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Hypothalamic Hormones Regulating Pituitary (and Other) Functions: Their Physiology and Biochemistry as Well as Recent Studies with Their Synthetic Analogues

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Central Regulation of the Endocrine System

Abstract

It is well established now that the hypothalamic releasing and inhibitory hormones produced in the neuronal cell bodies regulate the secretory activity of the anterior pituitary gland. The discovery of several of these hormones and their isolation, structural identification and synthesis furnished the evidence for the theory of neurohumoral control of the pituitary gland put forward by Harris (1) and others.

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References

  1. Green, J.D. and G.W. Harris. J. Endocrinol. 5: 136–146, 1947.

    Article  PubMed  CAS  Google Scholar 

  2. Kastin, A.J., L.H. Miller, C.A. Sandman, A.V. Schally and N.P. Plotnikoff. In: Essays of Neurochemistry and Neuropharmacology, Vol. 1, edited by M.B.H. Youdim, W. Lovenberg, D.F. Sharman and J.R. Lagnado. London:Wiley, 1977 pp. 139–176.

    Google Scholar 

  3. Hokfelt, T., S. Efendic, C. Hellerstrom, C. Johansson, R. Luft and A. Arimura. Acta Endocrinol. 80 (Suppl. 200); 5–41, 1975.

    Google Scholar 

  4. Schally, A.V., D.H. Coy and C.A. Meyers. Ann. Rev. Biochem. 47; 89–128, 1978.

    Article  PubMed  CAS  Google Scholar 

  5. Schally, A.V., D.H. Coy, C.A. Meyers and A.J. Kastin. In: Hormonal Proteins and Peptides, Vol. 4, edited by C.H. Li. In Press. 1978.

    Google Scholar 

  6. Sétiló, G., B. Flerko, A. Arimura and A.V. Schally. Int. Rev. Cytol. 55: In Press. 1977.

    Google Scholar 

  7. Cooper, D.M.F., D. Synetos, R.B. Christie and D. Schulster. J. Endocrinol. 71; 171–172, 1976.

    Article  PubMed  CAS  Google Scholar 

  8. Jones, M.T., B. Gillham and E.W. Hillhouse. Fed. Proc. 36: 2104–2109, 1977.

    PubMed  CAS  Google Scholar 

  9. Schally, A.V., R.N. Andersen, H.S. Lipscomb, J.M. Long and R. Guillemin. Nature 188: 1192–1193, 1960.

    Article  CAS  Google Scholar 

  10. Schally, A.V., T.W. Redding, K. Chihara, W.Y. Huang, R.C.C. Chang, W.H. Carter, D.H. Coy and M. Saffran. The Endocrine Society, Submitted. Abstract, 1978.

    Google Scholar 

  11. Schally, A.V., W.Y. Huang, T.W. Redding, A. Arimura, D.H. Coy, K. Chihara, R.C.C. Chang, V. Raymond and F. Labrie. Submitted.

