I think there is a possibility that the appearance of plasma cells in sites, such as submandibular gland, represents dissemination of plasma cell-precursors of enteric origin. But, I think it is important to recognize that these animals have clear evidence of prior experience with the antigens and it is not difficult to imagine that the submandibular gland in a pig is well exposed to enteric antigens. If antigen has anything to do with the homing of specific precursor cells, it is entirely possible that antigen has previously been trapped at many other mucosal sites. The demonstration of a response in a distant site, such as the submandibular gland, may well be due to the homing that, in this situation, has occurred under antigenic stimulus; it should not necessarily be confused with the homing that is not dependent on antigenic stimulus. They may represent two very different mechanisms of homing.
KeywordsSubmandibular Gland Secondary Response Mucosal Site Antigenic Stimulus Sodium Thiocyanate
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