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The Structure and Function of Follicle-Stimulating Hormone

  • B. B. Saxena
  • P. Rathnam
Part of the Biochemical Endocrinology book series (BIOEND)

Abstract

Smith demonstrated in 1926 that hypophysectomy in rats resulted in the atrophy of the gonads. The occurrence of gonadotropic hormone activity in human urine led Aschheim and Zondek (1928) to indicate that the anterior pituitary gland might be the source of gonadotropins. Between 1928 and 1932, Smith and Engle (1927a-c), Collip et al. (1933), and Fevold et al. (1931) extended studies on pituitary gonadotropins in rats, mice, and sheep, and on human pregnancy urine. Lack of complete separation of follicle-stimulating hormone (FSH, follitropin) and luteinizing hormone (LH) suggested that one gonadotropin may exist with dual activity. The development of the human chorionic gonadotropin (hCG) augmentation assay for FSH (Steelman and Pohley, 1953) and the ovarian ascorbic acid depletion test for LH (Parlow, 1961) further accelerated the purification of FSH from LH. The development of more refined techniques for the separation of proteins and mostly the collection of a large number of glands by the National Pituitary Agency in the United States led to the isolation of human FSH (hFSH) in quantities sufficient for structure-function studies.

Keywords

Luteinizing Hormone Sialic Acid Pituitary Gland Corpus Luteum Seminiferous Tubule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used in this chapter

b, e, h, o, p

letter prefixes denoting, respectively, bovine, equine, human, ovine, and porcine hormones

CD

circular dichroism

FSH

follicle stimulating hormone (follitropin)

hCG

human chorionic gonadotropin

hMG

human menopausal gonadotropin

LH

luteinizing hormone

TSH

thyroid-stimulating hormone

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • B. B. Saxena
    • 1
  • P. Rathnam
    • 1
  1. 1.Cornell University Medical CollegeNew YorkUSA

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