    Google Scholar 

  12. Schally, A.V., A. Arimura and A.J. Kastin. Science 179: 341–350, 1973.

    Article  PubMed  CAS  Google Scholar 

  13. Vale, W., C. Rivier and M. Brown. Ann. Rev. Physiol. 39: 473–527, 1977.

    Article  CAS  Google Scholar 

  14. Jacobs, L., P. Snyder, J. Wilber, R. Utiger and W.J. Daughaday. J. Clin. Endocrinol. Metab. 33: 996–998, 1971.

    Article  PubMed  CAS  Google Scholar 

  15. Tashijan, A., N. Barowski and D. Jensen. Biochem. Biophys. Res. Commun. 43: 516–523, 1971.

    Article  Google Scholar 

  16. Debeljuk, L., T.W. Redding, A. Arimura and A.V. Schally. Proc. Soc. Exp. Biol. Med. 142: 421–423, 1973.

    PubMed  CAS  Google Scholar 

  17. Bowers, C.Y., H. Friesen, P. Hwang, H. Guyda and K. Folkers. Biochem. Biophys. Res, Commun, 45: 1033–1041, 1971.

    Article  CAS  Google Scholar 

  18. Smith, J.R., T.R. laHann, R.M. Chestnut, M.A. Carino and A. Horita. Science 196: 660–661, 1977.

    Article  PubMed  CAS  Google Scholar 

  19. Martin, J.B., L.P. Renaud and P. Brazeau: Lancet 7931: 393–395, 1975.

    Article  Google Scholar 

  20. Jackson, I.M.D. and S. Reichlin. Endocrinology 95: 854–862, 1974.

    Article  PubMed  CAS  Google Scholar 

  21. Hokfelt, T., K. Fuxe, O. Johansson, S. Jeffcoate and N. White. Neurosci. Lett. 1: 133–139, 1975.

    Article  PubMed  CAS  Google Scholar 

  22. Bassiri, R.M. and R.D. Utiger. Endocrinology 90: 722–727, 1972.

    Article  PubMed  CAS  Google Scholar 

  23. Oliver, C., J.P. Charvet, J.L. Codaccioni, J. Vague and J.C. Porter. Lancet l: 873, 1974.

    Article  Google Scholar 

  24. Koch, Y., T. Baram and M. Fridkin. FEBS Lett. 63: 295–298, 1976.

    Article  PubMed  CAS  Google Scholar 

  25. Mitsuma, T., Y. Hirooka and N. Nihei. Acta Endocrinol. 83: 225–235, 1976.

    PubMed  CAS  Google Scholar 

  26. Reichlin, S., R. Saperstein, I.M.D. Jackson, A.E. Boyd, III and Y. Patel. Ann. Rev. Physiol. 38: 389–424, 1976.

    Article  CAS  Google Scholar 

  27. Hoffman, K. and C.Y. Bowers. J. Med. Chem. 13: 1099–1101, 1970.

    Article  Google Scholar 

  28. Rivier, J., W. Vale, M. Monahan, N. Ling and R. Burgus. J. Med. Chem. 15: 479–482, 1972.

    Article  PubMed  CAS  Google Scholar 

  29. Bowers, C.Y., A. Weil, J.K. Chang, H. Sievertsson, F. Enzmann and K. Folkers. Biochem. Biophys. Res. Commun. 40: 683–691, 1970.

    Article  PubMed  CAS  Google Scholar 

  30. Coy, D.H., Y. Hirotsu, T.W. Redding, E.J. Coy and A.V. Schally. J. Med. Chem. 18: 948–949, 1975.

    Article  PubMed  CAS  Google Scholar 

  31. Sowers, J.R., J.M. Hershman, H.E. Carlson, A.E. Pekary, A.W. Reed, M.G. Nair and C.M. Baugh. J. Clin. Endocrinol. Metab. 43: 856–860, 1976.

    Article  PubMed  CAS  Google Scholar 

  32. Sievertsson, H., S. Castensson, O. Lindgren and C.Y. Bowers. Acta Pharma. Suec. 11: 67–76, 1974.

    CAS  Google Scholar 

  33. Hirschmann, R.F. In: Proc. Int. Symp. Med. Chem. 5th, Paris, July 1976, edited by J. Matthieu, 1977, In Press.

    Google Scholar 

  34. Meites, J. and J.A. Clemens. In: Vitamins and Hormones, edited by R.S. Harris, P.L. Munson, E. Dizfalusy and J. Glover. New York:Academic, 1972, pp. 165–221.

    Google Scholar 

  35. Koch, Y., G. Goldhaber, I. Fireman, U. Zor, J. Shani and E. Tal. Endocrinology 100: 1476–1478, 1977.

    Article  PubMed  CAS  Google Scholar 

  36. Boyd, A.E., E. Spencer, I.M.D. Jackson and S. Reichlin. Endocrinology 99: 861–871, 1976.

    Article  PubMed  CAS  Google Scholar 

  37. Schally, A.V., A. Dupont, A. Arimura, J. Takahara, T.W. Redding, J. Clemens and C. Shaar. Acta Endocrinol. 82: 1–14, 1976.

