Steroid Hormone Receptors in Brain and Pituitary
Steroid hormones act upon the brain and pituitary gland to regulate hormone secretion rates and to influence particular behaviors (see McEwen, 1976, for overview). Many of these actions appear to be the result of an interaction of steroids with specific intracellular receptor proteins which translocate hormone into the cell nuclear compartment to alter genomic activity (see McEwen et al, 1978, and Baulieu, this volume, for a discussion of this and alternative cellular mechanisms of steroid action). Intracellular steroid receptor proteins have been identified for five major classes of steroid hormones, estrogens, androgens, progestins, glucocorticoids, and mineralocorticoids, and have been extensively studied both with respect to their physical and chemical properties and their neuroanatomical distribution within the brain (see McEwen, 1976, 1978). In general, each receptor system binds preferentially the most active members of that particular class of steroid hormones and displays a distinctive regional distribution pattern in the CNS.
KeywordsEstrogen Receptor Steroid Hormone Receptor Preoptic Area Estrogen Effect Cyproterone Acetate
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