Skip to main content
SpringerLink
Log in

Pituitary Neuropeptides and Behavior

  • Chapter
Central Regulation of the Endocrine System

Part of the book series: Published Nobel Symposia ((NOFS,volume 42))

Abstract

The implication of ACTH, α-MSH and the neurohypophyseal hormones on adaptive behavior was first suggested by classical endocrine methods i.e. by the removal of the endocrine gland, in this case, the pituitary, the subsequent demonstration of a deficiency and finally the correction of the deficient function by treatment with hormones produced by the extirpated gland. Removal of the anterior lobe of the pituitary (De Wied, 1964) or the whole gland (Applezweig and Baudry, 1955; De Wied, 1969; Weiss et al., 1970) in rats impairs acquisition of shuttle box avoidance behavior. Removal of the posterior pituitary does not materially affect acquisition but interferes with the maintenance of shuttle box avoidance behavior (De Wied, 1965). These behavioral impairments could be corrected with ACTH but also with a-MSH and fragments of ACTH/MSH which are devoid of corticotropic effects, and with [Lys8]vasopressin (LVP) and [des-Gly9-Lys8] vasopressin (DG-LVP) the latter being virtually devoid of the classical endocrine effects of vasopressin (De Wied, 1969; Lande et al., 1971; Bohus et al., 1973). These results suggested that the behavioral effects of pituitary hormones are not mediated through an influence on their endocrine target tissues.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ader, R. & D. de Wied, Psychon. Sci. 29, 46–48, 1972.

    Google Scholar 

  • Allen, J.P., J.W. Kendall, R. McGilvra & C. Vancura, J. Clin. Endocr. 38, 586–593, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Applezweig, M.H. & F.D. Baudry, Psychol.Rep. 1, 417–420, 1955.

    Google Scholar 

  • Austen, B.M., D.G. Smyth, C. R. Snell, Nature 269, 619–621, 1977.

    Article  PubMed  CAS  Google Scholar 

  • Baldwin, D.M., Ch.K. Haun & Ch.H. Sawyer, Brain Res. 80, 291–301, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Bloom, F., D. Segal, N. Ling & R. Guillemin, Science 194, 630–632, 1976.

    Article  PubMed  CAS  Google Scholar 

  • Bohus, B., Horm. Behav. 8, 52–61, 1977.

    Article  PubMed  CAS  Google Scholar 

  • Bohus, B. & D. de Wied, Science 153, 318–320, 1966.

    Article  PubMed  CAS  Google Scholar 

  • Bohus, B., W.H. Gispen & D. de Wied, Neuroendocrin. 11, 137–143, 1973.

    Article  CAS  Google Scholar 

  • Bohus, B., H.H.L. Hendrickx, A.A. van Kolfschoten & T.G. Krediet, In: Sexual Behavior: Pharmacology and Biochemistry, Eds. M. Sandler and G.L. Gessa, Raven Press, N.Y., 269–275, 1975.

    Google Scholar 

  • Bohus, B., I. Urban, Tj.B. van Wimersma Greidanus & D. de Wied, Neuropharmacol., 17, 239–247, 1978.

    Article  CAS  Google Scholar 

  • Bradbury, A.F., D.G. Smyth, CR. Snell, N.J.M. Birdsall & E.C. Hulme, Nature 260, 793–795, 1976.

    Article  CAS  Google Scholar 

  • De Wied, D., Am. J. Physiol. 207, 255–259, 1964.

    Google Scholar 

  • De Wied, D., Int. J. Neuropharmacol. 4, 157–167, 1965.

    Article  Google Scholar 

  • De Wied, D., Proc. Soc. exp. Biol. 122, 28–32, 1966

    PubMed  Google Scholar 

  • De Wied, D., In: Frontiers in Neuroendocrinology, Eds. W.F. Ganong and L. Martini, Oxford University Press, London/New York, 97–140, 1969.

    Google Scholar 

  • De Wied, D., Nature 232, 58–60, 1971.

    Article  PubMed  Google Scholar 

  • De Wied, D., In: The Neurosciences, Third Study Program, Eds. F.O. Schmitt and F.G. Worden, MIT Press, Cambridge, 653–666, 1974

    Google Scholar 

  • De Wied, D., Life Sci. 19, 685–690, 1976,

    Article  PubMed  Google Scholar 

  • De Wied, D. & B. Bohus, Nature 212, 1484–1486, 1966.

