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Use of Mutants in the Elucidation of Virulence of Streptococcus Mutans

  • Shigeo Otake
  • Jerry R. McGhee
  • Masatomo Hirasawa
  • Katherine Williams
  • Roland R. Arnold
  • James L. Babb
  • Hiroshi Kiyono
  • Cindy Cox
  • Suzanne M. Michalek
  • Tetsuo Shiota
  • Tadashi Ikeda
  • Kuniyasu Ochiai
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)

Abstract

In the presence of sucrose, Streptococcus mutans displays certain unique metabolic activities which are believed to be important factors in determining its virulence. Of the various carbohydrates metabolized by S. mutans, only sucrose is utilized for the production of acid, fructans and glucans (1,2). The adhesive water-insoluble glucans have been shown to be most important for the attachment of cells of S. mutans to smooth surfaces (1,3,5); probably both the water-insoluble and water-soluble glucans are required for the cell to cell aggregation which results in plaque production (6,7). Several laboratories have employed bacterial mutants and model systems of cell adherence and aggregation to study the cariogenic nature of S. mutans (5,8–13). We present results of certain biochemical activities of mutants of S. mutans strain 6715 and attempt to relate these findings to the cariogenic and immunogenic nature of these organisms.

Keywords

Parent Type Streptococcus Mutans Sucrose Medium Polysaccharide Antigen Double Immunodiffusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Shigeo Otake
    • 1
  • Jerry R. McGhee
    • 1
  • Masatomo Hirasawa
    • 1
  • Katherine Williams
    • 1
  • Roland R. Arnold
    • 1
  • James L. Babb
    • 1
  • Hiroshi Kiyono
    • 1
  • Cindy Cox
    • 1
  • Suzanne M. Michalek
    • 1
  • Tetsuo Shiota
    • 1
  • Tadashi Ikeda
    • 2
  • Kuniyasu Ochiai
    • 2
  1. 1.Department of Microbiology, Institute of Dental ResearchUniversity of Alabama in BirminghamBirminghamUSA
  2. 2.Department of BacteriologyNihon UniversityMatsudo, Chiba-Ken 271Japan

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