Streptococcus Mutans Dextransucrase: Phosphoglycerides and the Detection of Inhibitory Antibodies in Sera
The cariogenic potential of the oral bacteria collectively called Streptococcus mutans has been shown by various types of investigations to be directly related to the production of extracellular enzyme activities capable of converting the glucosyl moiety of sucrose into polysaccharide. Variant isolates which produce elevated or diminished levels of dextransucrase (EC 22.214.171.124) have been shown to have correspondingly increased or decreased cariogenicity when tested in animal models (1–3). This direct relationship between enzyme activity and cariogenicity makes dextransucrase a good candidate antigen for a vaccine against dental caries.
KeywordsDental Caries Human Seron Stimulation Site Normal Rabbit Serum Immune Serum
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- 12.Harlander, S. K. and Schachtele, C. F., Infect. Immun. 19: in press, 1978.Google Scholar