    Article  PubMed  Google Scholar 

  • De Wied, D., A. Witter & H.M. Greven, Biochem. Pharmacol. 24, 1463–1468, 1975.

    Article  PubMed  Google Scholar 

  • De Wied, D., B. Bohus, J.M. van Ree & I. Urban, J. Pharmacol, and exp. Ther. 204, 570–580, 1978.

    Google Scholar 

  • Eberle, A. & R. Schwyzer, Helv. Chim. Acta, 58, 1528–1535, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Ferrari, W., G.L. Gessa & L. Vargiu, Ann. N.Y. Acad. Sci. 104, 330–345, 1963.

    Article  PubMed  CAS  Google Scholar 

  • Flexner, J.B. & L.B. Flexner, Proc. Nat. Acad. Sci (Wash.) 68, 2519–2521, 1971.

    Article  CAS  Google Scholar 

  • Flood, J.F., M.E. Jarvik, E.L. Bennett & A.E. Orme, The Neuropeptides; Pharmacol. Biochem. Behav., Vol. 5, suppl. 1, 41–51, 1976.

    Article  Google Scholar 

  • Gaillard, A.W.K. & A.F. Sanders, Psychopharmacol. (Berl.) 42, 201–208, 1975.

    Article  CAS  Google Scholar 

  • Garrud, P., J.A. Gray & D. de Wied, Physiol. Behav. 12, 109–119, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Gessa, G.L., M. Pisano, L. Vargiu, F. Crabai & W. Ferrari, Rev; Canad. Biol. 26, 229–236, 1967.

    PubMed  CAS  Google Scholar 

  • Gispen, W.H. & V.M. Wiegant, Neuroscience Letters 2, 159–164, 1976.

    Article  PubMed  CAS  Google Scholar 

  • Gispen, W.H., V.M. Wiegant, H.M. Greven & D. de Wied, Life Sci. 17, 645–652, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Gispen, W.H., J. Buitelaar, V.M. Wiegant, L. Terenius & D. de Wied, Europ. J. Pharmacol. 39, 393–397, 1976a.

    Article  CAS  Google Scholar 

  • Gispen, W.H., V.M. Wiegant, A.F. Bradbury, E.C. Hulme, D.G. Smyth,

    Google Scholar 

  • C.R. Snell & D. de Wied, Nature 264, 794–795, 1976b.

    Article  Google Scholar 

  • Gold, P.E. & R. van Buskirk, Behav. Biol. 16, 387–400, 1976.

    Article  PubMed  CAS  Google Scholar 

  • Gray, J.A. Nature, 229, 52–54, 1971.

    Article  PubMed  CAS  Google Scholar 

  • Greven, H.M. & D. de Wied, In: Drug Effects on Neuroendocrine Regulation, Progress in Brain Research 39, Eds. E. Zimmermann, W.H. Gispen, B.H. Marks & D. de Wied, Elsevier Publ. Comp. Amsterdam 429–422, 1973.

    Chapter  Google Scholar 

  • Greven, H.M. & D. de Wied, In: Melanocyte Stimulating Hormone: Control, Chemistry & Effects, Eds. F.J.H. Tilders, D.F. Swaab & Tj.B. van Wimersma Greidanus, Frontiers of Hormone Research Vol. 4, S. Karger, Basel, 140–152, 1977.

    Google Scholar 

  • Guth, S., S. Levine & J.P. Seward, Physiol. Behav. 7, 195–200, 1971.

    Article  PubMed  CAS  Google Scholar 

  • Hughes, J., T.W. Smith, H.W. Kosterlitz, L.A. Fothergill, B.A. Morgan & H.R. Morris, Nature 258, 577–579, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Isaacson, R.L., A.J. Dunn, H.D. Rees & B. Waldock, Physiol. Psychol. 4, 159–162, 1976.

    Google Scholar 

  • Izumi, K., J. Donaldson & A. Barbeau, Life Sci. 12, 203–210, 1973

    Article  CAS  Google Scholar 

  • Jacquet, Y.F. & N. Marks, Science 194, 632–634, 1976.

    Google Scholar 

  • Kastin, A.J., L.H. Miller, R. Nockton, C.A. Sandman, A.V. Schally & L.O. Stratton, In: Drug Effects on Neuroendocrine Regulation, Eds. E. Zimmermann, W.H. Gispen, B.H. Marks & D. de Wied, Progress in Brain Research, 39, 461–470, Elsevier Amsterdam, 1973.

