Advertisement

Contrasting Principles of Synaptic Physiology: Peptidergic and Non-Peptidergic Neurons

  • Floyd E. Bloom
Part of the Published Nobel Symposia book series (NOFS, volume 42)

Abstract

A major unresolved theoretical issue in Neurobiology is the nature of the information encoded into chemical neurotransmitters. One aspect of that central issue is the question of whether the nervous system uses an exclusive set of chemical commands to regulate and respond to the endocrine system. Alternatively, the chemical signals of neurons and endocrine glands may simply be part of a general chemical vocabulary by which neurons communicate with cells.

Keywords

Locus Coeruleus Locus Coeruleus Neuron Simple Amino Acid Local Circuit Neuron Noradrenergic Fiber 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Aghajanian, G.K., J.M. Cedarbaum, and R.Y. Wang. Brain Res. 136: 570, 1977.PubMedCrossRefGoogle Scholar
  2. 2.
    Aghajanian, G.K. and R.Y. Wang. In: Psychopharmacologv: A. Generation of Progress., edited by M.A. Lipton, A. diMascio, K. Killam. New York: Raven Press, 1978, p. 171.Google Scholar
  3. 3.
    Barker, J.L. In: Peptides in Neurobiology, edited by H. Gamer. New York: Plenum Press, 1977, p.295.CrossRefGoogle Scholar
  4. 4.
    Barker, J.L. and T.G. Smith, Jr. Neurosci. Symp. 2:340. 1977.Google Scholar
  5. 5.
    Barker, J.L., J.H. Neale, T.G. Smith, Jr., and R.L. Macdonald. Science 199: 1451, 1978.PubMedCrossRefGoogle Scholar
  6. 6.
    Bennett, J.P., Jr. and S.H. Snyder. J.Biol.Chem. 251; 7423, 1976.PubMedGoogle Scholar
  7. 7.
    Bertaccini, G. Pharmacol. Rev. 28: 127, 1976.PubMedGoogle Scholar
  8. 8.
    Bloom, F.E. Brain Res. 62: 299, 1973.PubMedCrossRefGoogle Scholar
  9. 9.
    Bloom, F.E. Life Sci. 14: 1819, 1974a.PubMedCrossRefGoogle Scholar
  10. 10.
    Bloom, F.E. In: The Neuroseienees: Third Study Program, edited by F.O. Schmitt. Massachusetts: MIT Press, 1974b, p. 989.Google Scholar
  11. 11.
    Bloom, F.E. Rev. Physiol. Biochem. Pharmacol. 74: 1, 1975.PubMedGoogle Scholar
  12. 12.
    Bloom, F.E., J. Rossier, E.L.F. Battenberg, A. Bayon, E. French, S.J. Henriksen, G.R. Siggins, N. Ling, and R. Guillemin. In: Endorphins in Mental Health Research. edited by E. Usdin, 1978, in press.Google Scholar
  13. 13.
    Bloom, F.E. Biosystems 8: 179, 1977b.PubMedCrossRefGoogle Scholar
  14. 14.
    Bloom, F.E. In: Neurosciences—A Fourth Study Program. edited by F.O. Schmitt and F.G. Worden. Boston: MIT Press, 1978 (in press).Google Scholar
  15. 15.
    Brown, M., J. Rivier, and W. Vale. Abstr. Int. Soc. Psychoneuroendocrinology, 1977.Google Scholar
  16. 16.
    Brunelli, M., Castellucci, V. and E.R. Kandel. Science 194: 1178, 1976.PubMedCrossRefGoogle Scholar
  17. 17.
    Bunge, R., M. Johnson, CD. Ross. Science 199: 1409, 1978.PubMedCrossRefGoogle Scholar
  18. 18.
    Castellucci, V. and E.R. Kandel. Aplvsia. Science 194: 1176, 1976.Google Scholar
  19. 19.
    Daly, J. In: Cyclic Nucleotides in the Nervous. System, New York: Plenum Press, 1977.Google Scholar
  20. 20.
    Dismukes, K. Nature 269: 557, 1977.CrossRefGoogle Scholar
  21. 21.
    Dowling, J.E., B. Ehinger, and W.L. Hedden. Invest. Ophthalmol. 15: 916, 1975.Google Scholar
  22. 22.
    Enna, S.J. and Snyder, S.H. Brain Res. 115: 174, 1976.PubMedCrossRefGoogle Scholar
  23. 23.
    Florey, E. Fed. Proc. 26: 1164, 1967.PubMedGoogle Scholar
  24. 24.
    Foote, S., R. Freedman, and A.P. Oliver. Brain Res. 86: 229, 1975.PubMedCrossRefGoogle Scholar
