Data Analysis of Four X-Chromosome Inactivation Experiments
Some experiments on mosaics result in data that suggest one or more developmental models usually consisting of alternative biological processes having several unknown parameters. If each experimental subject responded in an identical fashion, a mathematical formulation might be appropriate. However, since random fluctuations are often inherent in the developmental system, a statistical model incorporating randomness is necessary. This paper presents the biological assumptions and a developmental model which appear to be used in data analysis of four experiments (Nesbitt 1971; Fialkow 1973; Nance 1964; and Migeon 1971). The simplest statistical estimation scheme is presented here; complete details are given elsewhere (Kane 1975). The emphasis is on the results of the parameter estimates and on hypothesis testing in the four experiments.
KeywordsCell Pool Moment Estimator Binomial Sampling Biological Assumption Organ Determination
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- Kane, V. E. 1975. Statistical models for X chromosome inactiva-tion. Ph.D. Dissertation, Florida State University.Google Scholar
- Kane, V. E. 1978. Stochastic models for X chromosome inactivation. Submitted.Google Scholar
- Migeon, B. R. 1971. Studies of skin fibroblasts from 10 families with HGPRT deficiency, with reference to X-chromosome inactivation. Am. J. of Human Genet. 23: 199–210.Google Scholar
- Nesbitt, M. N. 1970. X chromosome inactivation mosaicism in the mouse. Ph.D. Dissertation, University of Washington.Google Scholar
- Nesbitt, M. N. 1972. Personal communication.Google Scholar