Reversion of Malignancy and Normalized Differentiation of Teratocarcinoma Cells in Chimeric Mice

  • Karl Illmensee
Part of the Basic Life Sciences book series (BLSC, volume 12)


In this review, I should like briefly to summarize some new approaches in experimental research on mouse teratocarcinomas. During the past few years, these tumors have been tested for their developmental potential, genetic constitution, and state of neoplastic transformation in the living organism, using microsurgery to introduce the malignant stem cells into early mouse embryos. What exactly are teratocarcinomas, and why are they becoming such a useful tool in analyzing gene expression during mammalian differentiation?


Thymidine Kinase Hybrid Cell Embryoid Body Chimeric Mouse Embryonal Carcinoma Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Karl Illmensee
    • 1
  1. 1.Department of BiologyUniversity of GenevaSwitzerland

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