Salivary Immunoglobulins in Diseases Affecting Salivary Glands

  • Irwin D. Mandel
  • Harold Baurmash
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)


Examination of salivary secretions from healthy subjects in a number of laboratories has been helpful in the elucidation of the nature and function of the secretory immune system. Additional information on local synthesis and transport has been provided by study of salivary secretions from individuals with either defective or excessive synthesis of serum immunoglobulins (1). Further insight might be provided by analysis of salivary fluids in inflammatory disorders of the salivary glands or in selected systemic diseases which affect the structure, function or synthetic capacity of the glands. Based on our observations on sialochemical changes in a variety of clinical situations (2,3) we selected chronic recurrent parotitis, Sjogren’s Disease, alcoholic cirrhosis, adult and juvenile onset diabetes and hemodialysis for chronic renal disease for further examination. In all instances saliva was collected directly from the parotid or submaxillary glands, or both, and flow rate and concentrations of immunoglobulins and albumin were measured.


Salivary Gland Alcoholic Cirrhosis Salivary Secretion Parotid Saliva Salivary Gland Function 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Irwin D. Mandel
    • 1
  • Harold Baurmash
    • 1
  1. 1.Divisions of Preventive Dentistry and Oral Surgery, School of Dental and Oral SurgeryColumbia UniversityNew YorkUSA

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