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Dextran Receptors as Immunogens in Caries Prophylaxis

  • Gerald A. Olson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)

Abstract

Understanding of the basic mechanisms of bacterial adherence of cariogenic bacteria to smooth surfaces is essential to developing effective control measures for inhibiting plaque formation and dental caries. Bacteria of the species Streptococcus mutans are strongly implicated as causative agents (1). Their ability to adhere to smooth surfaces is directly related to glucan synthesis by bacterial glucosyltransferases (2). Recent investigations indicate the existence of receptors on the cell surface which bind extracellular glucans (3,4). These receptors are distinct from glucosyltransferase and bind either soluble dex-trans or insoluble glucans (mutans). This study described the purification and use of dextran receptors in immunization of experimental rats and evaluation of the effects of immunization on subsequent challenge under caries-promoting conditions.

Keywords

Dental Caries Serum Titer Saturated Ammonium Sulfate Adherence Inhibition Cariogenic Bacterium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Gerald A. Olson
    • 1
    • 2
  1. 1.Animal Resource DivisionUniversity of Tennessee Center for the Health SciencesMemphisUSA
  2. 2.J. Hillis Miller Health CenterUniversity of FloridaUSA

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