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Ovarian Teratomas in Mice are Derived from Oocytes That Have Completed the First Meiotic Division

  • John J. Eppig
  • Leslie P. Kozak
  • Eva M. Eicher
  • Leroy C. Stevens
Part of the Basic Life Sciences book series (BLSC, volume 12)

Abstract

Spontaneous ovarian teratomas are found in about 50% of strain LT/Sv mice by the time they are 90 days old (Stevens and Varnum 1974). These teratomas result from parthenogenetic cleavage of ovarian oocytes. Some parthenotes reach a developmental stage equivalent to 7 d embryo before they become disorganised and further develop into a teratoma. Since some cleaved ovarian oocytes are accompanied by polar bodies, but others seem to lack them, it was uncertain whether the teratomas derive from oocytes that complete the first meiotic division or from oocytes that cleave mitotically without previous meiotic division.

Keywords

Ovarian Tissue Polar Body Meiotic Division Glucose Phosphate Isomerase Ovarian Teratoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Linder, D. 1969. Proc. Natl. Acad. Sci. USA 63: 699–704.PubMedCrossRefGoogle Scholar
  2. Stevens, L. C. and D. S. Varnum. 1974. Devel. Biol. 21: 364–382.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • John J. Eppig
    • 1
  • Leslie P. Kozak
    • 1
  • Eva M. Eicher
    • 1
  • Leroy C. Stevens
    • 1
  1. 1.The Jackson LaboratoryBar HarborUSA

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