Preferential Expression of the Maternally Derived X Chromosome in Extraembryonic Tissues of the Mouse

  • John D. West
  • Virginia E. Papaioannou
  • William I. Frels
  • Verne M. Chapman
Part of the Basic Life Sciences book series (BLSC, volume 12)


Nonrandom X-chromosome expression in XX female mammals has been reported in several different situations. For example, when one X chromosome carries a deletion, only the normal X chromosome is expressed (Grumbach, Morishima, and Taylor 1963), but when one X chromosome is involved in a certain reciprocal X-autosome translocation* — Searle’s translocation in mice (reviewed by Eicher 1970) — only the abnormal X chromosome is expressed. Similar exclusive expression of one X chromosome has been reported in the blood of certain human X-inactivation mosaics (Nance 1964; Gandini, Gartler, Angioni, Argiolas, and Dell’Acqua 1968), and this observation is most consistently made when the absent blood-cell population would express a deleterious X-linked gene, such as an HPRT deficiency (Nyhan, Bakay, Connor, Marks, and Keel 1970). Less extreme cases of nonrandom X-chromosome expression have been reported in some tissues of humans (Nance 1964; Ropers, Wienker, Grimm, Schroetter, and Bender 1977) and mules (Hook and Brustman 1971), and for various stocks of mice apparently heterozygous for an X-linked controlling-element locus (Cattanach and Isaacson 1965; Grahn, Lea, and Hulesch 1970; Krzanowska and Wabik 1971; Falconer and Isaacson 1972; Ohno, Christian, Attardi, and Kan 1973).


Fabry Disease Preferential Expression Extraembryonic Tissue Primitive Endoderm Genetic Mosaic 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • John D. West
    • 1
  • Virginia E. Papaioannou
    • 1
  • William I. Frels
    • 2
  • Verne M. Chapman
    • 2
  1. 1.Department of ZoologyUniversity of OxfordOxfordEngland
  2. 2.Department of Molecular BiologyRoswell Park Memorial InstituteBuffaloUSA

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