  25. 25.
    Frederickson, R.C.A. Life Sci. 21: 23, 1977.PubMedCrossRefGoogle Scholar
  26. 26.
    Freedman, R., B.J. Hoffer, D.J. Woodward, and D. Puro. Exp. Neurol. 55: 269, 1977.PubMedCrossRefGoogle Scholar
  27. 27.
    Gahwiler, B.H. Nature 259: 483, 1976.PubMedCrossRefGoogle Scholar
  28. 28.
    Greengard, P. Science 199: 146, 1978PubMedCrossRefGoogle Scholar
  29. 29.
    Guyenet, P.G. and G.K. Aghajanian. Brain Res. 136: 178, 1977.PubMedCrossRefGoogle Scholar
  30. 30.
    Hoffer, B.J., G.R. Siggins, and F.E. Bloom. Science 166: 1418, 1969.PubMedCrossRefGoogle Scholar
  31. 31.
    Hoffer, B.J., G.R. Siggins, and F.E. Bloom. Brain Res. 25: 523, 1971.PubMedCrossRefGoogle Scholar
  32. 32.
    Hoffer, B.J., G.R. Siggins, A.P. Oliver, and F.E. Bloom. J. Pharmacol. Expt. Ther. 184: 553, 1973.Google Scholar
  33. 33.
    Hoffman, G.E., K.M. Knigge, J.A. Moynihan, V. Melnyk, and A. Arimura. Neuroscience 3: 219, 1978.PubMedCrossRefGoogle Scholar
  34. 34.
    Hokfelt, T., R. Elde, O. Johansson, A. Ljungdahl, A. Schutzberg, and K. Fuxe et al. In: Psvchopharmacoloqv—A Generation of Progress, edited by A. diMascio, M. Lipton and K. Killam. New York: Raven Press, 1977, in press.Google Scholar
  35. 35.
    Hokfelt, T., L.G. Elfvin, R. Elde, M. Schultzberg, M. Goldstein, and R. Luft. Proc. Nat. Acad. Sci. 74:1587. 1977.Google Scholar
  36. 36.
    Hokfelt, T., A. Ljungdahl, L. Terenius, R. Elde, and G. Nilsson. Proc. Nat. Acad. Sci. U.S.A. 74: 3081, 1977.CrossRefGoogle Scholar
  37. 37.
    Hokfelt, T., N. Halasz, A. Ljungdahl, O. Johansson, M. Goldstein, and D. Park. Neurosci. Lett. 1: 85, 1975.PubMedCrossRefGoogle Scholar
  38. 38.
    Hore, J., J. Meyer-Lohmann, and V.B. Brooks. Science 195: 584, 1977.PubMedCrossRefGoogle Scholar
  39. 39.
    Kahn, C.R. J. Cell Biol. 70: 261, 1976.PubMedCrossRefGoogle Scholar
  40. 40.
    Kandel, E.R. In: Cellular Basis of Behavior, edited by W.H. Freeman. San Francisco: W.H. Freeman, 1976.Google Scholar
  41. 41.
    Koda, L.Y., J.A. Schulman, and F.E. Bloom. Brain Res. 145: 140, 1978.CrossRefGoogle Scholar
  42. 42.
    Kosterlitz, H.W., J. Hughes, J.A.H. Lord, and A.A. Waterfield. Neurosci. Svmp. 2: 291, 1977.Google Scholar
  43. 43.
    Krnjevic, K. In: Handbook Psvchopharmacologv. edited by L.L. Iversen, S.D. Iversen, and S.H. Snyder. New York: Plenum, 1975, 6, 97.Google Scholar
  44. 44.
    Levitt, P. and R.Y. Moore. Brain Res., 1978 in press.Google Scholar
  45. 45.
    Libet, B., H. Kobayashi, and T. Tanaka. Nature 258: 155, 1975.PubMedCrossRefGoogle Scholar
  46. 46.
    Lindvall, O. and A.A. Bjorklund. Acta Physiol. Scand. Suppl. 412: 1, 1974.PubMedGoogle Scholar
  47. 47.
    Lindvall, O., A. Bjorklund, A. Nobin, and U. Stenevi. J. Comp. Neurol. 154: 317, 1974.PubMedCrossRefGoogle Scholar
  48. 48.
    Macdonald, R.L. and P.G. Nelson. Science 199: 1449, 1978.PubMedCrossRefGoogle Scholar
  49. 49.
    Macknight, A.D.C. and A. Leaf. Physiol. Rev. 57: 510, 1977.PubMedGoogle Scholar
  50. 50.
    Malvin, R.L., D. Mouw, and A.J. Vander. Science 197: 171, 1977.PubMedCrossRefGoogle Scholar
  51. 51.
    Moore, R.Y. and F.E. Bloom. Ann. Rev. Neurosci. 1: 129, 1978.PubMedCrossRefGoogle Scholar
  52. 52.
    Nathanson, J. Physiol. Rev. 57: 157, 1977.PubMedGoogle Scholar
  53. 53.
    Nicoli, R.A. Neurosci. Symp. 1: 99, 1976.Google Scholar
  54. 54.
    Nicoli, R.A. In: Psychopharmacologv—A Generation of Progress edited by M. Lipton, A. diMascio, K. Killam. New York: Raven Press, 1978, p. 103.Google Scholar
