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Preferential Expression of the Maternally Derived X Chromosome in Extraembryonic Tissues of the Mouse

  • John D. West
  • Virginia E. Papaioannou
  • William I. Frels
  • Verne M. Chapman
Part of the Basic Life Sciences book series (BLSC, volume 12)

Abstract

Nonrandom X-chromosome expression in XX female mammals has been reported in several different situations. For example, when one X chromosome carries a deletion, only the normal X chromosome is expressed (Grumbach, Morishima, and Taylor 1963), but when one X chromosome is involved in a certain reciprocal X-autosome translocation* — Searle’s translocation in mice (reviewed by Eicher 1970) — only the abnormal X chromosome is expressed. Similar exclusive expression of one X chromosome has been reported in the blood of certain human X-inactivation mosaics (Nance 1964; Gandini, Gartler, Angioni, Argiolas, and Dell’Acqua 1968), and this observation is most consistently made when the absent blood-cell population would express a deleterious X-linked gene, such as an HPRT deficiency (Nyhan, Bakay, Connor, Marks, and Keel 1970). Less extreme cases of nonrandom X-chromosome expression have been reported in some tissues of humans (Nance 1964; Ropers, Wienker, Grimm, Schroetter, and Bender 1977) and mules (Hook and Brustman 1971), and for various stocks of mice apparently heterozygous for an X-linked controlling-element locus (Cattanach and Isaacson 1965; Grahn, Lea, and Hulesch 1970; Krzanowska and Wabik 1971; Falconer and Isaacson 1972; Ohno, Christian, Attardi, and Kan 1973).

Keywords

Fabry Disease Preferential Expression Extraembryonic Tissue Primitive Endoderm Genetic Mosaic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • John D. West
    • 1
  • Virginia E. Papaioannou
    • 1
  • William I. Frels
    • 2
  • Verne M. Chapman
    • 2
  1. 1.Department of ZoologyUniversity of OxfordOxfordEngland
  2. 2.Department of Molecular BiologyRoswell Park Memorial InstituteBuffaloUSA

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