Radionuclide Incorporation via Organoboranes

  • George W. Kabalka


The role of organoboranes in organic synthesis has expanded immensely since Professor Brown first reported their simple preparation via hydroboration.1,2 Examination of the current literature leads to the conclusion that the expansion is far from over. Certainly the presentations at this symposium support such a conclusion.


Boron Atom Label Carbon Deuterium Incorporation Boron Hydride Halogenation8 Reaction 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    H. C. Brown and B. C. Subba Rao, J. Am. Chem. Soc., 78, 5694 (1956).CrossRefGoogle Scholar
  2. 2.
    H. C. Brown, “Hydroboration,” W. A. Benjamin, New York, N.Y., (1962).Google Scholar
  3. 3.
    H. C. Brown, “Boranes in Organic Chemistry,” Cornell University Press, Ithaca, N.Y. (1972).Google Scholar
  4. 4.
    H. C. Brown, “Organic Syntheses Via Boranes,” Wiley-Interscience, New York, N.Y. (1975).Google Scholar
  5. 5.
    G. M. Cragg, “Organoboranes in Organic Synthesis,” Dekker, New York, N.Y. (1973).Google Scholar
  6. 6.
    D. E. Bergbreiter and D. P. Rainville, J. Am. Chem. Soc., 98, 1290 (1976).CrossRefGoogle Scholar
  7. 7.
    H. L. Goering and S. L. Trenbeath, J. Am. Chem. Soc., 98, 5016 (1976).CrossRefGoogle Scholar
  8. 8.
    H. C. Brown, N. R. DeLue, G. W. Kabalka, and H. C. Hedgecock, Jr., J. Am. Chem. Soc., 98, 1290 (1976).CrossRefGoogle Scholar
  9. 9.
    R. C. Larock and H. C. Brown, J. Am. Chem. Soc., 92, 2467 (1970).CrossRefGoogle Scholar
  10. 10.
    Y. Yamomoto, H. Yatagai, K. Maruyama, A. Sonoda, and S. Murahashi, J. Am. Chem. Soc., 99, 5652 (1977).CrossRefGoogle Scholar
  11. 11.
    H. C. Brown, N. C. Hebert, and C. H. Snyder, J. Am. Chem. Soc., 83, 1001 (1961).Google Scholar
  12. 12.
    G. W. Kabalka, R. J. Newton, and J. Jacobus, J. Org. Chem., 42, 1567 (1978).CrossRefGoogle Scholar
  13. 13.
    A. P. Wolf, D. R. Christman, J. S. Fowler, and R. M. Lambrecht, “Radiopharmaceuticals and Labelled Compounds,” Vol. 1, IAEA, Vienna (1973).Google Scholar
  14. 14.
    C. J. Collins and N. S. Bowman, “Isotope Effects in Chemical Reactions,” ACS Monograph 167, Van Nostrand Reinhold Co., New York, N.Y. (1970).Google Scholar
  15. 15.
    E. Buncel and C. C. Lee, “Isotopes in Organic Chemistry,” Vol. I, Elsevier, Amsterdam, Netherlands (1975).Google Scholar
  16. 16.
    a) H. C. Brown, Acc. Chem. Res., 2, 65 (1969);CrossRefGoogle Scholar
  17. 16.
    b) A. Pelter, M. G. Hutchings, and K. Smith, Chem. Commun., 1048 (1971).Google Scholar
  18. 17.
    E. Negishi, M. Sebanski, J. J. Katz, and H. C. Brown, Tetrahedron, 32, 925 (1976).CrossRefGoogle Scholar
  19. 18.
    R. Freudenthal and P. W. Jones, “Carcinogenesis,” Vol. 1, Raven Press, New York, N.Y. (1971).Google Scholar
  20. 19.
    A. Pelter, M. G. Hutchings, and K. Smith, Chem. Commun., 1529 (1970).Google Scholar
  21. 20.
    K. M. J. Menon and J. R. Reel, “Steroid Hormone Action and Cancer,” Chapters 1 and 9, Plenum Press, New York, N.Y. (1976).Google Scholar
  22. 21.
    G. D. Robinson and F. W. Zielinski, J. Labelled Compd. Radiopharm., XIII, 220 (1977).Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • George W. Kabalka
    • 1
  1. 1.Chemistry DepartmentUniversity of TennesseeKnoxvilleUSA

Personalised recommendations