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Leydig-Cell Responsiveness to LH-hCG Stimulation: Mechanisms of hCG- and Steroid-Induced Refractoriness

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Structure and Function of the Gonadotropins

Part of the book series: Biochemical Endocrinology ((BIOEND))

Abstract

Since the discovery of polypeptide hormone receptors, sensitivity or refractoriness of a given cell to hormonal stimulation has been known to be related to the presence of the hormone receptor (Roth, 1973). The appearance of receptors and cell responsiveness has also been related to cell differentiation and maturation (Engel et al.,1973; Engel and Frowein, 1974). In recent years, it has been demonstrated that cell responsiveness may also vary according to preexposure of the target cells to the hormone (Tata, 1975; Raff, 1976; Kolata, 1977; Tell et al., 1978).

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Authors and Affiliations

  1. Unité de Recherches sur le Contrôle Hormonal des Activités Cellulaires, INSERM-U.162. Hôital Debrousse, Lyon, Cedex 1, 69322, France

    F. Haour & J. M. Saez

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  1. F. Haour
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  2. J. M. Saez
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Editors and Affiliations

  1. The International Society for Biochemical Endocrinology, Roselea House, 04615, Blue Hill Falls, Maine, USA

    Kenneth W. McKerns M.Sc., Ph.D. (President) (President)

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© 1978 Plenum Press, New York

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Haour, F., Saez, J.M. (1978). Leydig-Cell Responsiveness to LH-hCG Stimulation: Mechanisms of hCG- and Steroid-Induced Refractoriness. In: McKerns, K.W. (eds) Structure and Function of the Gonadotropins. Biochemical Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3414-9_21

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  • DOI: https://doi.org/10.1007/978-1-4684-3414-9_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3416-3

  • Online ISBN: 978-1-4684-3414-9

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