The Use of Mouse X-Autosome Translocations in the Study of X-Inactivation Pathways and Nonrandomness

  • Liane B. Russell
  • Nestor L. A. Cacheiro
Part of the Basic Life Sciences book series (BLSC, volume 12)


Rearrangements between mammalian X chromosomes and autosomes are valuable tools in the study of X inactivation, since they provide a karyotype in which the physical continuity of the X chromosome is interrupted. In reciprocal X-autosome translocations, T(X;A)’s, there are three chromosomes within each cell of a heterozygote — instead of the usual two — that contain X-chromosome material. This circumstance may be put to use in addressing questions of X-differentiation mechanisms and randomness.


Adult Kidney Fetal Kidney Autosomal Locus Genetic Mosaic Trans Location 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Liane B. Russell
    • 1
  • Nestor L. A. Cacheiro
    • 1
  1. 1.Biology DivisionOak Ridge National LaboratoryOak RidgeUSA

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