The Biosynthesis of Chorionic Gonadotropin and Placental Lactogen in First- and Third-Trimester Human Placenta
One of the important functions of the human placenta is its role in the formation of peptide hormones during pregnancy. The major protein hormones elaborated by the trophoblast are human chorionic gonadotropin (hCG) and human placental lactogen (hPL). The concentrations of these hormones in maternal serum during gestation are quite different. Whereas hCG peaks in the first trimester, hPL reaches maximal levels near term. Since it seems, then, that these two hormones differ in the way their synthesis is correlated with the course of pregnancy, it is apparent that the factors controlling their synthesis are also quite different. Thus, the placenta represents a convenient and unique tissue for studying control of human hormonal genes under the influence of a variety of physiological stimuli.
KeywordsHuman Chorionic Gonadotropin Term Placenta Placental Lactogen Human Placental Lactogen Ectopic Tumor
Abbreviations used in this chapter
human chorionic gonadotropin
human placental lactogen (also human chorionic somatomammotropin)
- S-30, S-100
30,000g and 100,000g supernatants
sodium dodecyl sulfate
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