Report of the Summation Committee: Recommended Areas for Future Research
For several years it has been known that mucosal surfaces have common immunologic characteristics. The first such characteristic is that the predominant immunoglobulin is dimeric, US IgA (secretory IgA, s-IgA). It has been shown that large numbers of T-lymphocytes are present on mucosal surfaces and seem to participate in local immune reactions. Despite an awareness that s-IgA provides protection against mucosal viral infections by neutralizing viruses, considerable confusion has existed regarding its protection against bacterial infections. Recent findings have established that s-IgA antibodies in the gastrointestinal and respiratory tracts mediate protection by such mechanisms as limiting adherence of bacteria to epithelial cells, inhibiting bacterial motility, and interfering with the uptake of macromolecular substances from the gastrointestinal tract; other mechanisms for such protection remain to be elucidated.
KeywordsMucosal Surface Mucosal Immunity Local Immune Reaction Antigenic Drift Macromolecular Substance
Unable to display preview. Download preview PDF.