Timing and Sites of Testicular Effects of FSH in Vivo

  • A. G. Davies
  • N. R. Lawrence
Part of the Biochemical Endocrinology book series (BIOEND)


The earliest studies, in the laboratories of Smith and Greep in the 1930s, on the effects of gonadotropin preparations on the testis suggested that follicle-stimulating hormone (FSH) had a clear-cut role as the main hormone controlling gametogenesis. Subsequent work on the actions of gonadotropins and androgens on the testis has made it more difficult to be sure what the physiological role of FSH is in the male. A major difficulty in investigating the action of FSH has been the purification of the hormone so that one can be sure that the effects of an FSH preparation are not, at least in part, due to contaminating luteinizing hormone (LH). However, FSH, it is clear, has important actions on the immature testis that are not demonstrable in the normal adult animal. It is thus important to consider the effects of FSH separately before and after puberty.


Luteinizing Hormone Sertoli Cell Primary Spermatocyte Germinal Cell Seminiferous Epithelium 


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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • A. G. Davies
    • 1
  • N. R. Lawrence
    • 1
  1. 1.Department of PhysiologyMedical SchoolBirminghamEngland

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