Localization of Human Chorionic Gonadotropin in Lysosomes of Ovine Luteal Cells

  • T. T. Chen
  • M. C. McClellan
  • M. A. Diekman
  • J. H. AbelJr.
  • G. D. Niswender
Part of the Biochemical Endocrinology book series (BIOEND)


The first event in most current models regarding the hypothetical mechanism of gonadotropic hormone action is believed to involve binding to specific receptors located on the plasma membrane of target cells (Catt and Dufau, 1976; Cuatrecasas et al, 1975; Helmreich, 1976; Roth, 1973; Ryan and Lee, 1976). This binding initiates a series of acute biochemical responses, including activation of adenylate cyclase (Jungmann and Russell, 1977; Marsh, 1976), calcium-exchange mechanisms (Rasmussen and Goodman, 1975), and steroid secretion, probably as a consequence of the activation or synthesis of certain enzymes or functional proteins or both (Hermier et al, 1971; Abel et al, 1976). The interaction of hormone with receptors can also result in a number of sustained intracellular responses such as induction of synthesis of RNA and protein (Jungmann and Russell, 1977; Marsh, 1976). The signals that initiate all these regulatory events are believed to originate at the plasma membrane; however, evidence has been provided recently that protein hormones may also be capable of entering target cells and stimulating directly a variety of intracellular components (Braendle et al, 1973; Danzo et al, 1972; De Krester et al, 1971; Midgley and Beals, 1971; Petrusz and Uhlarik, 1973; Rajaniemi and Vanha-Perttula, 1972; Rao, Ch. V., et al.=, 1971; Sterling et al, 1977; Szego, 1975).


Luteinizing Hormone Adenylate Cyclase Corpus Luteum Germinal Vesicle Luteal Cell 


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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • T. T. Chen
    • 1
  • M. C. McClellan
    • 1
  • M. A. Diekman
    • 1
  • J. H. AbelJr.
    • 1
  • G. D. Niswender
    • 1
  1. 1.Department of Physiology and BiophysicsColorado State UniversityFort CollinsUSA

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