Peptide and Neurotransmitter Receptors in the Brain: Regulation by Ions and Guanyl Nucleotides
In recent years attention has focused on the localization of traditional peptide hormones in the brain. In several cases peptides, thought to be confined to the gastrointestinal tract, and associated glands and the pituitary, were reported to occur in the brain. Whether or not all gut peptide hormones exist in the brain as well is by no means clear. Interestingly, peptides first discovered in the brain, such as substance P and enkephalin, have subsequently been shown to occur also in the intestinal tract. Because of their localization in specific neuronal pathways, these peptides have been suggested as neurotransmitters. One way in which the brain peptides resemble conventional neurotransmitters lies in the properties of their receptor sites as defined in biochemical studies.
KeywordsDopamine Receptor Adenylate Cyclase Divalent Cation Neurotransmitter Receptor Glycine Receptor
Unable to display preview. Download preview PDF.
- 1.BLUME, A.J., Life Sci., in press, 1978.Google Scholar
- 7.MULLER, W.E. and S.H. SNYDER. Brain Res., in press, 1978.Google Scholar
- 8.PASTERNAK, G.W., H.A. WILSON and S.H. SNYDER. Mol. Pharmacol., 11:478–484, 1975.Google Scholar
- 9.PASTERNAK, G.W., A.M. SNOWMAN and S.H. SNYDER. Mol. Pharmacol., 11:735–744.Google Scholar
- 1.O. PEROUTKA, S.J., D.A. GREENBERG, D.C. U’prichard and S.H. Snyder. Mol. Pharmacol., in press, 1978.Google Scholar
- 11.PERT, C.B. and S.H. SNYDER. Mol. Pharmacol., 10:868–879, 1974.Google Scholar
- 13.SHARMA, S.K., M. NIRENBERG and W.A. KLEE. Proc. Natl. Acad. Sci., USA, 72:590–594.Google Scholar
- 14.SIMANTOV, R., A.M. SNOWMAN and S.H. SNYDER. Mol. Pharmacol., 14:977–986.Google Scholar
- 15.U’PRICHARD, D.C., D.A. BYLUND and S.H. SNYDER. J. Biol. Chem., in press, 1978.Google Scholar
- 17.U’PRICHARD, D.C. and S.H. SNYDER. J. Biol. Chem., in press, 1978.Google Scholar
- 18..YOUNG, A.B. and S.H. SNYDER. Proc. Natl. Acad. Sci., USA, 21:4002–4005.Google Scholar