The Use of Mosaics and Experimental Chimeras to Study the Pathogenesis of Neoplasia

  • Philip M. Iannaccone
Part of the Basic Life Sciences book series (BLSC, volume 12)


Electrophoretic variants of X-linked enzymes have been exploited to study the cellular origins of tumors (Fialkow 1976; Gartler 1974). Gartler and Linder first demonstrated that three lipomas, arising in females heterozygous for electrophoretic variants of Gd, the gene coding for glucose-6-phosphate dehydrogenase, were composed of cells that produced mainly one variant when both were expected (Gartler and Linder 1964).


Electrophoretic Pattern Swiss Albino Mouse Chimeric Mouse Glucose Phosphate Isomerase Clone Size 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Philip M. Iannaccone
    • 1
  1. 1.University of California at San Diego, University HospitalSan DiegoUSA

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