  55. 55.
    Pearse, A.G.E. Nature, 262: 92, 1976.CrossRefGoogle Scholar
  56. 56.
    Pearse, A.G.E. and T. Takor. Clin. Endocrin. Suppl. 5: 229, 1976.CrossRefGoogle Scholar
  57. 57.
    Phillips, M.I., D. Felix, W.E. Hoffman, and Ganten. Neurosci. Svmp. 2: 308, 1977.Google Scholar
  58. 58.
    Rakic, P. Neurosci. Res. Progr. Bull. 13: 293, 1975.Google Scholar
  59. 59.
    Rehfeld, J.F. Nature 271: 771–773, 1978.PubMedCrossRefGoogle Scholar
  60. 60.
    Renaud, L. J. Physiol. 264: 541, 1977.PubMedGoogle Scholar
  61. 61.
    Scharrer, B. J. Neuro-Vise. Rel. Suppl. IX: 1, 1969.Google Scholar
  62. 62.
    Schmitt, F.O., P. Dev, and B.H. Smith. Science 193: 114, 1976.PubMedCrossRefGoogle Scholar
  63. 63.
    Schulman, J.A. and F.F. Weight. Science 194: 1437, 1976.PubMedCrossRefGoogle Scholar
  64. 64.
    Segal, M. Exp. Brain Res. 29: 553–565, 1977.PubMedCrossRefGoogle Scholar
  65. 65.
    Segal, M. and F.E. Bloom. Brain Res. 72: 79, 1974a.PubMedCrossRefGoogle Scholar
  66. 66.
    Segal, M. and F.E. Bloom. Brain Res. 72: 99, 1974b.PubMedCrossRefGoogle Scholar
  67. 67.
    Segal, M. and F.E. Bloom. Brain Res. 107: 499, 1976a.PubMedCrossRefGoogle Scholar
  68. 68.
    Segal, M. and F.E. Bloom. Brain Res. 107: 513, 1976b.PubMedCrossRefGoogle Scholar
  69. 69.
    Siggins, G.R. In: Psychppharmacology: A Generation of Progress. edited by M.A. Lipton, A. diMascio, and K. Killam. New York: Raven Press, 1978, p. 143.Google Scholar
  70. 70.
    Siggins, G.R., D.L. Gruol, A.L. Padjen, and D.S. Forman. Nature 270: 263, 1977.PubMedCrossRefGoogle Scholar
  71. 71.
    Siggins, G.R., B.J. Hoffer, and F.E. Bloom. Science 165: 1018, 1969.PubMedCrossRefGoogle Scholar
  72. 72.
    Siggins, G.R., B.J. Hoffer, and F.E. Bloom. Brain Res. 25: 535, 1971a.PubMedCrossRefGoogle Scholar
  73. 73.
    Siggins, G.R., A.P. Oliver, B.J. Hoffer, and F.E. Bloom. Science 171: 192, 1971b.PubMedCrossRefGoogle Scholar
  74. 74.
    Siggins, G.R., B.J. Hoffer, A.P. Oliver, and F.E. Bloom. Nature 233: 481, 1971c.PubMedCrossRefGoogle Scholar
  75. 75.
    Stein, L. Nebr. Symp. Motiv. 22: 113, 1975.PubMedGoogle Scholar
  76. 76.
    Stone, T.W. and D.A. Taylor. J. Physiol. 266: 523, 1977.PubMedGoogle Scholar
  77. 77.
    Swanson, L. Brain Res. 128: 346, 1977.PubMedCrossRefGoogle Scholar
  78. 78.
    Tomkins, G. Science 189: 760, 1975.PubMedCrossRefGoogle Scholar
  79. 79.
    Uhl, G., J. Bennett, and S. Snyder. Brain Res. 130: 299, 1977.PubMedCrossRefGoogle Scholar
  80. 80.
    Uhi, G., M. Kuhar, and S. Snyder. Proc. Nat. Acad. Sci. U.S.A. 74: 4059, 1977.CrossRefGoogle Scholar
  81. 81.
    U’Prichard, D.C. and S.H. Snyder. Life Sci. 20: 527, 1977.PubMedCrossRefGoogle Scholar
  82. 82.
    Wang, R.Y. and G.K. Aghajanian. Brain Res. 120: 85, 1977.PubMedCrossRefGoogle Scholar
  83. 83.
    Weight, F.F. In: The Neurosciences—Third Study Programk edited by F.O. Schmitt, F.G. Worden. Cambridge: MIT Press, 1974, p. 929.Google Scholar
  84. 84.
    Zieglgansberger, W. and J. Champagnat. Brain Res.. 1978, in press.Google Scholar
  85. 85.
    Zieglgansberger, W. and J.P. Fry. In: Opiates and Endogenous Opioid Peptides, edited by H. Kosterlitz. Amsterdam: Elsevier/North Holland Biomedical Press, 1976, p. 231.Google Scholar

Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Floyd E. Bloom
    • 1
  1. 1.Arthur Vining Davis Center for Behavioral NeurobiologyThe Salk InstituteLa JollaUSA

Personalised recommendations