Abstract
Rearrangements between mammalian X chromosomes and autosomes are valuable tools in the study of X inactivation, since they provide a karyotype in which the physical continuity of the X chromosome is interrupted. In reciprocal X-autosome translocations, T(X;A)’s, there are three chromosomes within each cell of a heterozygote — instead of the usual two — that contain X-chromosome material. This circumstance may be put to use in addressing questions of X-differentiation mechanisms and randomness.
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Russell, L.B., Cacheiro, N.L.A. (1978). The Use of Mouse X-Autosome Translocations in the Study of X-Inactivation Pathways and Nonrandomness. In: Russell, L.B. (eds) Genetic Mosaics and Chimeras in Mammals. Basic Life Sciences, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3390-6_27
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DOI: https://doi.org/10.1007/978-1-4684-3390-6_27
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