    PubMed  CAS  Google Scholar 

  38. Schally, A.V., T.W. Redding, A. Arimura, A. Dupont and G.L. Linthicum. Endocrinology 100: 681–691, 1977.

    Article  PubMed  CAS  Google Scholar 

  39. MacLeod, R.M. Endocrinology 85: 916–923, 1969.

    Article  PubMed  CAS  Google Scholar 

  40. Takahara, J., A. Arimura and A.V. Schally. Endocrinology 95: 462–465, 1974.

    Article  PubMed  CAS  Google Scholar 

  41. MacLeod, R.M. Proc. Soc. Exp. Biol. Med. In Press, 1978.

    Google Scholar 

  42. Schally, A.V. and A.J. Kastin. Endocrinology 79: 768–772, 1966.

    Article  PubMed  CAS  Google Scholar 

  43. Nair, R.M.G., A.J. Kastin and A.V. Schally. Biochem. Biophys. Res. Commun. 43; 1376–1381, 1971.

    Article  PubMed  CAS  Google Scholar 

  44. Celis, M.E., S. Taleisnik and R. Walter. Proc. Natl. Acad. Sci. USA 68: 1428–1433, 1971.

    Article  PubMed  CAS  Google Scholar 

  45. Plotnikoff, N.P., A.J. Kastin, M.S. Anderson and A.V. Schally. Life Sci. 10: 1279–1283, 1971.

    Article  CAS  Google Scholar 

  46. Failli, A., K. Sestanj, H.U. Immer and M. Götz. Arzneim.-Forsch. Drug, Res. 27: 2286–2289, 1977.

    CAS  Google Scholar 

  47. Schally, A.V., A. Arimura, Y. Baba, R.M.G Nair, H. Matsuo, T.W. Redding, L. Debeljuk and W.F. White. Biochem. Biophys. Res. Commun. 43: 393–399, 1971.

    Article  PubMed  CAS  Google Scholar 

  48. Schally, A.V., R.M.G. Nair, T.W. Redding and A. Arimura. J. Biol. Chem. 246: 7230–7236, 1971.

    PubMed  CAS  Google Scholar 

  49. Matsuo, H., R.M.G. Nair, A. Arimura and A.V. Schally. Biochem. Biophys. Res. Commun. 43: 1134–1139, 1971.

    Article  Google Scholar 

  50. Baba, Y., H. Matsuo and A.V. Schally. Biochem. Biophys. Res.Commun. 44: 459–463, 1971.

    Article  PubMed  CAS  Google Scholar 

  51. Matsuo, H., A. Arimura, R.M.G. Nair and A.V. Schally. Biochem. Biophys. Res. Commun 45: 822–827, 1971.

    Article  PubMed  CAS  Google Scholar 

  52. Burgus, R., M. Butcher, M. Amoss, N. Ling, M. Monahan, J. Rivier, R. Fellows, R. Blackwell, W. Vale and R. Guillemin. Proc. Natl. Acad. Sci. USA 69: 278–282, 1972.

    Article  PubMed  CAS  Google Scholar 

  53. Schally, A.V., A.J. Kastin and D.H. Coy. Int. J. Fertil. 21: 1–30, 1976.

    PubMed  CAS  Google Scholar 

  54. Schally, A.V., A. Arimura, T.W. Redding, L. Debeljuk, W. Carter, A. Dupont and J.A. Vilchez-Martinez. Endocrinology 98: 380–391, 1976.

