Lipoteichoic Acid — The Key to the Adhesiveness of Sucrose Grown Streptococcus Mutans

  • G. Rölla
  • O.-J. Iversen
  • P. Bonesvoll
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)


Immunization of monkeys with killed S. mutans cells has been claimed to result in a markedly reduced number of this bacterium on tooth surfaces (1). The vaccination approach to prevention of dental caries, which is so strongly represented at the present symposium may thus, as a matter of fact, depend on inhibition of the adherence of cariogenic streptococci. An understanding of the mechanisms involved in binding S. mutans to tooth surfaces may therefore be essential in this area of research.


Dental Caries Plaque Formation Tooth Surface Lipoteichoic Acid Vaccination Approach 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Lehner, T., Caldwell, J. and Challacombe, S. J., Arch. Oral Biol. 22: 393, 1976.CrossRefGoogle Scholar
  2. 2.
    Gibbons, R. J. and Banghart, S. B., Arch. Oral Biol. 12: 11, 1967.PubMedCrossRefGoogle Scholar
  3. 3.
    Guggenheim, B. and Newbrun, E., Helv. Odont. Acta 13: 84, 1969.Google Scholar
  4. 4.
    Guggenheim, B. and Schröder, H. E., Helv. Odont. Acta 11: 131, 1967.Google Scholar
  5. 5.
    de Stoppelaar, J. D., König, K. G., Plasschaert, A.J.M. and v.d. Hoeven, J. S., Arch. Oral Biol. 16: 971, 1971.PubMedCrossRefGoogle Scholar
  6. 6.
    Gibbons, R. J., Caries Res. 2: 164, 1968.PubMedCrossRefGoogle Scholar
  7. 7.
    Gibbons, R. J. and Fitzgerald, R. J., J. Bacteriol. 98: 341, 1969.PubMedGoogle Scholar
  8. 8.
    Rölla, G. and Kilian, M., Caries Res. 11: 85, 1977.PubMedCrossRefGoogle Scholar
  9. 9.
    Kilian, M. and Rölla, G., Infect. Immun. 14: 1022, 1976.PubMedGoogle Scholar
  10. 10.
    Krasse, B., Edwardsson, S., Svensson, J. and Trell, L., Arch. Oral Biol. 12: 231, 1967.PubMedCrossRefGoogle Scholar
  11. 11.
    Sidebotham, R. L., Weigel, H. and Bowen, W. H., Carbohyd. Res. 19: 151, 1971.CrossRefGoogle Scholar
  12. 12.
    Rölla, G. and Mathisen, B., in Dental Plaque (Edited by McHugh, W. D.) p. 129, E. & S. Livingstone, Edinburg, 1970.Google Scholar
  13. 13.
    Melvaer, K. L., Helgeland, K. and Rölla, G., Arch. Oral Biol. 19: 539, 1974.CrossRefGoogle Scholar
  14. 14.
    Markham, J. L., Knox, K. W., Wicken, A. J. and Hewett, M. J., Infect. Immun. 12: 378, 1975.PubMedGoogle Scholar
  15. 15.
    Rölla, G., Caries Res. 22: Suppl. 1 243, 1977.CrossRefGoogle Scholar
  16. 16.
    Rölla, G., in Microbial Aspects of Dental Caries (Edited by Stiles, H. M., Loesche, W. J. and O’Brien, T. C.) Vol. 2, p. 309, Information Retrieval, Arlington, 1976.Google Scholar
  17. 17.
    Ciardi, J. E., Rölla, G., Bowen, W. H. and Reilly, J. A., Scand. J. Dent. Res. 85: in press, 1977.Google Scholar
  18. 18.
    Termine, J. and Conn, K. M., Cale. Tiss. Res. 22: 149, 1976.Google Scholar
  19. 19.
    Beech, D. R., Arch. Oral Biol. 17: 907, 1972.PubMedCrossRefGoogle Scholar
  20. 20.
    Bernardi, G., Giro, M. G. and Giallard, C., Biochim. Biophys. Acta 278: 409, 1972.PubMedGoogle Scholar
  21. 21.
    Joseph, R. and Shockman, G. D., Infect. Immun. 12: 333, 1975.PubMedGoogle Scholar
  22. 22.
    Shockman, G. D., Tsien, H. C., Kessler, R. F., Mychajlonka, M., Higgins, M. L. and Daneo-Moore, L., in Microbial Aspects of Dental Caries (Edited by Stiles, H. M., Loesche, W. J. and O’Brien, T. C.) Vol. 3, p. 631, Information Retrieval, Arlington, 1976.Google Scholar
  23. 23.
    Iversen, O. J., Rölla, G. and Bonesvoll, P., Caries Res. Abstr. ORCA Congress 1977, Megeve, France, in press, 1977.Google Scholar
  24. 24.
    Rölla, G., Robrish, S. and Bowen, W. H., Acta Path. Microbiol. Scand. in press, 1977.Google Scholar
  25. 25.
    Skjörland, K., Gjermo, P. and Rölla, G., Scand. J. Dent. Res. in press, 1978.Google Scholar
  26. 26.
    Rölla, G. and Meisen, B., J. Dent. Res. 54B: B57, 1975.Google Scholar
  27. 27.
    Mukasa, H. and Slade, H. D.,. Infect. Immun. 8: 555, 1973.PubMedGoogle Scholar
  28. 28.
    Gibbons, R. G. and Quereshi, J. V., in Microbial Aspects of Dental Caries (Edited by Stiles, H. M., Loesche, W. J. and O’Brien, T. C.), Vol. 1, p. 163, Information Retrieval, Arlington, 1976.Google Scholar
  29. 29.
    Rappaport, C., in The Chemistry of Biosurfaces (Edited by Hair, M. L.), Vol. 2, p. 449, M. Dekker, Inc., New York, 1971.Google Scholar
  30. 30.
    Norde, W., Proteins at Interfaces, Thesis, p. 87, Agricultural University, Wageningen, 1976.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • G. Rölla
    • 1
    • 2
  • O.-J. Iversen
    • 2
  • P. Bonesvoll
    • 2
  1. 1.Departments of Pedodontics and Caries ProphylaxisUSA
  2. 2.Physiology and Biochemistry, Dental FacultyUniversity of OsloOsloNorway

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