• Roger E. Meyer
  • Steven M. Mirin


As described at the outset, this work has had two general goals: (1) to define the multivariate nature of opioid reinforcement through an interdisciplinary study of the effects of unblocked and blocked heroin consumption upon subjective mood, gross behavior, cardiorespiratory physiology, operant work output for heroin, catecholamine metabolism, and endocrine homeostasis; and (2) to assess the effects of narcotic antagonists upon heroin self-administration in a research ward setting and at follow-up in the community in order to derive a possible model for the use of narcotic-blocking drugs in the rehabilitation of chronic heroin addicts. Because the work has been exploratory (albeit in an established context of earlier theory and some experimental work), it should serve to generate some questions for additional study. To some extent our findings may also help to clarify aspects of extant treatment modalities (e.g., methadone maintenance, residential therapeutic communities, civil commitment, and proposals for heroin maintenance), as well as other behavioral and substance abuse disorders (alcoholism, obesity, and smoking).


Discriminative Stimulus Methadone Maintenance Heroin Addict Heroin Addiction Opiate Addiction 
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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • Roger E. Meyer
  • Steven M. Mirin

There are no affiliations available

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