    Article  PubMed  CAS  Google Scholar 

  55. Cattanach, B.M., C.A. Iddon, H.M. Charlton, S.A. Chiappa and G. Fink. Nature Vol. 269: 338–340, 1977.

    Article  PubMed  CAS  Google Scholar 

  56. Kerdelhue, B., M. Jutisz, D. Gillessen and R.O Studer. Biochem. Biophys. Acta. 297: 540–548, 1973.

    Article  PubMed  CAS  Google Scholar 

  57. Koch, Y., P. Chobsieng, U. Zor, M. Fridkin and H.R. Lindner. Biochem. Biophys. Res. Commun. 55 : 623–629, 1973.

    Article  PubMed  CAS  Google Scholar 

  58. de la Cruz, A., A. Arimura, K.G. de la Cruz and A.V. Schally. Endocrinology 98: 490–497, 1976.

    Article  PubMed  Google Scholar 

  59. Arimura, A., N. Nishi and A.V. Schally. Proc. Soc. Exp. Biol. Med. 152: 71–75, 1976.

    PubMed  CAS  Google Scholar 

  60. Nishi, N., A. Arimura, K.G. de la Cruz and A.V. Schally. Endocrinology 98: 1024–1030, 1976.

    Article  PubMed  CAS  Google Scholar 

  61. Moss, R.L. Fed. Proc. 36: 1978–1983, 1977.

    PubMed  CAS  Google Scholar 

  62. Pedroza, E., J.A. Vilchez-Martinez, J. Fishback, A. Arimura and A.V. Schally. Biochem. Biophys. Res. Commun. 79: 234–238, 1977.

    Article  PubMed  CAS  Google Scholar 

  63. Fujino, M., S’. Kobayashi, M. Obayashi, T. Fukuda, S. Shinagawa, I. Yamakazi, R. Nakagami, W.F. White and R.H. Rippel. Biochem. Biophys. Res. Commun. 49: 698–705, 1972.

    Article  PubMed  CAS  Google Scholar 

  64. Coy, D.H., J.A. Vilchez-Martinez, E.J. Coy, N. Nishi, A. Arimura and A.V. Schally. Biochemistry 14: 1848–1851, 1975.

    Article  PubMed  CAS  Google Scholar 

  65. Monahan, M., M.S. Amoss, H.A. Anderson and W. Vale. Biochemitry 12; 4616–4620, 1973.

    Article  CAS  Google Scholar 

  66. Coy, D.H., J.A. Vilchez-Martinez, E.J. Coy and A.V. Schally. J. Med. Chetn. 19: 423–425, 1976.

    Article  CAS  Google Scholar 

  67. Vilchez-Martinez, J.A., D.H. Coy, A. Arimura, E.J. Coy, Y. Hirotsu and A.V. Schally. Biochem. Biophys. Res. Commun. 59: 1226–1232, 1974.

    Article  PubMed  CAS  Google Scholar 

  68. Sandow, J., W. von Rechenberg, W. König, M. Han, G. Jerabek and H. Fraser. In: Proc. Eur. Colloq. Hypothal. Horm., 2nd. Tubingen, July 26–28, 1976. Hamburg .’Verlag Chemie. In Press.

