Effect on Rat IgA Synthesis by Isotypic Suppression with an Anti-Rat Delta Heavy Chain Serum
Studies by Kincade et al. (1) in chickens and by Manning and Jutila (2) and Lawton et al. (3) in mice have shown that neonatal injection of anti-u heavy chain can significantly suppress the synthesis of not only IgM but also IgA and IgG classes. Moreover, in both these species, IgM molecules seem to be the first to appear on the cell membranes during the development of the embryos (4–6). In consequence, it is reasonable to believe that all IgG and IgA synthetizing cells derive from IgM bearing cells. Recently, Manning et al. (7) extended these results to the formation of the reaginic antibodies of the IgE class.
KeywordsMesenteric Lymph Node Normal Rabbit Serum Bearing Cell Mesenteric Lymph Node Cell Reaginic Antibody
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