    Chapter  Google Scholar 

  • Kastin, A.J., CA. Sandman, L.O. Stratton, A.V. Schally & L.H. Miller, In: Hormones, Homeostasis and the Brain, Progress in Brain Research 42, Eds. W.H. Gispen, Tj.B. van Wimerma Greidanus & D. de Wied, Elsevier, Amsterdam, 143–150, 1975.

    Google Scholar 

  • Krieger, D.T., A. Liotta & M.J. Brownstein, Proc. Natl. Acad. Sci. 74, 648–652, 1977a.

    Article  CAS  Google Scholar 

  • Krieger, D.T., A. Liotta & M.J. Brownstein, Brain Res. 128, 575–579, 1977b.

    Article  CAS  Google Scholar 

  • Lande, S., A. Witter & D. de Wied, J. Biol. Chem. 246, 2058–2062, 1971

    PubMed  CAS  Google Scholar 

  • Lande, S., J.B. Flexner & L.B. Flexner, Proc. Nat. Acad. Sci. 69, 558–560, 1972.

    Article  PubMed  CAS  Google Scholar 

  • Lande, S., D. de Wied & A. Witter, In: Drug Effects on Neuroendocrine Regulation, Eds. W. Zimmermann, W.H. Gispen, B.H. Marks & D. de Wied, Elsevier, Amsterdam, Progress in Brain Research 39, 421–427, 1973.

    Chapter  Google Scholar 

  • Legros, J.J., P. Gilot, X. Seron, J. Claessens, J. Adam, J.M. Moeglen, A. Audibert & P. Berchier, The Lancet, January 7, 41, 1978.

    Article  Google Scholar 

  • Leonard, B.E. Int. J. Neuropharmacol. 8, 427–435, 1969.

    Article  PubMed  CAS  Google Scholar 

  • Levine, S. & L.E. Jones, J. Comp. Physiol. Psychol. 59, 357–360, 1965

    Article  PubMed  CAS  Google Scholar 

  • Lissák, K. & B. Bohus (1972), Int. J. Psychobiology 2, 103–115, 1972.

    Google Scholar 

  • Marks, N. & F. Stern, Biochem. Biophys. Res. Commun. 61, 1458–1463, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Marks, N., L. Abrash & R. Walter, Proc. Soc. exp. Biol. (N.Y.) 142, 455–460, 1973.

    CAS  Google Scholar 

  • Mezey, E., M. Palkovits, E.R. de Kloet, J. Verhoef & D. de Wied, Life Sci. 22, 831–838, 1978.

    Article  PubMed  CAS  Google Scholar 

  • Oliver, C., R.S. Mical & J.C. Porter, Endocrinol. 101, 598–604, 1977.

    Article  CAS  Google Scholar 

  • Oliveros, J.C. M.K. Jandali, M. Timsit-Berthier, R. Remy, A. Benghezal, A. Audibert & J.M. Moeglen, The Lancet, January 7, 42, 1978.

    Article  Google Scholar 

  • Page, R.B., B.L. Munger & R.M. Bergland, Am. J. Anat. 146, 273–301, 1970.

    Article  Google Scholar 

  • Pliska, V., R. Barth & N.A. Thorn, Acta Endocr. 67, 1–11, 1971.

    PubMed  CAS  Google Scholar 

  • Pliska, V., N.A. Thorn & H. Vilhardt, Acta Endocr. 67, 12–22, 1971.

    PubMed  CAS  Google Scholar 

  • Rees, H.D., A.J. Dunn & P.M. Juvone, Life Sci. 18, 1333–1340, 1976.

    Article  PubMed  CAS  Google Scholar 

  • Rigter, H. & A. Popping, Psychopharmacol. 46, 255–261, 1976.

    Article  CAS  Google Scholar 

  • Rigter, H. & H. van Riezen, Physiol. Behav. 14, 563–566, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Rigter, H., H. van Riezen & D. de Wied, Physiol. Behav. 13, 381–388, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Rudman, D., J.W. Scott, A.E. DelRia, D.H. Houser & S. Sheen, Amer. J. Physiol. 226, 687–692, 1974.

    PubMed  CAS  Google Scholar 

  • Sandman, C.A., A.J. Kastin & A.V. Schally, Experientia (Basel) 25, 1001–1002, 1969.

