Effect of Opiates on Neuroendocrine Function Testosterone and Pituitary Gonadotropins

  • Steven M. Mirin
  • Roger E. Meyer
  • James Ellingboe
  • Jack H. Mendelson


Among chronic opiate users, disturbances in sexual function are now commonly recognized clinical phenomena. In males, diminished libido, impotence, and delayed ejaculation have been described,(1) while amenorrhea and decreased fertility have been reported among female users of opiate drugs.(2) These observations have led to investigations of the effects of opiates on the pituitary gonadotropins, luteinizing hormone (LH), and follicle-stimulating hormone (FSH), and on the primary secretions of the end organs they influence (i.e., testosterone and estrogens). To date, most of these studies have utilized animal models. More recently some investigators have turned their attention to the effects of opiates in man.


Luteinizing Hormone Plasma Testosterone Luteinizing Hormone Level Plasma Testosterone Level Neuroendocrine Function 
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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • Steven M. Mirin
  • Roger E. Meyer
  • James Ellingboe
  • Jack H. Mendelson

There are no affiliations available

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