Abstract
Mosaics are arrays of two or more alternatives which may be in one, two, or three dimensions, and for each of which there are many biological examples. Before we can discuss the biological material intelligently, it is essential to determine some of the parameters of purely random mosaics. The most obvious attributes of mosaics are patchiness, and the variation in patchiness. I shall use the terms run, patch, and cluster to describe aggregates of like cells in one-, two-, and three-dimensional mosaics, respectively.
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References
Feder, N. 1976. Solitary cells and enzyme exchange in tetrapa-rental mice. Nature 263: 67–69.
Gardner, R. L. 1968. Mouse chimaeras obtained by the injection of cells into the blastocyst. Nature 220: 596–597.
Lyon, M. F. 1970. Genetic activity of sex chromosomes in somatic cells of mammals. Phil. Trans. Roy. Soc. London B. 259: 41–52.
Mintz, B. 1971. Clonal basis of mammalian differentiation. Control mechanisms of growth and differentiation. Symp. Soc. Exp. Biol. 25: 345–370.
Nesbitt, M. W. 1974. Chimerics vs. X inactivation mosaics: significance of differences in pigment distribution. Develop. Biol. 58: 202–207.
Roach, S. A. 1968. The Theory of Random Clumping. Methuen, London.
Stevens, W. L. 1939. Distribution of groups in a sequence of alternatives. Ann. Eugenics 9: 10–17.
Thompson, D. W. 1948. On Growth and Form. 2nd ed. McMillan, New York.
Wegmann, T. G. 1970. Enzyme patterns in tetraparental mouse liver. Nature 225: 462–463.
West, J. D. 1975. A theoretical approach to the relation between patch size and clone size in chimeric tissue. J. Theor. Biol. 50: 153–160.
Wolpert, T. G. and D. Gingell. 1970. Striping and the pattern of melanocyte cells in chimaeric mice. J. Theor. Biol. 29: 147–150.
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Dedicated to the memory of the late Robert S. Rupp whose perseverance and keen three-dimensional insight made this study possible.
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© 1978 Plenum Press, New York
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Whitten, W.K. (1978). Combinatorial and Computer Analysis of Random Mosaics. In: Russell, L.B. (eds) Genetic Mosaics and Chimeras in Mammals. Basic Life Sciences, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3390-6_30
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DOI: https://doi.org/10.1007/978-1-4684-3390-6_30
Publisher Name: Springer, Boston, MA
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