Advertisement

The Use of Mosaics and Experimental Chimeras to Study the Pathogenesis of Neoplasia

  • Philip M. Iannaccone
Part of the Basic Life Sciences book series (BLSC, volume 12)

Abstract

Electrophoretic variants of X-linked enzymes have been exploited to study the cellular origins of tumors (Fialkow 1976; Gartler 1974). Gartler and Linder first demonstrated that three lipomas, arising in females heterozygous for electrophoretic variants of Gd, the gene coding for glucose-6-phosphate dehydrogenase, were composed of cells that produced mainly one variant when both were expected (Gartler and Linder 1964).

Keywords

Electrophoretic Pattern Swiss Albino Mouse Chimeric Mouse Glucose Phosphate Isomerase Clone Size 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bauer, K. H. 1928. Mutationstheorie der Geschwulstentstehung. Springer-Verlag, Berlin.CrossRefGoogle Scholar
  2. Boveri, T. 1914. Zur Frage der Entstehung maligner Tumoren. Gustav Fisher (Jena), translated by Boveri, M. (1929). Williams & Wilkins (Baltimore).Google Scholar
  3. Chapman, V. M., W. K. Whitten and F. H. Ruddle. 1971. Expression of paternal glucose phosphate isomerase-1 (Gpi-1) in preimplantation stages of mouse embryos. Devel. Biol. 26: 153–158.CrossRefGoogle Scholar
  4. Domb, C. and M. F. Sykes. 1960. Cluster size in random mixtures and percolation processes. Phys. Rev. 122: 77–78.CrossRefGoogle Scholar
  5. Fialkow, P. J. 1976. Clonal origin of human tumors. Biochim. Biophys. Acta 458: 283–321.PubMedGoogle Scholar
  6. Fialkow, P. J., R. W. Sagebiel, S. M. Gartler and D. L. Rimoin. 1971. Multiple cell origin of hereditary neurofibromas. New England J. Med. 284: 298–300.CrossRefGoogle Scholar
  7. Friedman, J. M. and P. J. Fialkow. 1976. Viral “tumorigenesis” in man: cell markers in Condyloma accuminata. Int. J. Cancer 17: 57–61.Google Scholar
  8. Gardner, R. L. Production of chimeras by injecting cells or tissue into the blastocyst. In Methods in Mammalian Embryology, Vol. II (in press).Google Scholar
  9. Gartler, S. M. 1974. Utilization of mosaic systems in the study of the origin and progression of tumors. In Chromosomes and Cancer, J. German, Ed., pp. 313–334. Wiley, New York.Google Scholar
  10. Gartler, S. M. and D. Linder. 1964. Selection in mammalian mosaic cell populations. Cold Spring Harbor Symp. Quant. Biol. 29: 253–260.CrossRefGoogle Scholar
  11. Hutchison, H. T. 1973. A model for estimating the extent of variegation in mosaic tissues. J. Theor. Biol. 38: 61–79.PubMedCrossRefGoogle Scholar
  12. Iannaccone, P. M., R. L. Gardner and H. Harris. 1978. The cellular origin of chemically induced tumors. J. Cell Science 29: 249–269.PubMedGoogle Scholar
  13. Linder, D. and S. M. Gartler. 1965. Problem of single cell versus multi-cell origin of a tumor. Proc. 5th Berkeley Symp. on Math. Statis. and Probab. 625–633.Google Scholar
  14. Linder, D. and S. M. Gartier. 1965a. Glucose-6-phosphate dehydrogenase mosaicism: utilization as a cell marker in the study of leiomyomas. Science 150: 67–69.PubMedCrossRefGoogle Scholar
  15. Morgan, T. H. and C. B. Bridges. 1919. Contributions to the genetics of Drosophila melanogaster. The Carnegie Institution (Washington) p. 108.Google Scholar
  16. Nesbitt, M. N. 1974. Chimeras vs. X inactivation mosaics: significance of differences in pigment distribution. Develop. Biol. 38: 202–207.PubMedCrossRefGoogle Scholar
  17. Ohno, S. 1971. Genetic implication of karyological instability of malignant somatic cells. Physiol. Rev. 51: 496–526: see p. 500.Google Scholar
  18. Wegmann, T. G. 1970. Enzyme patterns in tetraparental mouse liver. Nature 225: 462–463.CrossRefGoogle Scholar
  19. West, J. D. 1975. A theoretical approach to the relation between patch size and clone size in chimeric tissue. J. Theor. Biol. 50: 153–160.PubMedCrossRefGoogle Scholar
  20. Willis, R. A. 1967. Pathology of Tumours. 4th edition. Butterworths, London.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Philip M. Iannaccone
    • 1
  1. 1.University of California at San Diego, University HospitalSan DiegoUSA

Personalised recommendations