    Google Scholar 

  69. Reeves, J.J., G.K. Tarnavsky, S.R. Becker, D. Coy and A.V. Schally. Endocrinology 101: 540–547, 1977.

    Article  PubMed  CAS  Google Scholar 

  70. Banik, U.K. and M.L. Givner. Fertil. Steril. 27: 1078–1084, 1976.

    PubMed  CAS  Google Scholar 

  71. Beattie, C.W. and A. Corbin. Biol. Reprod. 16: 333–339, 1977.

    Article  PubMed  CAS  Google Scholar 

  72. Johnson, E.S., R.L. Gendrich and W.F. White. Fertil. Steril. 22: 853–860, 1976.

    Google Scholar 

  73. Auclair, C., P.A. Kelly, F. Labrie, D.H. Coy and A.V. Schally. Biochem. Biophys. Res. Commun. 76: 855–862, 1977.

    Article  PubMed  CAS  Google Scholar 

  74. Humphrey, R.R., B.L. Windsor, J.R. Reel and R.A. Edgren. Biol. Reprod. 16: 614–621, 1977.

    Article  PubMed  CAS  Google Scholar 

  75. Corbin, A., C.W. Beattie, J. Yardley and T.J. Foell. Endocrine Res. Commun. 3: 359–376, 1976.

    Article  CAS  Google Scholar 

  76. Arimura, A., E. Pedroza, J.A. Vilchez and A.V. Schally. Endocr. Res. Commun. In Press.

    Google Scholar 

  77. Rees, R.W.A., T.J. Foell, S. Chais and N. Grant. J. Med. Chem. 17: 1015–1019, 1974.

    Article  Google Scholar 

  78. de la Cruz, A., D.H. Coy, J.A. Vilchez-Martinez, A. Arimura and A.V. Schally. Science 191: 195–197, 1976.

    Article  PubMed  Google Scholar 

  79. Gonzalez-Barcena, D., A.J. Kastin, D.H. Coy, K. Nikolics and A.V. Schally. Lancet 2: 997–998, 1977.

    Article  PubMed  CAS  Google Scholar 

  80. Schally, A.V., S. Sawano, A. Arimura, J. Barrett, I. Wakabayashi and C.Y. Bowers. Endocrinology 84: 1493–1506, 1969.

    Article  PubMed  CAS  Google Scholar 

  81. Brazeau, P., W. Vale, R. Burgus, N. Ling, M. Butcher, J. Rivier and R. Guillemin. Science 179: 77–79, 1973.

    Article  PubMed  CAS  Google Scholar 

  82. Schally, A.V., A. Dupont, A. Arimura, T.W. Redding, N. Nishi, G.L. Linthicum and Schlesinger, D.H. Biochemistry 15: 509–514, 1976.

    Article  PubMed  CAS  Google Scholar 

  83. Rivier, J., P. Brazeau, W. Vale, N. Ling, R. Burgus, C. Gilon, J. Yardley and R. Guillemin. C.R. Acad. Sci. Paris 276: 2737–2740, 1973.

    CAS  Google Scholar 

  84. Coy, D.H., E.J. Coy, A. Arimura and A.V. Schally. Biochem. Biophys. Res. Commun. 54: 1267–1273, 1973.

    Article  PubMed  CAS  Google Scholar 

  85. Arimura, A., H. Sato, A. Dupont, N. Nishi and A.V. Schally. Science 189: 1007–1009, 1975.

    Article  PubMed  CAS  Google Scholar 

  86. Hall, R., G.M. Besser, A.V. Schally, D.H. Coy, D. Evered, D.J. Goldie, A.J. Kastin, A.S. McNeilly, C.H. Mortimer, C. Phenekos, W.M.G. Tunbridge and D. Weightman. Lancet 2: 581–584, 1973.

    Article  PubMed  CAS  Google Scholar 

  87. Besser, G.M., C.H. Mortimer, D. Carr, A.V. Schally, D.H. Coy, D. Evered, A.J. Kastin, W.M.G. Tunbridge, M.O. Thorner and R. Hall. Br. Med. J. 1: 352–355, 1974.

    Article  PubMed  CAS  Google Scholar 

  88. Arimura, A., W.D. Smith and A.V. Schally. Endocrinology 98: 540–543, 1976.

    Article  PubMed  CAS  Google Scholar 

  89. Arimura, A. and A.V. Schally. Endocrinology 98: 1069–1072, 1976.

    Article  PubMed  CAS  Google Scholar 

  90. Alberti, K.G.M.M., S.E. Christensen, J. Iverson, K. Seyer-Hansen, N.J. Christensen, Aa. Prange-Hansen, K. Lundbaek and H. Orshov. Lancet 2: 1299–1301, 1973.

    Article  PubMed  CAS  Google Scholar 

  91. Konturek, S.J., J. Tasler, W. Obtulowicz, D.H. Coy and A.V. Schally. J. Clin. Invest. 58: 1–6, 1976.

    Article  PubMed  CAS  Google Scholar 

  92. Mortimer, C.H., D. Carr, T. Lind, S.R. Bloom, C.N. Mallinson, A.V. Schally, W.M.G. Tunbridge, L. Yeoman, D.H. Coy, A.J. Kastin, G.M. Besser and R. Hall. Lancet 1: 697–701, 1974.

