Data Analysis of Four X-Chromosome Inactivation Experiments

  • Victor E. Kane
Part of the Basic Life Sciences book series (BLSC, volume 12)


Some experiments on mosaics result in data that suggest one or more developmental models usually consisting of alternative biological processes having several unknown parameters. If each experimental subject responded in an identical fashion, a mathematical formulation might be appropriate. However, since random fluctuations are often inherent in the developmental system, a statistical model incorporating randomness is necessary. This paper presents the biological assumptions and a developmental model which appear to be used in data analysis of four experiments (Nesbitt 1971; Fialkow 1973; Nance 1964; and Migeon 1971). The simplest statistical estimation scheme is presented here; complete details are given elsewhere (Kane 1975). The emphasis is on the results of the parameter estimates and on hypothesis testing in the four experiments.


Cell Pool Moment Estimator Binomial Sampling Biological Assumption Organ Determination 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Victor E. Kane
    • 1
  1. 1.Mathematics and Statistics Research Department, Computer Sciences Division, Nuclear DivisionUnion Carbide CorporationOak RidgeUSA

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