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Cyclic Nucleotide and Protein Phosphorylation Mechanisms in the Central Nervous System

  • Paul Greengard
Part of the Published Nobel Symposia book series (NOFS, volume 42)

Abstract

In the past few years, a beginning has been made in understanding the molecular basis by which the activity of nerve cells is regulated. As in the case with hormones acting on non-neuronal tissues (1), there is now evidence that cyclic AMP may act as an intracellular mediator for the actions of certain neurotransmitters on nerve cells (for recent reviews, see 2–8). There is also evidence that certain of the effects of some other neurotransmitters on their target cells may be mediated by cyclic GMP (2–8). In addition, there is now evidence that receptor-second messenger systems can be utilized for two types of modulation of synaptic transmission (Figure 1). Thus, the postsynaptic cell of the receptor-second messenger modulatory synapse can be either the presynaptic or the postsynaptic cell of the synapse being modulated. In other words, the receptor-second messenger system can be utilized for either presynaptic (Figure 1A) or postsynaptic (Figure 1B) modulation of synaptic transmission. In addition to mediating the effects of modulator neurons on the permeability properties of input and output neurons, cyclic nucleotides appear to have many other roles in neuronal function (4,5,8).

Keywords

Adenylate Cyclase Protein Phosphorylation Cyclic Nucleotide Dependent Protein Kinase Postsynaptic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Paul Greengard
    • 1
  1. 1.Department of PharmacologyYale University School of MedicineNew HavenUSA

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