    Article  PubMed  CAS  Google Scholar 

  93. Bloom, S.R., C.H. Mortimer, M.O. Thorner, G.M. Besser, R. Hall, A. Gomez-Pan, V.M. Roy, R.C.G. Russell, D.H. Coy, A..J. Kastin and A.V. Schally, Lancet 2: 1106–1109, 1974.

    Article  PubMed  CAS  Google Scholar 

  94. Besser, G.M. and G.H. Mortimer. In: Frontiers in Endocrinology, edited by L. Martini and W.F. Ganong. New York:Raven, 1976, pp. 227–254.

    Google Scholar 

  95. Plotnikoff, N.P., A.J. Kastin and A.V. Schally. Pharmacol. Biochem. Behav. 2: 693–696, 1974.

    Article  PubMed  CAS  Google Scholar 

  96. Hall, R. and A. Gomez-Pan. In: Advances in Clinical Chemistry, Vol. 18, New York:Academic Press, 1976, pp. 173–212.

    Google Scholar 

  97. Rivier, J., M. Brown and W. Vale. Biochem. Biophys. Res. Commun. 65: 746–751, 1975.

    Article  PubMed  CAS  Google Scholar 

  98. Coy, D.H., E.J. Coy, C. Meyers, J. Drouin, L. Ferland, A. Gomez-Pan and A.V. Schally. Endocrinology 98: 305A, 1976.

    Article  Google Scholar 

  99. Meyers, C.A., D.H. Coy, W.Y. Huang, A.V. Schally and T.W. Redding. Biochemistry: In Press, 1978.

    Google Scholar 

  100. Efendic, S., R. Luft and H. Sievertsson. FEBS Letters 58: 302–305, 1975.

    Article  PubMed  CAS  Google Scholar 

  101. Sarantakis, D., W.A. McKinley, I. Juanakais, D. Clark and N.H. Grant. Clin. Endocrinol. 5s: 275–278, 1976.

    Article  Google Scholar 

  102. Meyers, C., A. Arimura, A. Gordin, R. Fernandez-Durango, D.H. Coy, A.V. Schally, J. Drouin, L. Ferland, M. Beaulieu and F. Labrie. Biochem. Biophys. Res. Commun. 74: 630–636, 1977.

    Article  PubMed  CAS  Google Scholar 

  103. Gordin, A., C. Meyers, A. Arimura, D.H. Coy and A.V. Schally. Acta Endocrinol. 86: 833–841, 1977.

    PubMed  CAS  Google Scholar 

  104. Brown, G.M., G.R. Van Loon, B.C.W. Hummel, L.J. Grota, A. Arimura and A.V. Schally. J. Clin. Endocr. Metab. 44: 784–790, 1977.

    Article  PubMed  CAS  Google Scholar 

  105. Veber, D.F., R.G. Strachan, S.J. Bergstand, F.W. Holly, C.T. Homnick, R. Hirschmann, M.A. Torchinana and R. Saperstein. J. Amer. Chem. Soc. 98; 2367–2369, 1976.

    Article  CAS  Google Scholar 

  106. Sarantakis, D., J. Teichman, E.L. Lieng and R.L. Fenichel, Biochem. Biophys. Res. Commun. 73: 336–346, 1976.

    Article  PubMed  CAS  Google Scholar 

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Schally, A.V. et al. (1979). Hypothalamic Hormones Regulating Pituitary (and Other) Functions: Their Physiology and Biochemistry as Well as Recent Studies with Their Synthetic Analogues. In: Fuxe, K., Hökfelt, T., Luft, R. (eds) Central Regulation of the Endocrine System. Published Nobel Symposia, vol 42. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3396-8_3

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