Serum-Factor- and Prolactin-Induced Stimulation of DNA Synthesis by Nuclei Externalized from Mammary Tissue
A very intriguing but poorly understood event in cell biology is the transition from the G1 to the S phase of the cell cycle. It is this event that marks the change from a nonproliferative to a proliferative state. Cell-fusion studies (Rao and Johnson, 1970; Graves, 1972; Rao et al., 1977) suggest that the transition is under positive, rather than negative, control exerted by certain cytoplasmic factors. A variety of exogenous agents, including serum protein factors and hormones, can stimulate cell proliferation in vitro, but the molecular mechanisms have not been delineated.
KeywordsHorse Serum Native Insulin Mammary Nucleus Relative Incorporation Mammary Epithelial Cell Proliferation
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