Dextran Receptors as Immunogens in Caries Prophylaxis
Understanding of the basic mechanisms of bacterial adherence of cariogenic bacteria to smooth surfaces is essential to developing effective control measures for inhibiting plaque formation and dental caries. Bacteria of the species Streptococcus mutans are strongly implicated as causative agents (1). Their ability to adhere to smooth surfaces is directly related to glucan synthesis by bacterial glucosyltransferases (2). Recent investigations indicate the existence of receptors on the cell surface which bind extracellular glucans (3,4). These receptors are distinct from glucosyltransferase and bind either soluble dex-trans or insoluble glucans (mutans). This study described the purification and use of dextran receptors in immunization of experimental rats and evaluation of the effects of immunization on subsequent challenge under caries-promoting conditions.
KeywordsDental Caries Serum Titer Saturated Ammonium Sulfate Adherence Inhibition Cariogenic Bacterium
Unable to display preview. Download preview PDF.
- 5.Taubman, M. A. and Smith, D. J., Infect. Immun. 9: 1079, 1974.Google Scholar
- 10.Nelson, N., J. Biol. Chem. 153: 275, 1944.Google Scholar
- 11.McCabe, M. M. and Smith, E. E., in Immunologic Aspects of Dental Caries, special supplement to Immunology Abstracts, 1976.Google Scholar
- 13.Bowen, W. H., in Immunologic Aspects of Dental Caries, special supplement to Immunology Abstracts, 1976.Google Scholar