Streptococcus Mutans Dextransucrase: Phosphoglycerides and the Detection of Inhibitory Antibodies in Sera

  • Charles F. Schachtele
  • Susan K. Harlander
  • Lee C. Ostrum
  • James W. Bracke
  • James L. Babb
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)


The cariogenic potential of the oral bacteria collectively called Streptococcus mutans has been shown by various types of investigations to be directly related to the production of extracellular enzyme activities capable of converting the glucosyl moiety of sucrose into polysaccharide. Variant isolates which produce elevated or diminished levels of dextransucrase (EC have been shown to have correspondingly increased or decreased cariogenicity when tested in animal models (1–3). This direct relationship between enzyme activity and cariogenicity makes dextransucrase a good candidate antigen for a vaccine against dental caries.


Dental Caries Human Seron Stimulation Site Normal Rabbit Serum Immune Serum 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Charles F. Schachtele
    • 1
  • Susan K. Harlander
    • 1
  • Lee C. Ostrum
    • 1
  • James W. Bracke
    • 1
  • James L. Babb
    • 2
  1. 1.School of DentistryUniversity of MinnesotaMinneapolisUSA
  2. 2.Department of MicrobiologyUniversity of Alabama in BirminghamBirminghamUSA

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