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An Analysis of Differentiation in Coaggregation Cultures between Mouse Neuronal and Tumor Cells

  • Leslie P. Kozak
Part of the Basic Life Sciences book series (BLSC, volume 12)

Abstract

Evidence exists that indicates interactions at the plasma-membrane surface of embryonic cells are involved in directing morphogenesis during early development (Saxen and Toivonen 1962). Consequently, a considerable effort has been directed at understanding the molecular basis of specific cell-to-cell interactions, and in particular at identifying and characterizing specific molecules on the plasma-membrane surface that mediate or specify these interactions (Roth and Weston 1967; Steinberg 1970; Merrell and Glaser 1973; Hausman and Moscona 1975; Rutishauser, Thiery, Brackenbury, Sela, and Edelman 1976). Although considerable progress has been made in characterizing macromolecules on the surface that affect cell adhesion, before an understanding of the molecular biology of cell-to-cell interactions and their role in differentiation can be achieved, specific genes must be identified whose expressions are modulated as a consequence of interactions at the cell surface.

Keywords

Hyaluronic Acid Neuroblastoma Cell Mouse Cerebellum Cerebellar Cell Biochemical Differentiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Leslie P. Kozak
    • 1
  1. 1.The Jackson LaboratoryBar HarborUSA

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