Activation of Release and Mechanism of Release of Neurohypophyseal Hormones

  • Niels A. Thorn
  • James T. Russell
  • Christian Torp-Pedersen
  • Marek Treiman
Part of the Published Nobel Symposia book series (NOFS, volume 42)


Mechanism of Activation of the “Classical” Oxytocinergic and Vasopressinergic Neurons in the Hypothalamus These neurons were some of the first to be shown to secrete hormones. They have their perikaryal region in the nucleus supra-opticus and paraventricularis and end in the neurohypophysis (some neurons or branches go to the median eminence). They release their hormones to the blood. It has been shown that they have recurrent collaterals (Kandel, 1964; Dreifuss and Kelly, 1972; Negoro and Holland/ 1972). Thus a transmitter function must also be considered for them. Recently neurons with the same hormone and/or binding protein have been demonstrated in other parts of the central nervous system, e.g. the spinal cord (Buijs et al., 1978; Sofroniew and Weindl, 1978; Summy-Long et al., 1978), but it has not been proved that hormone is released from these neurons. It may be mentioned that several other functions for vasopressin than the antidiuretic have been suggested, among them a role in memory and behaviour (deWied and Gispen, 1977; deWied, this volume). The origin of vasopressin responsible for such effects is not known.


Median Eminence Actomyosin ATPase Antidiuretic Effect NEUROHYPOPHYSEAL Hormone Neurosecretory Neuron 
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Niels A. Thorn
    • 1
  • James T. Russell
    • 1
  • Christian Torp-Pedersen
    • 1
  • Marek Treiman
    • 1
  1. 1.Institute of Medical Physiology CUniversity of CopenhagenCopenhagenDenmark

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