The Role of GTP in the Coupling of Hormone Receptors and Adenylate Cyclase

  • M. Rodbell
  • W. Schlegel
Part of the Published Nobel Symposia book series (NOFS, volume 42)


The adenylate cyclase system is one of the most important biological communication systems known. Through this system, a variety of extracellular agents, including hormones and neuro-transmitting agents, regulate the production of the intracellular “messenger,” cyclic AMP, that profoundly affects the metabolism, growth, and differentiation of cells responding to these agents. Although it is generally agreed that the receptors for the extracellular agents and the enzyme that catalyzes the formation of cyclic AMP from ATP are separate molecules, not understood is the nature of the transduction process whereby binding of the hormones leads to changes in the activity of the enzyme.


Hormone Receptor Enzyme System Adenylate Cyclase Target Size Adenylate Cyclase Activity 
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • M. Rodbell
    • 1
  • W. Schlegel
    • 1
  1. 1.National Institutes of HealthBethesdaUSA

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