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Discussion

  • Jerry R. McGhee
  • Jiri Mestecky
  • James L. Babb
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)

Abstract

Direct evidence has been presented that suggests that glucans are not directly involved in the initial adherence. There has been indirect evidence presented to suggest that perhaps teichoic acids are involved. This results in a paradox, since non-adherent mutants which have been isolated from adults synthesize insoluble glucans and have diminished or absent glucosyl-transferase activity. It seems to me that this leads to several possibilities—either there is a coordinate regulation stimulated by the presence of sucrose in those components that are involved in adherence as well as in the synthesis of glucans or, alternatively, that glucans form a matrix to allow for the attachment of teichoic acids to the cell surface. This in turn would anchor the cells to the smooth surface of the tooth. I’m wondering if there are data that would directly or indirectly cast light on these alternate possibilities.

Keywords

Tooth Surface Teichoic Acid Initial Adherence Limit Growth Factor Insoluble Polysaccharide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Jerry R. McGhee
    • 1
  • Jiri Mestecky
    • 1
  • James L. Babb
    • 1
  1. 1.Institute of Dental Research, Departments of Microbiology and Medicine, Comprehesive Cancer CenterUniversity of Alabama in BirminghamBirminghamUSA

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