    Article  CAS  Google Scholar 

  • Schulz, H., G.L. Kovács & G. Telegdy, In: Cellular & Molecular Bases of Neuroendocrine Processes, Ed. E. Endroczi, Akadémiai Kiadók, Budapest, 555–564, 1976.

    Google Scholar 

  • Segal, D.S., F. Bloom, N. Ling & R. Guillemin, Science, 198, 411–414, 1977.

    Article  PubMed  CAS  Google Scholar 

  • Szentagothai, J., B. Flerko, B. Mess & B. Halász, Akadémiai Kiadó, Budapest, 1968.

    Google Scholar 

  • Tanaka, M., D.H.G. Versteeg & D. de Wied, Neuroscience Letters 4, 321–325, 1977a.

    Article  CAS  Google Scholar 

  • Tanaka, M., E.R. de Kloet, D. de Wied & D.H.G. Versteeg, Life Sci. 20, 1799–1808, 1977b.

    Article  CAS  Google Scholar 

  • Terenius, L., J. Pharm. Pharmacol. 27, 450–452, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Terenius, L., Europ. J. Pharmacol. 38, 211–213, 1976.

    Article  CAS  Google Scholar 

  • Terenius, L., W.H. Gispen & D. de Wied, Europ. J. Pharmacol. 33, 395–399, 1975.

    Article  CAS  Google Scholar 

  • Török, B., Anat. Anz. 109, 622, 1960.

    Google Scholar 

  • Török, B., Acta Anat. (Basel) 59, 84–99, 1964.

    Article  Google Scholar 

  • Van Ree, J.M., B. Bohus, D.H.G. Versteeg & D. de Wied, Biochem. Pharmacol, in press, 1978.

    Google Scholar 

  • Van Wimersma Greidanus, Tj.B. J. Dogterom & D. de Wied, Life Sci. 16, 637–644, 1975.

    Google Scholar 

  • Verhoeven, W.M.A., H.M. van Praag, P.A. Botter, A. Sunier, J.M.van Ree & D. de Wied, The Lancet, May 13, 1046–1047, 1978.

    Article  Google Scholar 

  • Walter, R., E.C. Griffiths & K.C. Hooper, Brain Res. 60, 449–457, 1973

    Article  PubMed  CAS  Google Scholar 

  • Walter, R., P.L. Hoffmann, J.B. Flexner & L.B. Flexner, Proc. Nat. Acad. Sci (USA) 72, 4180–4184, 1975.

    Article  CAS  Google Scholar 

  • Walter, R., J.M. van Ree & D. de Wied, Proc. Nat. Acad. Sci, in press, 1978.

    Google Scholar 

  • Weiss, J.M., B.S. McEwen, M. Silva & M. Kalkut, Am. J. Physiol. 218, 864–868, 1970.

    PubMed  CAS  Google Scholar 

  • Wiegant, V.M. & W.H. Gispen, Behav. Biol. 19, 554–558, 1977.

    Article  PubMed  CAS  Google Scholar 

  • Winter, C.A. & L. Flataker, J. Pharmacol. exp. Ther. 101, 93, 1951.

    Google Scholar 

  • Witter, A., H.M. Greven & D. de Wied, J. Pharmacol. exp. Ther. 193, 853–860, 1975.

    PubMed  CAS  Google Scholar 

  • Zimmermann, E. & W.A. Krivoy, In: Drug Effects on Neuroendocrine Regulation, Progress in Brain Res. 39, Eds. E. Zimmermann, W.H. Gispen, B.H. Marks & D. de Wied, Elsevier, Amsterdam, 383–394, 1973.

    Chapter  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Rudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht, Vondellaan 6, Utrecht, Netherlands

    D. de Wied

Authors
  1. D. de Wied
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Karolinska Institute, Stockholm, Sweden

    Kjell Fuxe , Tomas Hökfelt  & Rolf Luft ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Plenum Press, New York

About this chapter

Cite this chapter

de Wied, D. (1979). Pituitary Neuropeptides and Behavior. In: Fuxe, K., Hökfelt, T., Luft, R. (eds) Central Regulation of the Endocrine System. Published Nobel Symposia, vol 42. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3396-8_21

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-3396-8_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3398-2

  • Online ISBN: 978-1-4684-3396-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation