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Neurotransmitter Mechanisms in the Control of the Secretion of Hormones from the Anterior Pituitary

  • K. Fuxe
  • K. Andersson
  • A. Löfström
  • T. Hökfelt
  • L. Ferland
  • L. F. Agnati
  • M. Pérez de la Mora
  • R. Schwarcz
  • P. Eneroth
  • J.-Å. Gustafsson
  • P. Skett
Part of the Published Nobel Symposia book series (NOFS, volume 42)

Abstract

Over the last decades evidence has accumulated that hypothalamic catecholamines (CA) play an important role in the regulation of the secretion of hormones from the anterior pituitary gland (1–4). The mapping out of CA and peptidergic pathways such as LHRH pathways, TRH pathways and somatostatin containing pathways (5–7) has indicated that the noradrenaline (NA) and adrenaline (A) systems control the activity in the hypothalamic hormone containing systems via actions in the regions containing the LHRH-, TRH- and somato-statin-positive nerve cell bodies. The dopamine (DA) neurons, on the other hand, mainly seem to control the activity in the hypothalamic hormone containing pathways via an axo-axonic influence at the level of the external level of the median eminence (8,9). In the present paper the evidence will be summarized indicating that the various CA systems within the hypothalamus and the preoptic area can integrate hormonal and neuronal information, a property which makes them very suitable as controllers of the secretion of hypothalamic hormones from the anterior pituitary. The paper will mainly deal with the evidence that the hypothalamic DA pathways can inhibit the secretion of prolactin and LH and that noradrenergic pathways can facilitate the secretion of LH. Adrenaline pathways within the hypothalamus may instead both inhibit the secretion of prolactin and facilitate the secretion of LH.

Keywords

Anterior Pituitary Median Eminence Preoptic Area Medial Basal Hypothalamus Terminal System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • K. Fuxe
    • 1
  • K. Andersson
    • 1
  • A. Löfström
    • 1
  • T. Hökfelt
    • 1
  • L. Ferland
    • 1
  • L. F. Agnati
    • 1
  • M. Pérez de la Mora
    • 1
  • R. Schwarcz
    • 1
  • P. Eneroth
    • 2
  • J.-Å. Gustafsson
    • 3
  • P. Skett
    • 3
  1. 1.Dept. of HistologyKarolinska InstitutetStockholmSweden
  2. 2.Hormone Laboratory, Dept. of Obstetrics and GynecologyKarolinska HospitalStockholmSweden
  3. 3.Dept. of Medical ChemistryKarolinska InstitutetStockholmSweden

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