Advertisement

Immunoglobulin A in Secretions from the Lower Human Respiratory Tract

  • Herbert Y. Reynolds
  • William M. Merrill
  • Edward P. Amento
  • Gary P. Naegel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)

Abstract

Although the focus of this Symposium is on the function of secretory immunoglobulin A (s-IgA) in the oropharynx, the domain of this fascinating, but still engimatic, immunoglobulin molecule is widespread. It is present in mucosal secretions from mucosal surfaces of the respiratory tract and the gastrointestine and it is contained in excretory fluids of the genitourinary system, lacrimal glands, breasts and the middle ear (1,2). This paper will address the role of s-IgA in the lower respiratory tract of humans through a discussion of: 1) its relative concentration in secretions obtained from the airways, 2) its molecular characteristics and 3) its function (or lack of one) in the broncho-alveolar milieu.

Keywords

Alveolar Macrophage Lower Respiratory Tract Sucrose Density Gradient Bronchial Secretion Respiratory Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Tomasi, T. B., Jr., N. Eng. J. Med. 287: 500, 1972.Google Scholar
  2. 2.
    Lamm, M. E., Adv. Immun. 22: 223, 1976.PubMedCrossRefGoogle Scholar
  3. 3.
    Reynolds, H.Y. and Newbalî7 H. H., J. Lab. Clin. Med. 84: 559, 1974.PubMedGoogle Scholar
  4. 4.
    Reynolds, H. Y., Atkinson, J. P., Newball, H. H. and Frank, M. M., J. Immunol. 114: 1813, 1975.PubMedGoogle Scholar
  5. 5.
    Reynolds, H. Y. and Newball, H. H., in Immunologic and Infectious Reactions in the Lung (Edited by Kirkpatrick, C. H. and Reynolds, H. Y.) p. 3, Marcel Dekker, Inc., New York, 1976.Google Scholar
  6. 6.
    Credle, W. R., Jr., Smiddy, J. F. and Elliott, R. C., Am. Rev. Respir. Dis. 109: 67, 1974.Google Scholar
  7. 7.
    Pereira, W., Kovnat, D. M., Khan, M. A., Iacovino, J. L., Apivack, M. L. and Snider, G. L., Amer. Rev. Resp. Dis. 112: 59, 1975.PubMedGoogle Scholar
  8. 8.
    Ouchterlony, O., Progr. Allergy 5: 1, 1958.Google Scholar
  9. 9.
    Reynolds, H. Y., Levine, A. S., Wood, R. E., Zierdt, C. H., Dale, D. C. and Pennington, J. E., Ann. Int. Med. 82: 819, 1975.Google Scholar
  10. 10.
    Reynolds, H. Y., Kazmierowski, J. A. and Newball, H. H., J. Clin. Invest. 56: 376, 1975.PubMedCrossRefGoogle Scholar
  11. 11.
    Strober, W., Krakauer, R., Kleaveman, H. L., Reynolds, H. Y. and Nelson, D. L., N. Eng. J. Med. 294: 351, 1976.CrossRefGoogle Scholar
  12. 12.
    Thompson, R. E., Reynolds, H. Y. and Waxdal, M. J., Biochemistry 14: 2853, 1975.PubMedCrossRefGoogle Scholar
  13. 13.
    Goodenheger, D., Merrill, W., Naegel, G. P., Strober, W. and Reynolds, H. Y., preliminary observation.Google Scholar
  14. 14.
    Reynolds, H. Y. and Thompson, R. E., J. Immunol. 111: 369, 1973.PubMedGoogle Scholar
  15. 15.
    Robertson, J., Caldwell, J. R., Castle, J. R. and Waldman, R. H., J. Immunol. 117: 900, 1976.PubMedGoogle Scholar
  16. 16.
    Reynolds, H. Y., McPhedran, P., Matthay, R. A. and Naegel, G. P., preliminary observation.Google Scholar
  17. 17.
    Vaerman, J. P. and Heremans, J. F., Immunology 18: 27, 1970.PubMedGoogle Scholar
  18. 18.
    Reynolds, H. Y. and Johnson, J. S., Biochemistry 10: 2821, 1971.PubMedCrossRefGoogle Scholar
  19. 19.
    Rossen, R. D., Alford, R. H., Butler, W. T. and Vannier, W. E., J. Immunol. 97: 369, 1966.PubMedGoogle Scholar
  20. 20.
    Tomasi, T. B., Jr., Tan, E. M., Solomon, A. and Prendergast, R. A., J. Exp. Med. 121: 101, 1965.PubMedCrossRefGoogle Scholar
  21. 21.
    Reynolds, H. Y., Fulmer, J. K., Kazmierowski, J. A., Roberts, W. C., Frank, M. M. and Crystal, R. G., J. Clin. Invest. 59: 165, 1977.PubMedCrossRefGoogle Scholar
  22. 22.
    Reynolds, H. Y. and Thompson, R. E., J. Immunol. 111: 358, 1973.PubMedGoogle Scholar
  23. 23.
    Pennington, J. E. and Reynolds, H. Y., J. Infect. Dis. 128: 63, 1973.PubMedCrossRefGoogle Scholar
  24. 24.
    Kaltreider, H. B. and Chan, M.K.L., J. Immunol. 116: 423, 1976.PubMedGoogle Scholar
  25. 25.
    Golde, D. W., Einley, T. N., Cline, M. J., N. Eng. J. Med. 290: 875, 1974.Google Scholar
  26. 26.
    Adinolfi, M., Glynn, A. A., Lindsay, M. and Milne, C. M., Immunology 10: 517, 1966.PubMedGoogle Scholar
  27. 27.
    Kaplan, M. E., Dalmasso, A. P. and Woodson, M., J. Immunol. 108: 275, 1972.PubMedGoogle Scholar
  28. 28.
    Eddie, D. S., Schulkind, M. L. and Robbins, J. B., J. Immunol. 106: 181, 1971.PubMedGoogle Scholar
  29. 29.
    Wilson, I. D., J. Immunol. 108: 726, 1972.PubMedGoogle Scholar
  30. 30.
    Zipursky, A., Brown, E. J. and Bienenstock, J., Proc. Soc. Exp. Biol. Med. 142: 181, 1973.PubMedGoogle Scholar
  31. 31.
    Kazmierowski, J. A., Aduan, R. P. and Reynolds, H. Y., Eur. J. Resp. Pathophys. 13: 103, 1977.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Herbert Y. Reynolds
    • 1
  • William M. Merrill
    • 1
  • Edward P. Amento
    • 1
  • Gary P. Naegel
    • 1
  1. 1.Pulmonary Section, Department of Internal MedicineYale University School of MedicineNew HavenUSA

Personalised recommendations