L. K., 1966, personal communication.Google Scholar
  10. Fraser, I. D., Bothamley, J. E., Bennett, M. O., et al., 1976, Intensive antenatal plasmapheresis in severe rhesus isoimmunization, Lancet 1:6.PubMedCrossRefGoogle Scholar
  11. Freda, V. J., 1965, The Rh problem in obstetrics and a new concept of its management using amniocentesis and spectrophotometric scanning of amniotic fluid. Am. J. Obstet. Gynecol. 92:341.PubMedGoogle Scholar
  12. Freda, V. J., 1971, Rh immunization—Experience with full term pregnancies, Clin. Obstet. Gynecol. 14:594.PubMedCrossRefGoogle Scholar
  13. Frigoletto, F. D., 1974, Management and prevention of erythroblastosis fetalis, Clin. Perinat. 1:321.Google Scholar
  14. Gusdon, J. P., and Withrow, C., 1973, Possible ameliorating effects of erythroblastosis by promethazine hydrochloride, Am.J. Obstet. Gynecol. 117:1101.PubMedGoogle Scholar
  15. Henry, G., Wexler, P., and Robinson, A., 1976, Rh immune globulin after genetic amniocentesis. Obstet. Gynecol. 48:557.PubMedGoogle Scholar
  16. Hobbins, J. C., Davis, C. D., and Webster, J., 1975, A new technique utilizing ultrasound to aid in intrauterine transfusion, J. Clin. Ultrasound 4:135.CrossRefGoogle Scholar
  17. Liley, A. W., 1961, Liquor amnii analysis in the management of the pregnancy complicated by rhesus sensitization. Am. J. Obstet. Gynecol. 82:1359.PubMedGoogle Scholar
  18. Liley, A. W., 1963, Errors in the assessment of haemolytic disease from amniotic fluid. Am. J. Obstet. Gynecol. 86:485.PubMedGoogle Scholar
  19. Lin-Fu, J. S., 1975, Prevention of hemolytic disease of the fetus and newborn due to Rh isoimmunization, DHEW Publ. (HSA) 75:5125.Google Scholar
  20. Lucey, J. F., 1968, Diagnosis and treatment: Current indications and results of fetal transfusions. Pediatrics 41:139.PubMedGoogle Scholar
  21. Mollison, P. L., 1972, Blood Transfusion in Clinical Medicine, p. 628, Blackwell Scientific Publications, London.Google Scholar
  22. Nadler, H. L., 1971, Indications for amniocentesis in the early prenatal detection of genetic disorders, Birth Defects: Orig. Art. Ser. VII, 5.Google Scholar
  23. Parkman, R., Mosier, D., Umansky, I., et al., 1974, Graft vs. host disease after intrauterine and exchange transfusions for hemolytic disease of the newborn, N. Engl. J. Med. 290:359.PubMedCrossRefGoogle Scholar
  24. Queenan, J. T., 1966, Amniocentesis and transamniotic fetal transfusion for Rh disease, Clin. Obstet. Gynecol. 9:941.Google Scholar
  25. Queenan, J. T., Shah, S., Kubarych, S. F., et al., 1971, Role of induced abortion in rhesus immunization. Lancet 1:815.PubMedCrossRefGoogle Scholar
  26. Scott, J. R., Beer, A. E., Guy, R., et al., 1977, Pathogenesis of Rh immunization in primigravidas. Obstet. Gynecol. 49:9.PubMedGoogle Scholar
  27. Turner, J. H., Hutchinson, D. L., Hayashi, T. T., et al., 1975, Fetal and maternal risks associated with intrauterine transfusion procedures. Am. J. Obstet. Gynecol. 123:251.PubMedGoogle Scholar
  28. Umansky, I., and Frigoletto, F. D., 1976, Current Uses of Rho Immune Globulin and Detection of Antibodies, ACOG Technical Bulletin No. 35, January. Google Scholar
  29. Weinstein, L., 1976, Irregular antibodies causing hemolytic disease of the newborn. Obstet. Gynecol. Surv. 31:581.PubMedCrossRefGoogle Scholar
  30. Woodrow, J. C., 1965, Prevention of Rh haemolytic disease: A third report, Br. Med. J. 1:279.PubMedCrossRefGoogle Scholar
  31. World Health Organization Technical Report Series, No. 468, 1971, Prevention of Rh Sensitization. Google Scholar

Copyright information

© Aubrey Milunsky 1979

Authors and Affiliations

  • Fredric D. FrigolettoJr.
    • 1
    • 2
  • Irving Umansky
    • 3
    • 4
    • 5
    • 6
  1. 1.Department of ObstetricsBoston Hospital for WomenUSA
  2. 2.Department of Obstetrics-GynecologyHarvard Medical SchoolBostonUSA
  3. 3.Department of PediatricsHarvard Medical SchoolUSA
  4. 4.Blood Grouping LaboratoryCenter for Blood ResearchUSA
  5. 5.Department of MedicineChildren’s Hospital Medical CenterUSA
  6. 6.Department of HematologyBoston Hospital for WomenBostonUSA

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