Discussion of Clinical Neuroendocrinology Section

  • Seymour Reichlin
Part of the Published Nobel Symposia book series (NOFS, volume 42)


The three papers by Drs. Besser, Yen and Müller are elegant examples of current work in clinical neuroendocrinology. They illustrate the powerful insights and tools that basic research has given to the clinical investigator, outline the scope of the major questions in pituitary regulation that are still unresolved, and anticipate some of the clinical benefits that have followed elucidation of the mechanisms of hypothalamic-pituitary regulation. Dr. Besser ascribes the beginnings of clinical neuroendocrinology to the introduction of synthetic hypothalamic releasing hormones and of dopamine agonists into clinical medicine. To be sure, these events must be considered to be a watershed in development of clinical neuroendocrinology for they mark the introduction of specific pharmacological tools into diagnosis and treatment, but the origins of clinical neuroendocrinology reach back much further. Perhaps these origins can be found in the writings of Vesalius(1543) who described the drainage of cerebrospinal fluid into the nose, hence the term pituitary (mucous, pituita, Gr.) or even earlier, in the writings of Aristotle, (384–322, B.C.), a doctor’s son who described pseudocyesis and the effects of castration on sex drive in animals and in man.


Growth Hormone Median Eminence Prolactin Secretion Prolactin Release Anterior Pituitary Function 
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Seymour Reichlin
    • 1
  1. 1.Tufts University School of MedicineBostonUSA

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