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Dextran/Glucan Binding by Streptococcus Mutans: The Role of Molecular Size and Binding Site in Agglutination

  • Christine D. Wu-Yuan
  • Stella Tai
  • Hutton D. Slade
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)

Abstract

Streptococcus mutans cells are known to agglutinate in the presence of glucan synthesized from sucrose by cell-associated glucosyltransferase (GTF, 1,2). Soluble dextrans of high molecular weight also induce cell agglutination, whereas levan, starch and inulin or dextran of low molecular weight were ineffective (3). It was shown that heat-treated cells did not agglutinate and it was suggested that the cells possess specific surface binding sites which are capable of binding dextran and thereby causing agglutination (3). Binding studies using 14C-labeled glucan or dextran of MW 1 × 104 to 2 × 106 d emonstrated that these polymers bind to S. mutans cells (2–6). However, the significance of this binding in relation to cell agglutination was not described.

Keywords

Dental Caries Streptococcus Mutans Public Health Service Research Cell Agglutination Dextran Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Christine D. Wu-Yuan
    • 1
  • Stella Tai
    • 1
  • Hutton D. Slade
    • 1
  1. 1.Department of Microbiology-ImmunologyNorthwestern University Medical and Dental SchoolsChicagoUSA

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