Antibodies to Allozymes as Potential Cell Markers for Chimeric Mouse Studies

  • John Gearhart
  • Mary Lou Oster-Granite
Part of the Basic Life Sciences book series (BLSC, volume 12)


The limiting factor in the use of mouse chimeras for the revelation of detailed fate maps during embryogenesis is the lack of suitable cell marker systems. This limitation is evident when the list of available chimeric or mosaic markers is examined and compared to the criteria for an ideal marker system. An ideal cell marker should (1) be expressed in all descendants of a cell; (2) be present in all cells of a tissue or organism; (3) be cell autonomous; (4) be cell localized; (5) exist in variant forms which are selectively neutral; (6) have variant forms which can be detected in histologic sections; and (7) have variants which are expressed early in embryogenesis.


Cell Marker Marker System Bergmann Glial Cell Cellulose Phosphate Mouse Chimera 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • John Gearhart
    • 1
  • Mary Lou Oster-Granite
    • 1
  1. 1.Department of Anatomy, School of MedicineUniversity of MarylandBaltimoreUSA

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