An Analysis of Differentiation in Coaggregation Cultures between Mouse Neuronal and Tumor Cells
Evidence exists that indicates interactions at the plasma-membrane surface of embryonic cells are involved in directing morphogenesis during early development (Saxen and Toivonen 1962). Consequently, a considerable effort has been directed at understanding the molecular basis of specific cell-to-cell interactions, and in particular at identifying and characterizing specific molecules on the plasma-membrane surface that mediate or specify these interactions (Roth and Weston 1967; Steinberg 1970; Merrell and Glaser 1973; Hausman and Moscona 1975; Rutishauser, Thiery, Brackenbury, Sela, and Edelman 1976). Although considerable progress has been made in characterizing macromolecules on the surface that affect cell adhesion, before an understanding of the molecular biology of cell-to-cell interactions and their role in differentiation can be achieved, specific genes must be identified whose expressions are modulated as a consequence of interactions at the cell surface.
KeywordsHyaluronic Acid Neuroblastoma Cell Mouse Cerebellum Cerebellar Cell Biochemical Differentiation
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