Effect of Peptides on Brain Monoamines and on Gross Behaviour
The discovery of a large number of endogenous peptides with possible neurotransmitter functions in various brain regions (see Hökfelt, This Symposium) raises the question as to the role of these neuropeptides in brain physiology as well as in neuropsychiatric disorders. The neuropeptides do not readily pass through the blood-brain barrier and thus it is doubtful to what extent systemic administration of the neuropeptides will help to elucidate their functions in the CNS. In the future we may expect that synthetic neuropeptide analogues capable of penetrating this barrier will become available. In fact, such development is already underway. Meanwhile we must resort to local application procedures. In the present investigation we have studied the effects of intracerebroventricular injections of several neuropeptides as well as of synthetic analogues. In view of the apparently close relationship between the neuropeptides and the monoamines (see Hökfelt, this Symposium) we have studied the effects of the neuropeptides on the synthesis and utilization of the brain monoamines. In addition, observations on gross behaviour and locomotor activity were recorded.
KeywordsCorpus Striatum Increase Locomotor Activity Brain Monoamine Limbic Forebrain Dopa Formation
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