Immunoglobulin A in Secretions from the Lower Human Respiratory Tract

  • Herbert Y. Reynolds
  • William M. Merrill
  • Edward P. Amento
  • Gary P. Naegel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)


Although the focus of this Symposium is on the function of secretory immunoglobulin A (s-IgA) in the oropharynx, the domain of this fascinating, but still engimatic, immunoglobulin molecule is widespread. It is present in mucosal secretions from mucosal surfaces of the respiratory tract and the gastrointestine and it is contained in excretory fluids of the genitourinary system, lacrimal glands, breasts and the middle ear (1,2). This paper will address the role of s-IgA in the lower respiratory tract of humans through a discussion of: 1) its relative concentration in secretions obtained from the airways, 2) its molecular characteristics and 3) its function (or lack of one) in the broncho-alveolar milieu.


Alveolar Macrophage Lower Respiratory Tract Sucrose Density Gradient Bronchial Secretion Respiratory Secretion 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Herbert Y. Reynolds
    • 1
  • William M. Merrill
    • 1
  • Edward P. Amento
    • 1
  • Gary P. Naegel
    • 1
  1. 1.Pulmonary Section, Department of Internal MedicineYale University School of MedicineNew HavenUSA

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