Use of the Sex Reversed Gene (Sxr) to Investigate Functional Sex Reversal and Gonadal Determination in Mammals

  • Jon Gordon
Part of the Basic Life Sciences book series (BLSC, volume 12)


Functional sex reversal is a well established phenomenon in many classes of organisms and demonstrates that sex determination in those organisms is influenced by the extra-embryonic environment. Experimental reversal of chromosomally male Xenopus laevis embryos to functional females has been accomplished by adding estrogens to the water in which these embryos develop (Chang and Witschi 1955; Gallien 1955). Chromosomally male embryos of the fish Oryziat latipes have been similarly reversed by estrogens (Yamamoto 1953, 1955), and female embryos of this same species have been reversed to functional males with testosterone (Yamamoto 1958). Other experiments have reversed males of Amblystoma maculatum (Foote 1940, 1941) and of the urodele, Fleurodeles waltlii (Gallien 1950, 1951).


Germ Cell Seminiferous Tubule Primordial Germ Cell Genital Ridge Testicular Differentiation 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Jon Gordon
    • 1
  1. 1.Department of BiologyYale UniversityNew HavenUSA

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