The Use of Mosaics and Experimental Chimeras to Study the Pathogenesis of Neoplasia
Electrophoretic variants of X-linked enzymes have been exploited to study the cellular origins of tumors (Fialkow 1976; Gartler 1974). Gartler and Linder first demonstrated that three lipomas, arising in females heterozygous for electrophoretic variants of Gd, the gene coding for glucose-6-phosphate dehydrogenase, were composed of cells that produced mainly one variant when both were expected (Gartler and Linder 1964).
KeywordsElectrophoretic Pattern Swiss Albino Mouse Chimeric Mouse Glucose Phosphate Isomerase Clone Size
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