Preferential Inactivation of the Paternally Derived X Chromosome in Mice
Random X-chromosome inactivation makes the female of placental mammals a natural mosaic for clones of cells having either the maternally derived X (Xm) or paternally derived one (XP) genetically inactivated (Lyon 1961). In marsupials, on the other hand, preferential inactivation of the paternally inherited X chromosome seems to be a rule in most tissues (Sharman 1971; Cooper, Johnston, Murtagh, Sharman, VandeBerg, and Poole 1975). There are, however, instances in which inactivation is obviously not random in placental mammals (Lyon 1974). Nonrandomness was assessed from studies made on differentiated cells remote from early embryonic cells in which inactivation occurred. Thus it is not clear whether nonrandom inactivation, or a secondary event(s) after random inactivation, was responsible for the ultimate nonrandom expression.
KeywordsPrimitive Endoderm Preimplantation Mouse Embryo Embryonic Region Extraembryonic Mesoderm Random Inactivation
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