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The Biosynthesis of Chorionic Gonadotropin and Placental Lactogen in First- and Third-Trimester Human Placenta

  • Irving Boime
  • Thomas Landefeld
  • Susan McQueen
  • Diana McWilliams
Part of the Biochemical Endocrinology book series (BIOEND)

Abstract

One of the important functions of the human placenta is its role in the formation of peptide hormones during pregnancy. The major protein hormones elaborated by the trophoblast are human chorionic gonadotropin (hCG) and human placental lactogen (hPL). The concentrations of these hormones in maternal serum during gestation are quite different. Whereas hCG peaks in the first trimester, hPL reaches maximal levels near term. Since it seems, then, that these two hormones differ in the way their synthesis is correlated with the course of pregnancy, it is apparent that the factors controlling their synthesis are also quite different. Thus, the placenta represents a convenient and unique tissue for studying control of human hormonal genes under the influence of a variety of physiological stimuli.

Keywords

Human Chorionic Gonadotropin Term Placenta Placental Lactogen Human Placental Lactogen Ectopic Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used in this chapter

cDNA

complementary DNA

hCG

human chorionic gonadotropin

hPL

human placental lactogen (also human chorionic somatomammotropin)

mRNA

messenger RNA

S-30, S-100

30,000g and 100,000g supernatants

SDS

sodium dodecyl sulfate

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Irving Boime
    • 1
  • Thomas Landefeld
    • 1
  • Susan McQueen
    • 1
  • Diana McWilliams
    • 1
  1. 1.Departments of Obstetrics and GynecologyWashington University School of MedicineSt. LouisUSA

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