Biomaterials pp 131-146 | Cite as

Tissue Response to Implants

  • Joon Bu Park


To implant a material the tissue must be injured first. The injured or diseased tissues should be removed to some extent in the process of implantation. The success of the entire operation depends on the kind and degree of tissue response to implants during the healing process. The tissue response to injury may vary widely according to the site, species, contamination, etc. However, the inflammation and the cellular response to the wound for both intentional and accidental injuries are the same regardless of the sites.


Bone Cement Tissue Reaction Tissue Response Injured Site Spongy Bone 
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Further Reading

  1. C. O. Bechtol, A. B. Ferguson, and P. G. Laing, Metals and Engineering in Bone and Joint Surgery, Ballière, Tindall, and Cox, London, 1959.Google Scholar
  2. G. H. Bourne (ed.), The Biochemistry and Physiology of Bone, vol. III, chapter 10, 2nd edition, Academic Press, New York, 1971.Google Scholar
  3. J. Charnley, Acrylic Cement in Orthopaedic Surgery, Churchill Livingstone, Edinburgh, 1970.Google Scholar
  4. T. Gillman, “On Some Aspects of Collagen Formation in Localized Repair and in Diffuse Fibrotic Reactions to Injury,” in Treatise on Collagen, ed. B. S. Gould, vol. 2B, chapter 4, Academic Press, New York, 1968.Google Scholar
  5. L. L. Hench and E. C. Ethridge, “Biomaterials—The Interfacial Problem,” Adv. Biomed. Eng., 5, 35, 1975.Google Scholar
  6. S. F. Hulbert, S. N. Levine, and D. D. Moyle, Prosthesis and Tissue: The Interface Problem, J. Wiley and Sons, New York, 1974.Google Scholar
  7. S. N. Levine (ed.), “Materials in Biomedical Engineering,” Ann. N.Y. Acad. Sci., 146, 1968.Google Scholar
  8. H. I. Maibach and D. T. Rovee (eds.), Epidermal Wound Healing, Year Book Medical Publishers, Chicago, 1972.Google Scholar
  9. E. E. Peacock, Jr., and W. Van Winkle, Jr., Surgery and Biology of Wound Repair, chapters 1, 5, 6, and 11, W. B. Saunders Co., Philadelphia, 1970.Google Scholar
  10. R. Ross, “Wound Healing,” Sci. Am., 220, 40, 1969.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Joon Bu Park
    • 1
  1. 1.Clemson UniversityClemsonUSA

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